A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls
Our aim was to observe the induction of anxiety symptoms and panic attacks by a caffeine challenge test in panic disorder (PD) patients (DSM‐IV) and their healthy first‐degree relatives. We randomly selected 25 PD patients, 27 healthy first‐degree relatives of probands with PD, and 22 healthy volunt...
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| Veröffentlicht in: | Depression and anxiety 2008-10, Vol.25 (10), p.847-853 |
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| creator | Nardi, Antonio E. Valença, Alexandre M. Nascimento, Isabella Freire, Rafael C. Veras, André B. de-Melo-Neto, Valfrido L. Lopes, Fabiana L. King, Anna Lucia Soares-Filho, Gastão L. Mezzasalma, Marco A. Rassi, Arabella Zin, Walter A. |
| description | Our aim was to observe the induction of anxiety symptoms and panic attacks by a caffeine challenge test in panic disorder (PD) patients (DSM‐IV) and their healthy first‐degree relatives. We randomly selected 25 PD patients, 27 healthy first‐degree relatives of probands with PD, and 22 healthy volunteers with no family history of PD. In a randomized double‐blind experiment performed over two occasions 7 days apart, 480 mg caffeine and a caffeine‐free solution were administered in a coffee form. Using specific panic attack criteria, 52.0% (n=13) PD patients, 40.7% (n=11) first‐degree relatives (χ2=1.81, df=1, P=0.179), and none of the control subjects had a panic attack after the test (χ2=51.7, df=2, P |
| doi_str_mv | 10.1002/da.20354 |
| format | Article |
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We randomly selected 25 PD patients, 27 healthy first‐degree relatives of probands with PD, and 22 healthy volunteers with no family history of PD. In a randomized double‐blind experiment performed over two occasions 7 days apart, 480 mg caffeine and a caffeine‐free solution were administered in a coffee form. Using specific panic attack criteria, 52.0% (n=13) PD patients, 40.7% (n=11) first‐degree relatives (χ2=1.81, df=1, P=0.179), and none of the control subjects had a panic attack after the test (χ2=51.7, df=2, P<0.001). In this caffeine challenge test, PD patients and their first‐degree relatives were more sensitive than healthy volunteers to the panic attack symptoms but less sensitive to headache, increase in blood pressure, and insomnia. Our data suggest that there is an association between panic attacks after the intake of 480 mg of caffeine in PD patients and their first‐degree relatives. There is a clear differentiation of PD patients and their first‐degree relatives by a caffeine test from the healthy group. Depression and Anxiety, 2008. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 1091-4269</identifier><identifier>EISSN: 1520-6394</identifier><identifier>DOI: 10.1002/da.20354</identifier><identifier>PMID: 17823963</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; anxiety disorder ; Arousal - drug effects ; Arousal - genetics ; Caffeine ; Central Nervous System Stimulants ; Citrates ; coffee ; comorbidity ; Double-Blind Method ; Female ; Genetic Predisposition to Disease - genetics ; Genetic Predisposition to Disease - psychology ; Humans ; Male ; Middle Aged ; panic attacks ; Panic Disorder - diagnosis ; Panic Disorder - genetics ; Panic Disorder - psychology ; Personality Inventory ; Phenotype ; stimulant drug ; Young Adult</subject><ispartof>Depression and anxiety, 2008-10, Vol.25 (10), p.847-853</ispartof><rights>2007 Wiley‐Liss, Inc.</rights><rights>Depression and Anxiety, 2008. (c) 2007 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4534-634ed2173b1e7ff8cf97b7afbbe1388f81cda80058e9a87f07ebd3ab8c29837b3</citedby><cites>FETCH-LOGICAL-c4534-634ed2173b1e7ff8cf97b7afbbe1388f81cda80058e9a87f07ebd3ab8c29837b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fda.20354$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fda.20354$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17823963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nardi, Antonio E.</creatorcontrib><creatorcontrib>Valença, Alexandre M.</creatorcontrib><creatorcontrib>Nascimento, Isabella</creatorcontrib><creatorcontrib>Freire, Rafael C.