Interferon‐β mediates stromal cell rescue of T cells from apoptosis

The resolution of immune responses is characterized by extensive apoptosis of activated T cells. However, to generate and maintain immunological memory, some antigen‐specific T cells must survive and revert to a resting G0 /G1 state. Cytokines that bind to the common γ chain of the IL‐2 receptor pr...

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Veröffentlicht in:	European journal of immunology 1999-03, Vol.29 (3), p.1041-1050
Hauptverfasser:	Pilling, Darrell, Akbar, Arne N., Girdlestone, John, Orteu, Catherine H., Borthwick, Nicola J., Amft, Nicole, Scheel‐Toellner, Dagmar, Buckley, Christopher D., Salmon, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Arthritis, Rheumatoid - immunology DNA-Binding Proteins - metabolism Fibroblasts - drug effects Fibroblasts - immunology Humans Immunophenotyping Interferon Interferon-alpha - immunology Interferon-alpha - pharmacology Interferon-beta - biosynthesis Interferon-beta - immunology Interferon-beta - pharmacology Memory Milk Proteins Signal Transduction - immunology STAT1 Transcription Factor STAT5 Transcription Factor Stromal cell Stromal Cells - cytology Stromal Cells - drug effects Stromal Cells - immunology Synovial Fluid - immunology T lymphocyte T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology Trans-Activators - metabolism
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