Transcriptional activity and regulatory protein binding of metal‐responsive elements of the human metallothionein‐IIA gene

Multiple copies of a cis‐acting DNA element, metal‐responsive element (MRE) are required for heavy metal‐induced transcriptional activation of mammalian metallothionein genes. To approach the regulatory mechanism mediated by these multiple elements, we studied the properties of seven MREs located up...

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Veröffentlicht in:	European journal of biochemistry 1999-02, Vol.259 (3), p.635-642
Hauptverfasser:	Koizumi, Shinji, Suzuki, Kaoru, Ogra, Yasumitsu, Yamada, Hirotomo, Otsuka, Fuminori
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA-Binding Proteins - genetics Gene Expression Regulation - genetics Genes, Reporter - genetics heavy metals HeLa Cells Humans metallothionein Metallothionein - genetics metallothionein IIA Metals - metabolism MT-IIA gene Mutation - genetics Oligodeoxyribonucleotides - genetics Oligodeoxyribonucleotides - metabolism Promoter Regions, Genetic - genetics protein–nucleic acid interaction Regulatory Sequences, Nucleic Acid - genetics transcription factor Transcription Factor MTF-1 Transcription Factors - genetics Transcription, Genetic - genetics Transfection - genetics zinc Zinc - metabolism
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