Effects of the protein kinase A inhibitor H-89 on Ca2+ regulation in isolated ferret ventricular myocytes

We investigated the effects of a protein kinase A (PKA) inhibitor, H-89 {N-[2-(p-bromocinnamylamino)ethyl]-5-iso-quinolinesulphonamide}, on Ca2+ regulation in Fura-2-loaded ferret myocytes. H-89 (10 micromol/l) decreased the amplitude of the Fura-2 transient to 28. 2+/-4.3% (P

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Bibliographische Detailangaben
Veröffentlicht in:	Pflügers Archiv 1999-03, Vol.437 (4), p.529-537
Hauptverfasser:	Hussain, M, Drago, G A, Bhogal, M, Colyer, J, Orchard, C H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caffeine - pharmacology Calcium - metabolism Calcium-Binding Proteins - metabolism Calcium-Transporting ATPases - antagonists & inhibitors Calcium-Transporting ATPases - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Dogs Enzyme Inhibitors - pharmacology Female Ferrets Heart Ventricles - drug effects Heart Ventricles - enzymology Isoquinolines - pharmacology Kinases Male Microsomes - enzymology Muscle, Skeletal - ultrastructure Muscular system Myocardium - enzymology Phosphorylation Proteins Rats Rodents Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - enzymology Sulfonamides
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Beschreibung
Zusammenfassung:	We investigated the effects of a protein kinase A (PKA) inhibitor, H-89 {N-[2-(p-bromocinnamylamino)ethyl]-5-iso-quinolinesulphonamide}, on Ca2+ regulation in Fura-2-loaded ferret myocytes. H-89 (10 micromol/l) decreased the amplitude of the Fura-2 transient to 28. 2+/-4.3% (P
ISSN:	0031-6768 1432-2013
DOI:	10.1007/s004240050814