Recruitment of pleckstrin and phosphoinositide 3-kinase gamma into the cell membranes, and their association with G beta gamma after activation of NK cells with chemokines

The role of phosphoinositide 3 kinases (PI 3-K) in chemokine-induced NK cell chemotaxis was investigated. Pretreatment of NK cells with wortmannin inhibits the in vitro chemotaxis of NK cells induced by lymphotactin, monocyte-chemoattractant protein-1, RANTES, IFN-inducible protein-10, or stromal-de...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-03, Vol.162 (6), p.3249-3255
Hauptverfasser:	al-Aoukaty, A, Rolstad, B, Maghazachi, A A
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Biological Transport - drug effects Biological Transport - immunology Blood Platelets - metabolism Blood Proteins - metabolism Cell Membrane - drug effects Cell Membrane - enzymology Cell Membrane - metabolism Chemokine CCL5 - pharmacology Chemokines - pharmacology Chemotaxis, Leukocyte - immunology Dimerization Drug Resistance GTP-Binding Proteins - immunology GTP-Binding Proteins - metabolism Humans Killer Cells, Natural - drug effects Killer Cells, Natural - enzymology Killer Cells, Natural - immunology Lymphocyte Activation - immunology Macromolecular Substances Pertussis Toxin Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol 3-Kinases - physiology Phosphoproteins Virulence Factors, Bordetella - pharmacology
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