2-Hydroxy-5-nitrobenzyl as a Diazeniumdiolate Protecting Group: Application in NO-Releasing Polymers with Enhanced Biocompatibility

The 2-hydroxy-5-nitrobenzyl group is shown to be an effective protecting group for diazeniumdiolates. O 2-(2-Hydroxy-5-nitrobenzyl)-substituted diazeniumdiolates display enhanced thermal stability, but efficiently release nitric oxide (NO) in pH 7.4 aqueous solutions. A lipophilic analogue incorpora...

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Veröffentlicht in:	Organic letters 2008-10, Vol.10 (20), p.4593-4596
Hauptverfasser:	Xu, Hua, Reynolds, Melissa M, Cook, Keith E, Evans, Anthony S, Toscano, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Azo Compounds - chemistry Biocompatible Materials - chemistry Hydrophobic and Hydrophilic Interactions Hydroxylation Molecular Structure Nitric Oxide - chemistry Nitrobenzenes - chemistry Polymers - chemistry Prodrugs - chemistry Surface Properties
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