Regulatory Effects of Endogenous Protease Inhibitors in Acute Lung Inflammatory Injury

Inflammatory lung injury is probably regulated by the balance between proteases and protease inhibitors together with oxidants and antioxidants, and proinflammatory and anti-inflammatory cytokines. Rat tissue inhibitor of metalloprotease-2 (TIMP-2) and secreted leukoprotease inhibitor (SLPI) were cl...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-03, Vol.162 (6), p.3653-3662
Hauptverfasser:	Gipson, Teletha S, Bless, Nicolas M, Shanley, Thomas P, Crouch, Larry D, Bleavins, Michael R, Younkin, Ellen M, Sarma, Vidya, Gibbs, Douglas F, Tefera, Wongelawit, McConnell, Patrick C, Mueller, William T, Johnson, Kent J, Ward, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Alveolitis, Extrinsic Allergic - enzymology Alveolitis, Extrinsic Allergic - immunology Alveolitis, Extrinsic Allergic - pathology Amino Acid Sequence Animals Antigen-Antibody Complex - administration & dosage Base Sequence Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - immunology Chemokines - analysis Chemotaxis, Leukocyte - immunology Cloning, Molecular Complement C5a - analysis Immune Sera - administration & dosage Immunoglobulin G - administration & dosage Lung - enzymology Lung - immunology Lung - pathology Male Metalloendopeptidases - metabolism Molecular Sequence Data Protein Biosynthesis Proteinase Inhibitory Proteins, Secretory Proteins - genetics Proteins - immunology Proteins - physiology Rats Rats, Long-Evans RNA, Messenger - biosynthesis Secretory Leukocyte Peptidase Inhibitor Serine Proteinase Inhibitors - genetics Serine Proteinase Inhibitors - physiology Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-2 - immunology Tissue Inhibitor of Metalloproteinase-2 - physiology Tumor Necrosis Factor-alpha - analysis
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