High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan
Borna disease virus (BDV), a negative-strand RNA virus, has been reported to be associated with severe psychiatric disorders. The association is mainly based on the findings that patients with schizophrenia and depression have a higher seroprevalence rate of BDV-specific antibodies than controls. In...
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| Veröffentlicht in: | Molecular psychiatry 1999-01, Vol.4 (1), p.33-38 |
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| creator | Chen, C-H Chiu, Y-L Wei, F-C Koong, F-J Liu, H-C Shaw, C-K Hwu, H-G Hsiao, K-J |
| description | Borna disease virus (BDV), a negative-strand RNA virus, has been reported to be associated with severe psychiatric disorders. The association is mainly based on the findings that patients with schizophrenia and depression have a higher seroprevalence rate of BDV-specific antibodies than controls. In addition, psychiatric patients were also found to have a higher detection rate of BDV transcripts in their blood than controls. By using an improved Western blot analysis, we first demonstrated that Chinese schizophrenic patients from Taiwan also have a higher seroprevalence of BDV-specific antibodies than controls (12.1%
vs
2.9%,
P
|
| doi_str_mv | 10.1038/sj.mp.4000484 |
| format | Article |
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vs
2.9%,
P
< 0.001), providing support to the positive association between bdv and psychiatric disorders in our population. because of the contagious nature of viral infection, we further examined patients' family members and mental health workers, who have close contact with patients. we found that both groups also have a higher seroprevalence of bdv-specific antibodies, 12.1% and 9.8%, respectively, than controls. this finding provides some evidence for a possible human-to-human transmission of borna disease virus. our finding needs further independent verification from other research groups and the clinical relevance of this preliminary observation deserves further study.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/sj.mp.4000484</identifier><identifier>PMID: 10089006</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Adult and adolescent clinical studies ; Antibodies ; Antibodies, Viral - blood ; Behavioral Sciences ; Biological and medical sciences ; Biological Psychology ; Borna disease ; Borna Disease - complications ; Borna Disease - epidemiology ; Borna Disease - immunology ; Borna disease virus ; Borna disease virus - genetics ; Borna disease virus - immunology ; Borna disease virus - isolation & purification ; China - ethnology ; Community Mental Health Services - manpower ; Disease transmission ; Family ; Female ; Humans ; Male ; Medical personnel ; Medical sciences ; Medicine ; Medicine & Public Health ; Mental disorders ; Mental health ; Mental health care ; Neurosciences ; Nuclear Family ; Occupational Therapy ; original-research-article ; Outpatients ; Patients ; Pharmacotherapy ; Prevalence ; Psychiatric Nursing ; Psychiatry ; Psychology, Clinical ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; RNA viruses ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - genetics ; Serologic Tests ; Serology ; Social Work ; Taiwan - epidemiology ; Viral infections</subject><ispartof>Molecular psychiatry, 1999-01, Vol.4 (1), p.33-38</ispartof><rights>Macmillan Publishers Limited 1999</rights><rights>1999 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1999.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-43134ff4f12aeeef39994f99587cbee43d1ff496fae6d3deff479dd47cde93553</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.mp.4000484$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.mp.4000484$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,4010,27904,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1836980$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10089006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, C-H</creatorcontrib><creatorcontrib>Chiu, Y-L</creatorcontrib><creatorcontrib>Wei, F-C</creatorcontrib><creatorcontrib>Koong, F-J</creatorcontrib><creatorcontrib>Liu, H-C</creatorcontrib><creatorcontrib>Shaw, C-K</creatorcontrib><creatorcontrib>Hwu, H-G</creatorcontrib><creatorcontrib>Hsiao, K-J</creatorcontrib><title>High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Borna disease virus (BDV), a negative-strand RNA virus, has been reported to be associated with severe psychiatric disorders. The association is mainly based on the findings that patients with schizophrenia and depression have a higher seroprevalence rate of BDV-specific antibodies than controls. In addition, psychiatric patients were also found to have a higher detection rate of BDV transcripts in their blood than controls. By using an improved Western blot analysis, we first demonstrated that Chinese schizophrenic patients from Taiwan also have a higher seroprevalence of BDV-specific antibodies than controls (12.1%
vs
2.9%,
P
< 0.001), providing support to the positive association between bdv and psychiatric disorders in our population. because of the contagious nature of viral infection, we further examined patients' family members and mental health workers, who have close contact with patients. we found that both groups also have a higher seroprevalence of bdv-specific antibodies, 12.1% and 9.8%, respectively, than controls. this finding provides some evidence for a possible human-to-human transmission of borna disease virus. our finding needs further independent verification from other research groups and the clinical relevance of this preliminary observation deserves further study.