Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta

In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept is lacking. Here we describe the initial results of allogeneic bone marrow transplantation in three children with o...

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Veröffentlicht in:	Nature medicine 1999-03, Vol.5 (3), p.309-313
Hauptverfasser:	Horwitz, Edwin M, Prockop, Darwin J, Fitzpatrick, Lorraine A, Koo, Winston W. K, Gordon, Patricia L, Neel, Michael, Sussman, Michael, Orchard, Paul, Marx, Jeffrey C, Pyeritz, Reed E, Brenner, Malcolm K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Bone Density Bone Marrow Cells - cytology Bone Marrow Transplantation - adverse effects Cancer Research Child, Preschool Female Hematopoietic Stem Cells - cytology Humans Infant Infectious Diseases Male Mesoderm - cytology Metabolic Diseases Molecular Medicine Neurosciences Osteoblasts - cytology Osteogenesis - physiology Osteogenesis Imperfecta - therapy Stem Cells - cytology
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