Endothelial cell growth factor enhances musculocutaneous flap survival through the process of neovascularization
The effect of an angiogenic growth factor-endothelial cell growth factor (ECGF)-was tested in the rat transverse rectus abdominis musculocutaneous (TRAM) flap model based on a single inferior vascular pedicle. The animals were divided into three groups (N = 8 per group) after flap elevation. In grou...
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| Veröffentlicht in: | Annals of plastic surgery 1999-03, Vol.42 (3), p.306-312 |
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| container_title | Annals of plastic surgery |
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| creator | PU, L. L. Q AHMED, S THOMSON, J. G REID, M. A MADSEN, J. A RESTIFO, R. J |
| description | The effect of an angiogenic growth factor-endothelial cell growth factor (ECGF)-was tested in the rat transverse rectus abdominis musculocutaneous (TRAM) flap model based on a single inferior vascular pedicle. The animals were divided into three groups (N = 8 per group) after flap elevation. In group A (control), each animal received both local and local intra-arterial injections of 1 ml saline. In group B (local), each received a 2-mg ECGF local injection and 1-ml saline local intra-arterial injection. In group C (local intra-arterial), each received a 1-ml saline local injection and a 2-mg ECGF local intra-arterial injection. All animals were evaluated on postoperative day 7. There was a significant increase in the percentage of the skin paddle survival area of the TRAM flap in both ECGF-treated groups when compared with the control group (group B vs. group A, p < 0.001; group C vs. group A, p < 0.001). This correlated with a significant increase in vascularity in both ECGF-treated groups compared with the control group (group B vs. group A, p = 0.007; group C vs. group A, p = 0.021). The results between groups B and C were not significant. ECGF, when administered via either local or local intra-arterial route, enhances musculocutaneous flap survival through the process of neovascularization. |
| doi_str_mv | 10.1097/00000637-199903000-00013 |
| format | Article |
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L. Q ; AHMED, S ; THOMSON, J. G ; REID, M. A ; MADSEN, J. A ; RESTIFO, R. J</creator><creatorcontrib>PU, L. L. Q ; AHMED, S ; THOMSON, J. G ; REID, M. A ; MADSEN, J. A ; RESTIFO, R. J</creatorcontrib><description>The effect of an angiogenic growth factor-endothelial cell growth factor (ECGF)-was tested in the rat transverse rectus abdominis musculocutaneous (TRAM) flap model based on a single inferior vascular pedicle. The animals were divided into three groups (N = 8 per group) after flap elevation. In group A (control), each animal received both local and local intra-arterial injections of 1 ml saline. In group B (local), each received a 2-mg ECGF local injection and 1-ml saline local intra-arterial injection. In group C (local intra-arterial), each received a 1-ml saline local injection and a 2-mg ECGF local intra-arterial injection. All animals were evaluated on postoperative day 7. There was a significant increase in the percentage of the skin paddle survival area of the TRAM flap in both ECGF-treated groups when compared with the control group (group B vs. group A, p < 0.001; group C vs. group A, p < 0.001). This correlated with a significant increase in vascularity in both ECGF-treated groups compared with the control group (group B vs. group A, p = 0.007; group C vs. group A, p = 0.021). The results between groups B and C were not significant. ECGF, when administered via either local or local intra-arterial route, enhances musculocutaneous flap survival through the process of neovascularization.</description><identifier>ISSN: 0148-7043</identifier><identifier>EISSN: 1536-3708</identifier><identifier>DOI: 10.1097/00000637-199903000-00013</identifier><identifier>PMID: 10096623</identifier><identifier>CODEN: APCSD4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Endothelial Growth Factors - administration & dosage ; Endothelial Growth Factors - pharmacology ; Male ; Medical sciences ; Miscellaneous ; Muscle ; Neovascularization, Physiologic - drug effects ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Rectus Abdominis - blood supply ; Rectus Abdominis - drug effects ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical Flaps - blood supply ; Tissue Survival - drug effects</subject><ispartof>Annals of plastic surgery, 1999-03, Vol.42 (3), p.306-312</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-7cad1d29062ec29c88b0b0f861d2ed82153b7c5708f5d89d559f4f5d2ee523503</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1711949$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10096623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PU, L. L. Q</creatorcontrib><creatorcontrib>AHMED, S</creatorcontrib><creatorcontrib>THOMSON, J. G</creatorcontrib><creatorcontrib>REID, M. A</creatorcontrib><creatorcontrib>MADSEN, J. A</creatorcontrib><creatorcontrib>RESTIFO, R. J</creatorcontrib><title>Endothelial cell growth factor enhances musculocutaneous flap survival through the process of neovascularization</title><title>Annals of plastic surgery</title><addtitle>Ann Plast Surg</addtitle><description>The effect of an angiogenic growth factor-endothelial cell growth factor (ECGF)-was tested in the rat transverse rectus abdominis musculocutaneous (TRAM) flap model based on a single inferior vascular pedicle. The animals were divided into three groups (N = 8 per group) after flap elevation. In group A (control), each