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Behavioral Sciences</subject><subject>Biological and medical sciences</subject><subject>Biological Psychology</subject><subject>Borna disease</subject><subject>Borna Disease - complications</subject><subject>Borna Disease - epidemiology</subject><subject>Borna Disease - immunology</subject><subject>Borna disease virus</subject><subject>Borna disease virus - genetics</subject><subject>Borna disease virus - immunology</subject><subject>Borna disease virus - isolation & purification</subject><subject>China - ethnology</subject><subject>Community Mental Health Services - manpower</subject><subject>Disease transmission</subject><subject>Family</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical personnel</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Mental health care</subject><subject>Neurosciences</subject><subject>Nuclear Family</subject><subject>Occupational Therapy</subject><subject>original-research-article</subject><subject>Outpatients</subject><subject>Patients</subject><subject>Pharmacotherapy</subject><subject>Prevalence</subject><subject>Psychiatric Nursing</subject><subject>Psychiatry</subject><subject>Psychology, Clinical</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>RNA viruses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - genetics</subject><subject>Serologic Tests</subject><subject>Serology</subject><subject>Social Work</subject><subject>Taiwan - epidemiology</subject><subject>Viral infections</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rFTEUxYMotlaXbiWguHKeycvHTJa1qBUK3bTrIS9z08lzJhlzZ1rav9483oOKFLrKCefHyc09hLznbMWZaL7idjVOK8kYk418QY65rHWlVN28LFooU0neyCPyBnHL2M5Ur8kRZ6wxjOlj8nAebnqKkNOU4dYOEB3Q5Om3lKOltyEvSEP04OaQYlEUXR8e0tRniMHRyc4B4oxfqLdjGO7pCOMGMlIbu6LjbAfagx3mnt6l_HvnlIwrG-5sfEteeTsgvDucJ-T6x_ers_Pq4vLnr7PTi8pJpeZKCi6k99LztQUAL4wx0hujmtptAKToeHGN9hZ0Jzool9p0naxdB0YoJU7I533ulNOfBXBux4AOhsFGSAu22mhhZFnmcyCv10pyaQr48T9wm5ayrwHbtZaq1muteKGqPeVyQszg2ymH0eb7lrN2112L23ac2kN3hf9wSF02I3T_0PuyCvDpAFh0dvDZRhfwkWuENs3uG6s9hsWJN5Afp3v64b-AebOF</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Chen, C-H</creator><creator>Chiu, Y-L</creator><creator>Wei, F-C</creator><creator>Koong, F-J</creator><creator>Liu, H-C</creator><creator>Shaw, C-K</creator><creator>Hwu, H-G</creator><creator>Hsiao, K-J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan</title><author>Chen, C-H ; Chiu, Y-L ; Wei, F-C ; Koong, F-J ; Liu, H-C ; Shaw, C-K ; Hwu, H-G ; Hsiao, K-J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-43134ff4f12aeeef39994f99587cbee43d1ff496fae6d3deff479dd47cde93553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Behavioral Sciences</topic><topic>Biological and medical sciences</topic><topic>Biological Psychology</topic><topic>Borna disease</topic><topic>Borna Disease - complications</topic><topic>Borna Disease - epidemiology</topic><topic>Borna Disease - immunology</topic><topic>Borna disease virus</topic><topic>Borna disease virus - genetics</topic><topic>Borna disease virus - immunology</topic><topic>Borna disease virus - isolation & purification</topic><topic>China - ethnology</topic><topic>Community Mental Health Services - manpower</topic><topic>Disease transmission</topic><topic>Family</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical personnel</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Mental health care</topic><topic>Neurosciences</topic><topic>Nuclear Family</topic><topic>Occupational Therapy</topic><topic>original-research-article</topic><topic>Outpatients</topic><topic>Patients</topic><topic>Pharmacotherapy</topic><topic>Prevalence</topic><topic>Psychiatric Nursing</topic><topic>Psychiatry</topic><topic>Psychology, Clinical</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>RNA viruses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - genetics</topic><topic>Serologic Tests</topic><topic>Serology</topic><topic>Social Work</topic><topic>Taiwan - epidemiology</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, C-H</creatorcontrib><creatorcontrib>Chiu, Y-L</creatorcontrib><creatorcontrib>Wei, F-C</creatorcontrib><creatorcontrib>Koong, F-J</creatorcontrib><creatorcontrib>Liu, H-C</creatorcontrib><creatorcontrib>Shaw, C-K</creatorcontrib><creatorcontrib>Hwu, H-G</creatorcontrib><creatorcontrib>Hsiao, K-J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, C-H</au><au>Chiu, Y-L</au><au>Wei, F-C</au><au>Koong, F-J</au><au>Liu, H-C</au><au>Shaw, C-K</au><au>Hwu, H-G</au><au>Hsiao, K-J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>4</volume><issue>1</issue><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Borna disease virus (BDV), a negative-strand RNA virus, has been reported to be associated with severe psychiatric disorders. The association is mainly based on the findings that patients with schizophrenia and depression have a higher seroprevalence rate of BDV-specific antibodies than controls. In addition, psychiatric patients were also found to have a higher detection rate of BDV transcripts in their blood than controls. By using an improved Western blot analysis, we first demonstrated that Chinese schizophrenic patients from Taiwan also have a higher seroprevalence of BDV-specific antibodies than controls (12.1%
vs
2.9%,
P
< 0.001), providing support to the positive association between bdv and psychiatric disorders in our population. because of the contagious nature of viral infection, we further examined patients' family members and mental health workers, who have close contact with patients. we found that both groups also have a higher seroprevalence of bdv-specific antibodies, 12.1% and 9.8%, respectively, than controls. this finding provides some evidence for a possible human-to-human transmission of borna disease virus. our finding needs further independent verification from other research groups and the clinical relevance of this preliminary observation deserves further study.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>10089006</pmid><doi>10.1038/sj.mp.4000484</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Antibodies Antibodies, Viral - blood Behavioral Sciences Biological and medical sciences Biological Psychology Borna disease Borna Disease - complications Borna Disease - epidemiology Borna Disease - immunology Borna disease virus Borna disease virus - genetics Borna disease virus - immunology Borna disease virus - isolation & purification China - ethnology Community Mental Health Services - manpower Disease transmission Family Female Humans Male Medical personnel Medical sciences Medicine Medicine & Public Health Mental disorders Mental health Mental health care Neurosciences Nuclear Family Occupational Therapy original-research-article Outpatients Patients Pharmacotherapy Prevalence Psychiatric Nursing Psychiatry Psychology, Clinical Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses RNA viruses Schizophrenia Schizophrenia - complications Schizophrenia - genetics Serologic Tests Serology Social Work Taiwan - epidemiology Viral infections |
| title | High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan |
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