Ghrelin signalling in guinea-pig femoral artery smooth muscle cells

Our aim was to study the new signalling pathway of ghrelin in the guinea-pig femoral artery using the outward IK as a sensor. Whole-cell patch-clamp experiments were performed on single smooth muscle cells, freshly isolated from the guinea-pig femoral artery. The contractile force of isometric prepa...

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Veröffentlicht in:	Acta Physiologica 2008-11, Vol.194 (3), p.195-206
Hauptverfasser:	Mladenov, M.I, Hristov, K.L, Dimitriova, D.Z, Schubert, R, Lubomirov, L.T, Gjorgoski, I.K, Duridanova, D.B, Gagov, H.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences depolarization Dose-Response Relationship, Drug Endothelin-1 - pharmacology Femoral Artery - drug effects Femoral Artery - metabolism Femoral Artery - physiology Fundamental and applied biological sciences. Psychology ghrelin Ghrelin - pharmacology GPCR Guinea Pigs hormone Intermediate-Conductance Calcium-Activated Potassium Channels - drug effects Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism Male Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - physiology patch clamp Patch-Clamp Techniques Peptides - pharmacology Phosphoinositide Phospholipase C - physiology Protein Kinase C - physiology second messengers Signal Transduction - drug effects Signal Transduction - physiology Type C Phospholipases - physiology Vasoconstriction - drug effects Vasoconstriction - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems
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