Temporal, quantitative, and functional characteristics of single-KIR–positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation

In this study, we have characterized reconstitution of the natural killer (NK) cell repertoire after haploidentical CD34+ selected hematopoietic stem cell transplantation (HSCT) for high-risk hematologic malignancies. Analysis focused on alloreactive single-KIR+ NK cells, which reportedly are potent...

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Veröffentlicht in:	Blood 2008-10, Vol.112 (8), p.3488-3499
Hauptverfasser:	Vago, Luca, Forno, Barbara, Sormani, Maria Pia, Crocchiolo, Roberto, Zino, Elisabetta, Di Terlizzi, Simona, Lupo Stanghellini, Maria Teresa, Mazzi, Benedetta, Perna, Serena K., Bondanza, Attilio, Middleton, Derek, Palini, Alessio, Bernardi, Massimo, Bacchetta, Rosa, Peccatori, Jacopo, Rossini, Silvano, Roncarolo, Maria Grazia, Bordignon, Claudio, Bonini, Chiara, Ciceri, Fabio, Fleischhauer, Katharina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antigens, CD34 - biosynthesis Biological and medical sciences CD56 Antigen - biosynthesis Cell Survival Female Graft vs Leukemia Effect Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - methods Humans Killer Cells, Natural - metabolism Kinetics Male Medical sciences Middle Aged Receptors, KIR - genetics Transplantation Conditioning
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