Evaluation of glycine site antagonists of the NMDA receptor in global cerebral ischaemia

In the present studies we have investigated the effects of a range of glycine site antagonists of the N-methyl- d-aspartate (NMDA) receptor in the gerbil model of global cerebral ischaemia. The compounds tested were (+)-3-amino-1-hydroxy-2-pyrrolidone (HA 966, 15 mg/kg), 7-chloro-4-hydroxy-3-(3-phen...

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Veröffentlicht in:	Brain research 1999-02, Vol.819 (1), p.65-74
Hauptverfasser:	Hicks, Caroline A., Ward, Mark A., Ragumoorthy, Nella, Ambler, Samantha J., Dell, Colin P., Dobson, David, O'Neill, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACEA1021 Animals Arterial Occlusive Diseases - complications Biological and medical sciences Carotid Artery Diseases - complications Cell Death - drug effects Cerebral ischaemia Excitatory Amino Acid Antagonists - pharmacology Gerbil Gerbillinae Glycine site antagonist GV150526A Hippocampus - drug effects Hippocampus - metabolism Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - etiology Ischemic Attack, Transient - pathology L-701 LY293558 Male Medical sciences Neurology Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacology Receptors, AMPA - antagonists & inhibitors Receptors, Glycine - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Vascular diseases and vascular malformations of the nervous system
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