Increased oxidative stress in the RAW 264.7 macrophage cell line is partially mediated via the S-nitrosothiol-induced inhibition of glutathione reductase

We investigated whether endogenously or exogenously produced nitric oxide (NO) can inhibit cellular glutathione reductase (GR) via the formation of S-nitrosothiols to decrease cellular glutathione (GSH) and increase oxidative stress in RAW 264.7 cells. The specificity of this inhibition was demonstr...

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Veröffentlicht in:	FEBS letters 1999-02, Vol.445 (2), p.274-278
Hauptverfasser:	Butzer, Urwe, Weidenbach, Hans, Gansauge, Susanne, Gansauge, Frank, Beger, Hans G, Nussler, Andreas K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cysteine - analogs & derivatives Cysteine - metabolism Cysteine - pharmacology Glutathione Glutathione - analogs & derivatives Glutathione - metabolism Glutathione - pharmacology Glutathione reductase Glutathione Reductase - metabolism Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mercaptoethanol Mice Nitric oxide Nitric Oxide - metabolism Nitroso Compounds - metabolism Nitroso Compounds - pharmacology Oxidative stress Oxidative Stress - physiology Reactive Oxygen Species - metabolism S-Nitrosoglutathione S-nitrosothiol S-Nitrosothiols Superoxides - metabolism
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