Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis

Background: Several clinical trials have investigated the impact of glucomannan on plasma lipids, body weight, fasting blood glucose (FBG), and blood pressure (BP), but have yielded conflicting results and had only modest sample sizes. Objective: The objective was to perform a meta-analysis of rando...

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Veröffentlicht in:The American journal of clinical nutrition 2008-10, Vol.88 (4), p.1167-1175
Hauptverfasser: Sood, Nitesh, Baker, William L, Coleman, Craig I
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container_title The American journal of clinical nutrition
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creator Sood, Nitesh
Baker, William L
Coleman, Craig I
description Background: Several clinical trials have investigated the impact of glucomannan on plasma lipids, body weight, fasting blood glucose (FBG), and blood pressure (BP), but have yielded conflicting results and had only modest sample sizes. Objective: The objective was to perform a meta-analysis of randomized controlled trials of glucomannan to better characterize its impact on plasma lipids, FBG, body weight, and BP. Design: A systematic literature search of MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane Library, and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through November 2007. A random-effects model was used to calculate the weighted mean difference (WMD) and 95% CIs as the difference between the mean for the glucomannan and control groups. Standard methods for assessing statistical heterogeneity and publication bias were used. Results: Fourteen studies (n = 531) met the inclusion criteria. The use of glucomannan significantly lowered total cholesterol [weighted mean difference (WMD): −19.28 mg/dL; 95% CI: −24.30, −14.26], LDL cholesterol (WMD: −15.99 mg/dL; 95% CI: −21.31, −10.67), triglycerides (WMD: −11.08 mg/dL; 95% CI: −22.07, −0.09), body weight (WMD: −0.79 kg; 95% CI: −1.53, −0.05), and FBG (WMD: −7.44 mg/dL; 95% CI: −14.16, −0.72). The use of glucomannan did not appear to significantly alter any other study endpoints. Pediatric patients, patients receiving dietary modification, and patients with impaired glucose metabolism did not benefit from glucomannan to the same degree. Conclusions: Glucomannan appears to beneficially affect total cholesterol, LDL cholesterol, triglycerides, body weight, and FBG, but not HDL cholesterol or BP.
doi_str_mv 10.1093/ajcn/88.4.1167
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Objective: The objective was to perform a meta-analysis of randomized controlled trials of glucomannan to better characterize its impact on plasma lipids, FBG, body weight, and BP. Design: A systematic literature search of MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane Library, and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through November 2007. A random-effects model was used to calculate the weighted mean difference (WMD) and 95% CIs as the difference between the mean for the glucomannan and control groups. Standard methods for assessing statistical heterogeneity and publication bias were used. Results: Fourteen studies (n = 531) met the inclusion criteria. The use of glucomannan significantly lowered total cholesterol [weighted mean difference (WMD): −19.28 mg/dL; 95% CI: −24.30, −14.26], LDL cholesterol (WMD: −15.99 mg/dL; 95% CI: −21.31, −10.67), triglycerides (WMD: −11.08 mg/dL; 95% CI: −22.07, −0.09), body weight (WMD: −0.79 kg; 95% CI: −1.53, −0.05), and FBG (WMD: −7.44 mg/dL; 95% CI: −14.16, −0.72). The use of glucomannan did not appear to significantly alter any other study endpoints. Pediatric patients, patients receiving dietary modification, and patients with impaired glucose metabolism did not benefit from glucomannan to the same degree. 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Objective: The objective was to perform a meta-analysis of randomized controlled trials of glucomannan to better characterize its impact on plasma lipids, FBG, body weight, and BP. Design: A systematic literature search of MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane Library, and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through November 2007. A random-effects model was used to calculate the weighted mean difference (WMD) and 95% CIs as the difference between the mean for the glucomannan and control groups. Standard methods for assessing statistical heterogeneity and publication bias were used. Results: Fourteen studies (n = 531) met the inclusion criteria. 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Psychology</topic><topic>glucomannans</topic><topic>Glucose</topic><topic>Humans</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>literature reviews</topic><topic>Mannans - pharmacology</topic><topic>Meta-analysis</topic><topic>Plasma</topic><topic>Randomized Controlled Trials as Topic</topic><topic>triacylglycerols</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sood, Nitesh</creatorcontrib><creatorcontrib>Baker, William L</creatorcontrib><creatorcontrib>Coleman, Craig I</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sood, Nitesh</au><au>Baker, William L</au><au>Coleman, Craig I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>88</volume><issue>4</issue><spage>1167</spage><epage>1175</epage><pages>1167-1175</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Background: Several clinical trials have investigated the impact of glucomannan on plasma lipids, body weight, fasting blood glucose (FBG), and blood pressure (BP), but have yielded conflicting results and had only modest sample sizes. Objective: The objective was to perform a meta-analysis of randomized controlled trials of glucomannan to better characterize its impact on plasma lipids, FBG, body weight, and BP. Design: A systematic literature search of MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane Library, and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through November 2007. A random-effects model was used to calculate the weighted mean difference (WMD) and 95% CIs as the difference between the mean for the glucomannan and control groups. Standard methods for assessing statistical heterogeneity and publication bias were used. Results: Fourteen studies (n = 531) met the inclusion criteria. The use of glucomannan significantly lowered total cholesterol [weighted mean difference (WMD): −19.28 mg/dL; 95% CI: −24.30, −14.26], LDL cholesterol (WMD: −15.99 mg/dL; 95% CI: −21.31, −10.67), triglycerides (WMD: −11.08 mg/dL; 95% CI: −22.07, −0.09), body weight (WMD: −0.79 kg; 95% CI: −1.53, −0.05), and FBG (WMD: −7.44 mg/dL; 95% CI: −14.16, −0.72). The use of glucomannan did not appear to significantly alter any other study endpoints. Pediatric patients, patients receiving dietary modification, and patients with impaired glucose metabolism did not benefit from glucomannan to the same degree. Conclusions: Glucomannan appears to beneficially affect total cholesterol, LDL cholesterol, triglycerides, body weight, and FBG, but not HDL cholesterol or BP.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>18842808</pmid><doi>10.1093/ajcn/88.4.1167</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Biological and medical sciences
blood glucose
Blood Glucose - drug effects
Blood Glucose - metabolism
blood lipids
Blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
body weight
Body Weight - drug effects
Body Weight - physiology
chemical concentration
Cholesterol
Cholesterol - blood
Effects
Fasting
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
glucomannans
Glucose
Humans
Lipids
Lipids - blood
literature reviews
Mannans - pharmacology
Meta-analysis
Plasma
Randomized Controlled Trials as Topic
triacylglycerols
Triglycerides - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
title Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis
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