Tuberculin reactivity in a pediatric population with high BCG vaccination coverage
SETTING: The tuberculin skin test (TST) is often included in diagnostic algorithms for tuberculosis (TB) in children. TST interpretation, however, may be complicated by prior Bacillus Calmette-Guérin (BCG) vaccination. We assessed the prevalence of and risk factors for positive TST reactions in chil...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 1999-01, Vol.3 (1), p.23-30 |
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| container_title | The international journal of tuberculosis and lung disease |
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| creator | LOCKMAN, S TAPPERO, J. W KENYON, T. A RUMISHA, D HUEBNER, R. E BINKIN, N. J |
| description | SETTING: The tuberculin skin test (TST) is often included in diagnostic algorithms for tuberculosis (TB) in children. TST interpretation, however, may be complicated by prior Bacillus Calmette-Guérin (BCG) vaccination. We assessed the prevalence of and risk factors for positive
TST reactions in children 3 to 60 months of age in Botswana, a country with high TB rates and BCG coverage of over 90%.METHODS: A multi-stage cluster survey was conducted in one rural and three urban districts. Data collected included demographic characteristics, nutritional indices, vaccination
status, and prior TB exposure. Mantoux TSTs were administered and induration measured at 48-72 hours.RESULTS: Of 821 children identified, 783 had TSTs placed and read. Of the 759 children with vaccination cards, 755 (99.5%) had received BCG vaccine. Seventy-nine per cent of children
had 0 mm induration, 7% had ≥10 mm induration ('positive' TST), and 2% had ≥15 mm. A positive TST was associated with reported contact with any person with active TB (odds ratio [OR] 1.9; 95% confidence interval [CI] 1.02-3.6), or a mother (OR 5.1; 95% CI 2.1-12.4)
or aunt (OR 5.3; 95% CI 2.0-14.0) with active TB. TSTs ≥5 mm (but not ≥10 mm) were associated with presence of a BCG scar. Positive reactions were not associated with age, time since BCG vaccination, clinical signs or symptoms of TB, nutritional status, crowding, or recent measles
or polio immunization.CONCLUSION: The TST remains useful in identifying children with tuberculous infection in this setting of high TB prevalence and extensive BCG coverage. |
| format | Article |
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TST reactions in children 3 to 60 months of age in Botswana, a country with high TB rates and BCG coverage of over 90%.METHODS: A multi-stage cluster survey was conducted in one rural and three urban districts. Data collected included demographic characteristics, nutritional indices, vaccination
status, and prior TB exposure. Mantoux TSTs were administered and induration measured at 48-72 hours.RESULTS: Of 821 children identified, 783 had TSTs placed and read. Of the 759 children with vaccination cards, 755 (99.5%) had received BCG vaccine. Seventy-nine per cent of children
had 0 mm induration, 7% had ≥10 mm induration ('positive' TST), and 2% had ≥15 mm. A positive TST was associated with reported contact with any person with active TB (odds ratio [OR] 1.9; 95% confidence interval [CI] 1.02-3.6), or a mother (OR 5.1; 95% CI 2.1-12.4)
or aunt (OR 5.3; 95% CI 2.0-14.0) with active TB. TSTs ≥5 mm (but not ≥10 mm) were associated with presence of a BCG scar. Positive reactions were not associated with age, time since BCG vaccination, clinical signs or symptoms of TB, nutritional status, crowding, or recent measles
