Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis
Background: Several clinical trials have investigated the impact of glucomannan on plasma lipids, body weight, fasting blood glucose (FBG), and blood pressure (BP), but have yielded conflicting results and had only modest sample sizes. Objective: The objective was to perform a meta-analysis of rando...
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description | Background: Several clinical trials have investigated the impact of glucomannan on plasma lipids, body weight, fasting blood glucose (FBG), and blood pressure (BP), but have yielded conflicting results and had only modest sample sizes.
Objective: The objective was to perform a meta-analysis of randomized controlled trials of glucomannan to better characterize its impact on plasma lipids, FBG, body weight, and BP.
Design: A systematic literature search of MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane Library, and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through November 2007. A random-effects model was used to calculate the weighted mean difference (WMD) and 95% CIs as the difference between the mean for the glucomannan and control groups. Standard methods for assessing statistical heterogeneity and publication bias were used.
Results: Fourteen studies (n = 531) met the inclusion criteria. The use of glucomannan significantly lowered total cholesterol [weighted mean difference (WMD): −19.28 mg/dL; 95% CI: −24.30, −14.26], LDL cholesterol (WMD: −15.99 mg/dL; 95% CI: −21.31, −10.67), triglycerides (WMD: −11.08 mg/dL; 95% CI: −22.07, −0.09), body weight (WMD: −0.79 kg; 95% CI: −1.53, −0.05), and FBG (WMD: −7.44 mg/dL; 95% CI: −14.16, −0.72). The use of glucomannan did not appear to significantly alter any other study endpoints. Pediatric patients, patients receiving dietary modification, and patients with impaired glucose metabolism did not benefit from glucomannan to the same degree.
Conclusions: Glucomannan appears to beneficially affect total cholesterol, LDL cholesterol, triglycerides, body weight, and FBG, but not HDL cholesterol or BP. |
doi_str_mv | 10.1093/ajcn/88.4.1167 |
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Objective: The objective was to perform a meta-analysis of randomized controlled trials of glucomannan to better characterize its impact on plasma lipids, FBG, body weight, and BP.
Design: A systematic literature search of MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane Library, and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through November 2007. A random-effects model was used to calculate the weighted mean difference (WMD) and 95% CIs as the difference between the mean for the glucomannan and control groups. Standard methods for assessing statistical heterogeneity and publication bias were used.
Results: Fourteen studies (n = 531) met the inclusion criteria. The use of glucomannan significantly lowered total cholesterol [weighted mean difference (WMD): −19.28 mg/dL; 95% CI: −24.30, −14.26], LDL cholesterol (WMD: −15.99 mg/dL; 95% CI: −21.31, −10.67), triglycerides (WMD: −11.08 mg/dL; 95% CI: −22.07, −0.09), body weight (WMD: −0.79 kg; 95% CI: −1.53, −0.05), and FBG (WMD: −7.44 mg/dL; 95% CI: −14.16, −0.72). The use of glucomannan did not appear to significantly alter any other study endpoints. Pediatric patients, patients receiving dietary modification, and patients with impaired glucose metabolism did not benefit from glucomannan to the same degree.
Conclusions: Glucomannan appears to beneficially affect total cholesterol, LDL cholesterol, triglycerides, body weight, and FBG, but not HDL cholesterol or BP.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/88.4.1167</identifier><identifier>PMID: 18842808</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Biological and medical sciences ; blood glucose ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; blood lipids ; Blood pressure ; Blood Pressure - drug effects ; Blood Pressure - physiology ; body weight ; Body Weight - drug effects ; Body Weight - physiology ; chemical concentration ; Cholesterol ; Cholesterol - blood ; Effects ; Fasting ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; glucomannans ; Glucose ; Humans ; Lipids ; Lipids - blood ; literature reviews ; Mannans - pharmacology ; Meta-analysis ; Plasma ; Randomized Controlled Trials as Topic ; triacylglycerols ; Triglycerides - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The American journal of clinical nutrition, 2008-10, Vol.88 (4), p.1167-1175</ispartof><rights>2008 American Society for Nutrition.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Oct 1, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-1f8e374356b2ddc2f8a9644cd63a6ef7bd78f637d0cd343e2c9b9ce3982610123</citedby><cites>FETCH-LOGICAL-c529t-1f8e374356b2ddc2f8a9644cd63a6ef7bd78f637d0cd343e2c9b9ce3982610123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20775115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18842808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sood, Nitesh</creatorcontrib><creatorcontrib>Baker, William L</creatorcontrib><creatorcontrib>Coleman, Craig I</creatorcontrib><title>Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Background: Several clinical trials have investigated the impact of glucomannan on plasma lipids, body weight, fasting blood glucose (FBG), and blood pressure (BP), but have yielded conflicting results and had only modest sample sizes.
Objective: The objective was to perform a meta-analysis of randomized controlled trials of glucomannan to better characterize its impact on plasma lipids, FBG, body weight, and BP.
Design: A systematic literature search of MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane Library, and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through November 2007. A random-effects model was used to calculate the weighted mean difference (WMD) and 95% CIs as the difference between the mean for the glucomannan and control groups. Standard methods for assessing statistical heterogeneity and publication bias were used.
Results: Fourteen studies (n = 531) met the inclusion criteria. The use of glucomannan significantly lowered total cholesterol [weighted mean difference (WMD): −19.28 mg/dL; 95% CI: −24.30, −14.26], LDL cholesterol (WMD: −15.99 mg/dL; 95% CI: −21.31, −10.67), triglycerides (WMD: −11.08 mg/dL; 95% CI: −22.07, −0.09), body weight (WMD: −0.79 kg; 95% CI: −1.53, −0.05), and FBG (WMD: −7.44 mg/dL; 95% CI: −14.16, −0.72). The use of glucomannan did not appear to significantly alter any other study endpoints. Pediatric patients, patients receiving dietary modification, and patients with impaired glucose metabolism did not benefit from glucomannan to the same degree.
