Effects of diabetes and treatment with the antioxidant α-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats

Diabetes mellitus is associated with impotence in animal models and patients. Raised reactive oxygen species contribute to diabetic neurovascular deficits, which are amenable to antioxidant treatment. Our aim was to examine the effects of streptozotocin-induced diabetes in rats and long-term treatme...

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Veröffentlicht in:	Diabetologia 1999-03, Vol.42 (3), p.343-350
Hauptverfasser:	KEEGAN, A, COTTER, M. A, CAMERON, N. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Antioxidants - pharmacology Atropine - pharmacology Biological and medical sciences Blood Glucose - drug effects Blood Glucose - metabolism Body Weight - drug effects Diabetes Mellitus, Experimental - physiopathology Diabetic Neuropathies - physiopathology Electric Stimulation Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology General and cellular metabolism. Vitamins In Vitro Techniques Male Medical sciences Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - innervation Muscle, Smooth - physiopathology Nitric Oxide - pharmacology Nitric Oxide - physiology Penis - drug effects Penis - innervation Penis - physiopathology Pharmacology. Drug treatments Phenylephrine - pharmacology Rats Rats, Sprague-Dawley Thioctic Acid - pharmacology
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