</creatorcontrib><creatorcontrib>Veras, André B.</creatorcontrib><creatorcontrib>de-Melo-Neto, Valfrido L.</creatorcontrib><creatorcontrib>Lopes, Fabiana L.</creatorcontrib><creatorcontrib>King, Anna Lucia</creatorcontrib><creatorcontrib>Soares-Filho, Gastão L.</creatorcontrib><creatorcontrib>Mezzasalma, Marco A.</creatorcontrib><creatorcontrib>Rassi, Arabella</creatorcontrib><creatorcontrib>Zin, Walter A.</creatorcontrib><title>A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls</title><title>Depression and anxiety</title><addtitle>Depress. Anxiety</addtitle><description>Our aim was to observe the induction of anxiety symptoms and panic attacks by a caffeine challenge test in panic disorder (PD) patients (DSM‐IV) and their healthy first‐degree relatives. We randomly selected 25 PD patients, 27 healthy first‐degree relatives of probands with PD, and 22 healthy volunteers with no family history of PD. In a randomized double‐blind experiment performed over two occasions 7 days apart, 480 mg caffeine and a caffeine‐free solution were administered in a coffee form. Using specific panic attack criteria, 52.0% (n=13) PD patients, 40.7% (n=11) first‐degree relatives (χ2=1.81, df=1, P=0.179), and none of the control subjects had a panic attack after the test (χ2=51.7, df=2, P<0.001). In this caffeine challenge test, PD patients and their first‐degree relatives were more sensitive than healthy volunteers to the panic attack symptoms but less sensitive to headache, increase in blood pressure, and insomnia. Our data suggest that there is an association between panic attacks after the intake of 480 mg of caffeine in PD patients and their first‐degree relatives. There is a clear differentiation of PD patients and their first‐degree relatives by a caffeine test from the healthy group. Depression and Anxiety, 2008. © 2007 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>anxiety disorder</subject><subject>Arousal - drug effects</subject><subject>Arousal - genetics</subject><subject>Caffeine</subject><subject>Central Nervous System Stimulants</subject><subject>Citrates</subject><subject>coffee</subject><subject>comorbidity</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic Predisposition to Disease - psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>panic attacks</subject><subject>Panic Disorder - diagnosis</subject><subject>Panic Disorder - genetics</subject><subject>Panic Disorder - psychology</subject><subject>Personality Inventory</subject><subject>Phenotype</subject><subject>stimulant drug</subject><subject>Young Adult</subject><issn>1091-4269</issn><issn>1520-6394</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctOGzEUBmCrApVLK_UJKq8QC4b6MjO2l1G4FUG7adWl5bGPiYszE2yHNm_P0KSwQrA650iffunoR-gTJceUEPbFmWNGeFO_Q7u0YaRquaq3xp0oWtWsVTtoL-ffhBCpJHmPdqiQjKuW76LFBFvjPYQesJ2ZGKG_AVwgFxx6vDB9sNiFPCQHaTxLgL7kI1xmEBKegYlltsI-pFwqBzcJACeII7uHUZnePRk79CUNMX9A297EDB83cx_9PDv9Mb2orr6ff51OripbN7weP6jBMSp4R0F4L61XohPGdx1QLqWX1DojCWkkKCOFJwI6x00nLVOSi47vo4N17iINd8vxHz0P2UKMpodhmXWr2oYoKV6FjDKqasHfAImUkj_CwzW0acg5gdeLFOYmrTQl-rEv7Yz-19dIP28yl90c3DPcFDSCag3-hAirF4P0yeR_4MaHXODvkzfpVreCi0b_-nauz07YJW2vp7rhD3c-reY</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Nardi, Antonio E.</creator><creator>Valença, Alexandre M.</creator><creator>Nascimento, Isabella</creator><creator>Freire, Rafael C.</creator><creator>Veras, André B.</creator><creator>de-Melo-Neto, Valfrido L.</creator><creator>Lopes, Fabiana L.</creator><creator>King, Anna Lucia</creator><creator>Soares-Filho, Gastão L.</creator><creator>Mezzasalma, Marco A.