Conclusions: Glucomannan appears to beneficially affect total cholesterol, LDL cholesterol, triglycerides, body weight, and FBG, but not HDL cholesterol or BP.</description><subject>Biological and medical sciences</subject><subject>blood glucose</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>blood lipids</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>body weight</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - physiology</subject><subject>chemical concentration</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Effects</subject><subject>Fasting</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glucomannans</subject><subject>Glucose</subject><subject>Humans</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>literature reviews</subject><subject>Mannans - pharmacology</subject><subject>Meta-analysis</subject><subject>Plasma</subject><subject>Randomized Controlled Trials as Topic</subject><subject>triacylglycerols</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1v1DAQBuAIgehSuHIECwlOzdYfSexwQ1X5kCpxgJ4txx4vXiX24kla7R_gd-PtrkBC4uSDnxnNzFtVLxldM9qLS7O18VKpdbNmrJOPqhXrhaoFp_JxtaKU8rpnXXtWPUPcUsp4o7qn1RlTquGKqlX169p7sDNJnmzGxabJxGgiSZHsRoOTIWPYBUdMdMd_BGJTtBDnbOaQIl6QIbk9uYew-TFfPMBhTMmRXQbEJcN7gnucYSrckgx3Ae4f1ASzqU004x4DPq-eeDMivDi959Xtx-vvV5_rm6-fvlx9uKlty_u5Zl6BkI1ou4E7Z7lXpu-axrpOmA68HJxUvhPSUetEI4DbfugtiF7xjpXtxXn17th3l9PPBXDWU0AL42gipAV1V9oJSlWBb_6B27TkMi1qLsqNZatkQesjsjkhZvB6l8Nk8l4zqg_x6EM8Wind6EM8peDVqesyTOD-8lMeBbw9AYPWjD6baAP-cSVW2TLWFvf66LxJ2mxyMbffOGWCsraRXB42VUcB5Zzl6FmjDVCScyGXwLVL4X9T_gbMvbav</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Sood, Nitesh</creator><creator>Baker, William L</creator><creator>Coleman, Craig I</creator><general>Elsevier Inc</general><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis</title><author>Sood, Nitesh ; Baker, William L ; Coleman, Craig I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-1f8e374356b2ddc2f8a9644cd63a6ef7bd78f637d0cd343e2c9b9ce3982610123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>blood glucose</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>blood lipids</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>body weight</topic><topic>Body Weight - drug effects</topic><topic>Body Weight - physiology</topic><topic>chemical concentration</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Effects</topic><topic>Fasting</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glucomannans</topic><topic>Glucose</topic><topic>Humans</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>literature reviews</topic><topic>Mannans - pharmacology</topic><topic>Meta-analysis</topic><topic>Plasma</topic><topic>Randomized Controlled Trials as Topic</topic><topic>triacylglycerols</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sood, Nitesh</creatorcontrib><creatorcontrib>Baker, William L</creatorcontrib><creatorcontrib>Coleman, Craig I</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sood, Nitesh</au><au>Baker, William L</au><au>Coleman, Craig I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>88</volume><issue>4</issue><spage>1167</spage><epage>1175</epage><pages>1167-1175</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Background: Several clinical trials have investigated the impact of glucomannan on plasma lipids, body weight, fasting blood glucose (FBG), and blood pressure (BP), but have yielded conflicting results and had only modest sample sizes.
Objective: The objective was to perform a meta-analysis of randomized controlled trials of glucomannan to better characterize its impact on plasma lipids, FBG, body weight, and BP.
Design: A systematic literature search of MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane Library, and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through November 2007. A random-effects model was used to calculate the weighted mean difference (WMD) and 95% CIs as the difference between the mean for the glucomannan and control groups. Standard methods for assessing statistical heterogeneity and publication bias were used.
Results: Fourteen studies (n = 531) met the inclusion criteria. The use of glucomannan significantly lowered total cholesterol [weighted mean difference (WMD): −19.28 mg/dL; 95% CI: −24.30, −14.26], LDL cholesterol (WMD: −15.99 mg/dL; 95% CI: −21.31, −10.67), triglycerides (WMD: −11.08 mg/dL; 95% CI: −22.07, −0.09), body weight (WMD: −0.79 kg; 95% CI: −1.53, −0.05), and FBG (WMD: −7.44 mg/dL; 95% CI: −14.16, −0.72). The use of glucomannan did not appear to significantly alter any other study endpoints. Pediatric patients, patients receiving dietary modification, and patients with impaired glucose metabolism did not benefit from glucomannan to the same degree.
Conclusions: Glucomannan appears to beneficially affect total cholesterol, LDL cholesterol, triglycerides, body weight, and FBG, but not HDL cholesterol or BP.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>18842808</pmid><doi>10.1093/ajcn/88.4.1167</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Biological and medical sciences blood glucose Blood Glucose - drug effects Blood Glucose - metabolism blood lipids Blood pressure Blood Pressure - drug effects Blood Pressure - physiology body weight Body Weight - drug effects Body Weight - physiology chemical concentration Cholesterol Cholesterol - blood Effects Fasting Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology glucomannans Glucose Humans Lipids Lipids - blood literature reviews Mannans - pharmacology Meta-analysis Plasma Randomized Controlled Trials as Topic triacylglycerols Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems |
title | Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis |
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