N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 ( ) gene in neuroblastoma

Neuronal leucine-rich repeat protein-1 ( NLRR1 ) gene encodes a type I transmembrane protein with unknown function. We have previously described that NLRR1 gene is highly expressed in unfavorable neuroblastomas as compared with favorable tumors and its higher expression levels correlate significantl...

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Veröffentlicht in:	Oncogene 2008-10, Vol.27 (46), p.6075-6082
Hauptverfasser:	Hossain, M S, Ozaki, T, Wang, H, Nakagawa, A, Takenobu, H, Ohira, M, Kamijo, T, Nakagawara, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - genetics c-Myc protein Cell Biology Cell growth Cell lines Cell proliferation Cell Proliferation - drug effects Cellular biology Culture Media, Serum-Free - pharmacology Genes Genetic aspects Genetics Growth rate HeLa Cells Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism Molecular modelling Myc protein Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neuroblastoma Neuroblastoma - genetics Neuroblastoma - pathology Neurosciences Oncology Physiological aspects Proteins Proto-Oncogene Proteins c-myc - physiology Risk factors RNA, Small Interfering - pharmacology short-communication siRNA Transcriptional Activation Transfection Tumor Cells, Cultured Tumors
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