or polio immunization.CONCLUSION: The TST remains useful in identifying children with tuberculous infection in this setting of high TB prevalence and extensive BCG coverage.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>PMID: 10094166</identifier><language>eng</language><publisher>Paris, France: IUATLD</publisher><subject>Bacterial diseases ; BCG Vaccine ; Biological and medical sciences ; Botswana ; Botswana - epidemiology ; Child ; Child, Preschool ; Cluster Analysis ; Diagnosis ; Female ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Mycobacterium Tuberculosis ; Tropical medicine ; Tuberculin Test ; Tuberculosis - diagnosis ; Tuberculosis - epidemiology ; Tuberculosis - prevention & control ; Tuberculosis and atypical mycobacterial infections</subject><ispartof>The international journal of tuberculosis and lung disease, 1999-01, Vol.3 (1), p.23-30</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1936466$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10094166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOCKMAN, S</creatorcontrib><creatorcontrib>TAPPERO, J. W</creatorcontrib><creatorcontrib>KENYON, T. A</creatorcontrib><creatorcontrib>RUMISHA, D</creatorcontrib><creatorcontrib>HUEBNER, R. E</creatorcontrib><creatorcontrib>BINKIN, N. J</creatorcontrib><title>Tuberculin reactivity in a pediatric population with high BCG vaccination coverage</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>SETTING: The tuberculin skin test (TST) is often included in diagnostic algorithms for tuberculosis (TB) in children. TST interpretation, however, may be complicated by prior Bacillus Calmette-Guérin (BCG) vaccination. We assessed the prevalence of and risk factors for positive
TST reactions in children 3 to 60 months of age in Botswana, a country with high TB rates and BCG coverage of over 90%.METHODS: A multi-stage cluster survey was conducted in one rural and three urban districts. Data collected included demographic characteristics, nutritional indices, vaccination
status, and prior TB exposure. Mantoux TSTs were administered and induration measured at 48-72 hours.RESULTS: Of 821 children identified, 783 had TSTs placed and read. Of the 759 children with vaccination cards, 755 (99.5%) had received BCG vaccine. Seventy-nine per cent of children
had 0 mm induration, 7% had ≥10 mm induration ('positive' TST), and 2% had ≥15 mm. A positive TST was associated with reported contact with any person with active TB (odds ratio [OR] 1.9; 95% confidence interval [CI] 1.02-3.6), or a mother (OR 5.1; 95% CI 2.1-12.4)
or aunt (OR 5.3; 95% CI 2.0-14.0) with active TB. TSTs ≥5 mm (but not ≥10 mm) were associated with presence of a BCG scar. Positive reactions were not associated with age, time since BCG vaccination, clinical signs or symptoms of TB, nutritional status, crowding, or recent measles
or polio immunization.CONCLUSION: The TST remains useful in identifying children with tuberculous infection in this setting of high TB prevalence and extensive BCG coverage.</description><subject>Bacterial diseases</subject><subject>BCG Vaccine</subject><subject>Biological and medical sciences</subject><subject>Botswana</subject><subject>Botswana - epidemiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cluster Analysis</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium Tuberculosis</subject><subject>Tropical medicine</subject><subject>Tuberculin Test</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - prevention & control</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1q3DAURk1JadK0r1C8CNkZdGVbtpbtJJkWAoGSrsW1dD2jwSO7-pmQPn1tZoasooX0CR0OXH0fsitooS4aydnFnBlvirIBeZl9DmHHGAeA5lN2CYzJCoS4yn4_p468ToN1uSfU0R5sfM3nG-YTGYvRW51P45QGjHZ0-YuN23xrN9v8x2qdH1Br644vejyQxw19yT72OAT6ejqvsz8P98-rn8Xj0_rX6vtjYUshY4GiqYXmpq1bwbseqReN7jQDZrqqbntoGwQ0HXGgDqnpeUUVGexNi6jLrrzObo_eyY9_E4Wo9jZoGgZ0NKaghBSV4ILN4LcTmLo9GTV5u0f_qs6_MAM3JwCDxqH36LQNb5wsZ9OC3R0x6zbkIqrdmLybR1Q2YRyMsrtlBymlYsdVngMo9HEJ9ax5ek-jz6aluaU4dSgdKD4Xx1peK6gBlKEe0xBVRK82_1Soy_-nZJkZ</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>LOCKMAN, S</creator><creator>TAPPERO, J. W</creator><creator>KENYON, T. A</creator><creator>RUMISHA, D</creator><creator>HUEBNER, R. E</creator><creator>BINKIN, N. J</creator><general>IUATLD</general><general>Union internationale contre la tuberculose et les maladies respiratoires</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>Tuberculin reactivity in a pediatric population with high BCG vaccination coverage</title><author>LOCKMAN, S ; TAPPERO, J. W ; KENYON, T. A ; RUMISHA, D ; HUEBNER, R. E ; BINKIN, N. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i369t-a6756c2d85862bfaef67cbc010db458f187a1adbe21ebae7f24e4edafd8aac3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Bacterial diseases</topic><topic>BCG Vaccine</topic><topic>Biological and medical sciences</topic><topic>Botswana</topic><topic>Botswana - epidemiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cluster Analysis</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mycobacterium Tuberculosis</topic><topic>Tropical medicine</topic><topic>Tuberculin Test</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - prevention & control</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LOCKMAN, S</creatorcontrib><creatorcontrib>TAPPERO, J. W</creatorcontrib><creatorcontrib>KENYON, T. A</creatorcontrib><creatorcontrib>RUMISHA, D</creatorcontrib><creatorcontrib>HUEBNER, R. E</creatorcontrib><creatorcontrib>BINKIN, N. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LOCKMAN, S</au><au>TAPPERO, J. W</au><au>KENYON, T. A</au><au>RUMISHA, D</au><au>HUEBNER, R. E</au><au>BINKIN, N. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuberculin reactivity in a pediatric population with high BCG vaccination coverage</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>3</volume><issue>1</issue><spage>23</spage><epage>30</epage><pages>23-30</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>SETTING: The tuberculin skin test (TST) is often included in diagnostic algorithms for tuberculosis (TB) in children. TST interpretation, however, may be complicated by prior Bacillus Calmette-Guérin (BCG) vaccination. We assessed the prevalence of and risk factors for positive
TST reactions in children 3 to 60 months of age in Botswana, a country with high TB rates and BCG coverage of over 90%.METHODS: A multi-stage cluster survey was conducted in one rural and three urban districts. Data collected included demographic characteristics, nutritional indices, vaccination
status, and prior TB exposure. Mantoux TSTs were administered and induration measured at 48-72 hours.RESULTS: Of 821 children identified, 783 had TSTs placed and read. Of the 759 children with vaccination cards, 755 (99.5%) had received BCG vaccine. Seventy-nine per cent of children
had 0 mm induration, 7% had ≥10 mm induration ('positive' TST), and 2% had ≥15 mm. A positive TST was associated with reported contact with any person with active TB (odds ratio [OR] 1.9; 95% confidence interval [CI] 1.02-3.6), or a mother (OR 5.1; 95% CI 2.1-12.4)
or aunt (OR 5.3; 95% CI 2.0-14.0) with active TB. TSTs ≥5 mm (but not ≥10 mm) were associated with presence of a BCG scar. Positive reactions were not associated with age, time since BCG vaccination, clinical signs or symptoms of TB, nutritional status, crowding, or recent measles
or polio immunization.CONCLUSION: The TST remains useful in identifying children with tuberculous infection in this setting of high TB prevalence and extensive BCG coverage.</abstract><cop>Paris, France</cop><pub>IUATLD</pub><pmid>10094166</pmid><tpages>8</tpages></addata></record> |
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| subjects | Bacterial diseases BCG Vaccine Biological and medical sciences Botswana Botswana - epidemiology Child Child, Preschool Cluster Analysis Diagnosis Female Human bacterial diseases Humans Infant Infectious diseases Male Medical sciences Mycobacterium Tuberculosis Tropical medicine Tuberculin Test Tuberculosis - diagnosis Tuberculosis - epidemiology Tuberculosis - prevention & control Tuberculosis and atypical mycobacterial infections |
| title | Tuberculin reactivity in a pediatric population with high BCG vaccination coverage |
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