animal received both local and local intra-arterial injections of 1 ml saline. In group B (local), each received a 2-mg ECGF local injection and 1-ml saline local intra-arterial injection. In group C (local intra-arterial), each received a 1-ml saline local injection and a 2-mg ECGF local intra-arterial injection. All animals were evaluated on postoperative day 7. There was a significant increase in the percentage of the skin paddle survival area of the TRAM flap in both ECGF-treated groups when compared with the control group (group B vs. group A, p < 0.001; group C vs. group A, p < 0.001). This correlated with a significant increase in vascularity in both ECGF-treated groups compared with the control group (group B vs. group A, p = 0.007; group C vs. group A, p = 0.021). The results between groups B and C were not significant. ECGF, when administered via either local or local intra-arterial route, enhances musculocutaneous flap survival through the process of neovascularization.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Endothelial Growth Factors - administration & dosage</subject><subject>Endothelial Growth Factors - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Muscle</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rectus Abdominis - blood supply</subject><subject>Rectus Abdominis - drug effects</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical Flaps - blood supply</subject><subject>Tissue Survival - drug effects</subject><issn>0148-7043</issn><issn>1536-3708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkElLxDAYhoMozjj6FyQH8VbN0mY5yuAGA170XNI0mVbapibtiP56UzsugZCF502-7wEAYnSFkeTXaBqM8gRLKRGNhyROTA_AEmeUJZQjcQiWCKci4SilC3ASwmskiEjZMVhghCRjhC5Bf9uVbqhMU6sGatM0cOvd-1BBq_TgPDRdpTptAmzHoMfG6XFQnXFjgLZRPQyj39W7GB0q78ZtFVcDe-9iIkBnYUR3agoqX3-qoXbdKTiyqgnmbL-uwMvd7fP6Idk83T-ubzaJpikaEq5ViUsiESNGE6mFKFCBrGDx0pSCxDYLrrPYp81KIcsskzaNW2JMRmiG6Apczu_Gat5GE4a8rcPU4Fx-ziRLOSUTKGZQexeCNzbvfd0q_5FjlE-28x_b-a_t_Nt2jJ7v_xiL1pT_grPeCFzsgShBNdZHl3X44zjGMpX0C3bqifk</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>PU, L. L. Q</creator><creator>AHMED, S</creator><creator>THOMSON, J. G</creator><creator>REID, M. A</creator><creator>MADSEN, J. A</creator><creator>RESTIFO, R. J</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Endothelial cell growth factor enhances musculocutaneous flap survival through the process of neovascularization</title><author>PU, L. L. Q ; AHMED, S ; THOMSON, J. G ; REID, M. A ; MADSEN, J. A ; RESTIFO, R. 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Graft diseases</topic><topic>Surgical Flaps - blood supply</topic><topic>Tissue Survival - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PU, L. L. Q</creatorcontrib><creatorcontrib>AHMED, S</creatorcontrib><creatorcontrib>THOMSON, J. G</creatorcontrib><creatorcontrib>REID, M. A</creatorcontrib><creatorcontrib>MADSEN, J. A</creatorcontrib><creatorcontrib>RESTIFO, R. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PU, L. L. Q</au><au>AHMED, S</au><au>THOMSON, J. G</au><au>REID, M. A</au><au>MADSEN, J. A</au><au>RESTIFO, R. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial cell growth factor enhances musculocutaneous flap survival through the process of neovascularization</atitle><jtitle>Annals of plastic surgery</jtitle><addtitle>Ann Plast Surg</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>42</volume><issue>3</issue><spage>306</spage><epage>312</epage><pages>306-312</pages><issn>0148-7043</issn><eissn>1536-3708</eissn><coden>APCSD4</coden><abstract>The effect of an angiogenic growth factor-endothelial cell growth factor (ECGF)-was tested in the rat transverse rectus abdominis musculocutaneous (TRAM) flap model based on a single inferior vascular pedicle. The animals were divided into three groups (N = 8 per group) after flap elevation. In group A (control), each animal received both local and local intra-arterial injections of 1 ml saline. In group B (local), each received a 2-mg ECGF local injection and 1-ml saline local intra-arterial injection. In group C (local intra-arterial), each received a 1-ml saline local injection and a 2-mg ECGF local intra-arterial injection. All animals were evaluated on postoperative day 7. There was a significant increase in the percentage of the skin paddle survival area of the TRAM flap in both ECGF-treated groups when compared with the control group (group B vs. group A, p < 0.001; group C vs. group A, p < 0.001). This correlated with a significant increase in vascularity in both ECGF-treated groups compared with the control group (group B vs. group A, p = 0.007; group C vs. group A, p = 0.021). The results between groups B and C were not significant. ECGF, when administered via either local or local intra-arterial route, enhances musculocutaneous flap survival through the process of neovascularization.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10096623</pmid><doi>10.1097/00000637-199903000-00013</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Biological and medical sciences Endothelial Growth Factors - administration & dosage Endothelial Growth Factors - pharmacology Male Medical sciences Miscellaneous Muscle Neovascularization, Physiologic - drug effects Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Rectus Abdominis - blood supply Rectus Abdominis - drug effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Flaps - blood supply Tissue Survival - drug effects |
| title | Endothelial cell growth factor enhances musculocutaneous flap survival through the process of neovascularization |
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