Allogeneic cell-mediated immunotherapy for eradication of minimal residual disease: Comparison of T-cell and IL-2 activated killer (LAK) cell–mediated adoptive immunotherapy in murine models

In the course of allogeneic bone marrow transplantation (BMT), avoiding graft-versus-host disease (GVHD) while retaining the antileukemic effects of the T cells remains a major challenge. T-cell depletion (TCD) reduces the incidence of GVHD but increases the relapse rate after allogeneic BMT. We att...

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