</creator><creator>Rassi, Arabella</creator><creator>Zin, Walter A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls</title><author>Nardi, Antonio E. ; Valença, Alexandre M. ; Nascimento, Isabella ; Freire, Rafael C. ; Veras, André B. ; de-Melo-Neto, Valfrido L. ; Lopes, Fabiana L. ; King, Anna Lucia ; Soares-Filho, Gastão L. ; Mezzasalma, Marco A. ; Rassi, Arabella ; Zin, Walter A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4534-634ed2173b1e7ff8cf97b7afbbe1388f81cda80058e9a87f07ebd3ab8c29837b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>anxiety disorder</topic><topic>Arousal - drug effects</topic><topic>Arousal - genetics</topic><topic>Caffeine</topic><topic>Central Nervous System Stimulants</topic><topic>Citrates</topic><topic>coffee</topic><topic>comorbidity</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetic Predisposition to Disease - psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>panic attacks</topic><topic>Panic Disorder - diagnosis</topic><topic>Panic Disorder - genetics</topic><topic>Panic Disorder - psychology</topic><topic>Personality Inventory</topic><topic>Phenotype</topic><topic>stimulant drug</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nardi, Antonio E.</creatorcontrib><creatorcontrib>Valença, Alexandre M.</creatorcontrib><creatorcontrib>Nascimento, Isabella</creatorcontrib><creatorcontrib>Freire, Rafael C.</creatorcontrib><creatorcontrib>Veras, André B.</creatorcontrib><creatorcontrib>de-Melo-Neto, Valfrido L.</creatorcontrib><creatorcontrib>Lopes, Fabiana L.</creatorcontrib><creatorcontrib>King, Anna Lucia</creatorcontrib><creatorcontrib>Soares-Filho, Gastão L.</creatorcontrib><creatorcontrib>Mezzasalma, Marco A.</creatorcontrib><creatorcontrib>Rassi, Arabella</creatorcontrib><creatorcontrib>Zin, Walter A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Depression and anxiety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nardi, Antonio E.</au><au>Valença, Alexandre M.</au><au>Nascimento, Isabella</au><au>Freire, Rafael C.</au><au>Veras, André B.</au><au>de-Melo-Neto, Valfrido L.</au><au>Lopes, Fabiana L.</au><au>King, Anna Lucia</au><au>Soares-Filho, Gastão L.</au><au>Mezzasalma, Marco A.</au><au>Rassi, Arabella</au><au>Zin, Walter A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls</atitle><jtitle>Depression and anxiety</jtitle><addtitle>Depress. Anxiety</addtitle><date>2008-10</date><risdate>2008</risdate><volume>25</volume><issue>10</issue><spage>847</spage><epage>853</epage><pages>847-853</pages><issn>1091-4269</issn><eissn>1520-6394</eissn><abstract>Our aim was to observe the induction of anxiety symptoms and panic attacks by a caffeine challenge test in panic disorder (PD) patients (DSM‐IV) and their healthy first‐degree relatives. We randomly selected 25 PD patients, 27 healthy first‐degree relatives of probands with PD, and 22 healthy volunteers with no family history of PD. In a randomized double‐blind experiment performed over two occasions 7 days apart, 480 mg caffeine and a caffeine‐free solution were administered in a coffee form. Using specific panic attack criteria, 52.0% (n=13) PD patients, 40.7% (n=11) first‐degree relatives (χ2=1.81, df=1, P=0.179), and none of the control subjects had a panic attack after the test (χ2=51.7, df=2, P<0.001). In this caffeine challenge test, PD patients and their first‐degree relatives were more sensitive than healthy volunteers to the panic attack symptoms but less sensitive to headache, increase in blood pressure, and insomnia. Our data suggest that there is an association between panic attacks after the intake of 480 mg of caffeine in PD patients and their first‐degree relatives. There is a clear differentiation of PD patients and their first‐degree relatives by a caffeine test from the healthy group. Depression and Anxiety, 2008. © 2007 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17823963</pmid><doi>10.1002/da.20354</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Depression and anxiety, 2008-10, Vol.25 (10), p.847-853 |
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| subjects | Adult anxiety disorder Arousal - drug effects Arousal - genetics Caffeine Central Nervous System Stimulants Citrates coffee comorbidity Double-Blind Method Female Genetic Predisposition to Disease - genetics Genetic Predisposition to Disease - psychology Humans Male Middle Aged panic attacks Panic Disorder - diagnosis Panic Disorder - genetics Panic Disorder - psychology Personality Inventory Phenotype stimulant drug Young Adult |
| title | A caffeine challenge test in panic disorder patients, their healthy first-degree relatives, and healthy controls |
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