Chlamydia trachomatis Infections: Progress and Problems
Chlamydia trachomatis infections are the most common bacterial sexually transmitted disease in the United States. A substantial proportion of initial infections in both men and women are asymptomatic. Use of nucleic acid amplification-based diagnostic tests on first-void urine makes it possible to i...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 1999-03, Vol.179 (Supplement-2), p.S380-S383 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S383 |
|---|---|
| container_issue | Supplement-2 |
| container_start_page | S380 |
| container_title | The Journal of infectious diseases |
| container_volume | 179 |
| creator | Stamm, Walter E. |
| description | Chlamydia trachomatis infections are the most common bacterial sexually transmitted disease in the United States. A substantial proportion of initial infections in both men and women are asymptomatic. Use of nucleic acid amplification-based diagnostic tests on first-void urine makes it possible to initiate community-based screening programs aimed at identifying asymptomatically infected men and women. Directly observed single-dose therapy with azithromycin is now available. Screening programs have been demonstrated to reduce the overall prevalence of chlamydial infection in the tested population and to reduce the incidence of subsequent pelvic inflammatory disease in previously screened women. The sequelae of chlamydial infections are likely due to immunopathologically mediated events in which both the chlamydial 60 kDa heat-shock protein and genetic predisposition of specific patients play a role. An improved understanding of immunologic events leading to upper genital tract scarring is needed to target specific interventions and facilitate development of a vaccine. |
| doi_str_mv | 10.1086/513844 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_69633766</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30114306</jstor_id><sourcerecordid>30114306</sourcerecordid><originalsourceid>FETCH-LOGICAL-c517t-f6f54e7831b0702c827f5182274fbae7db9a06b92a0a3bb2afd223903d777c2a3</originalsourceid><addsrcrecordid>eNqFkM1LHEEQxZuQEDeb5D9QFgm5TVLVPd01k5tsPhREPSiEXJqanm6dzXyY7lmI_727mUXFSy5VFO_HK94T4j3CJ4TCfNaoijx_IWaoFWXGoHopZgBSZliU5Z54k9IKAHJl6LXYQ4ACNeJM0PKm5e6ubngxRnY3Q8djkxYnffBubIY-fVlcxOE6-pQW3Nfbo2p9l96KV4Hb5N_t9lxcff92uTzOTs9_nCyPTjOnkcYsmKBzT4XCCgikKyQFjYWUlIeKPdVVyWCqUjKwqirJoZZSlaBqInKS1Vx8nHxv4_Bn7dNouyY537bc-2GdrCmNUmTMf0EkpZXZzLk4fAauhnXsNyHsv9dkND26uTikFH2wt7HpON5ZBLst3E6Fb8CDndu66nz9BJsa3gAfdgAnx22I3LsmPXKk5TbDXOxP2CqNQ3yQFSDmCrZ6NulNGv3fB53jb2tIkbbHP3_Z3HyFM9KlvVT3g1Ocww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223907657</pqid></control><display><type>article</type><title>Chlamydia trachomatis Infections: Progress and Problems</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Stamm, Walter E.</creator><creatorcontrib>Stamm, Walter E.</creatorcontrib><description>Chlamydia trachomatis infections are the most common bacterial sexually transmitted disease in the United States. A substantial proportion of initial infections in both men and women are asymptomatic. Use of nucleic acid amplification-based diagnostic tests on first-void urine makes it possible to initiate community-based screening programs aimed at identifying asymptomatically infected men and women. Directly observed single-dose therapy with azithromycin is now available. Screening programs have been demonstrated to reduce the overall prevalence of chlamydial infection in the tested population and to reduce the incidence of subsequent pelvic inflammatory disease in previously screened women. The sequelae of chlamydial infections are likely due to immunopathologically mediated events in which both the chlamydial 60 kDa heat-shock protein and genetic predisposition of specific patients play a role. An improved understanding of immunologic events leading to upper genital tract scarring is needed to target specific interventions and facilitate development of a vaccine.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/513844</identifier><identifier>PMID: 10081511</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University Chicago Press</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Antibodies ; azithromycin ; Azithromycin - therapeutic use ; Bacterial diseases ; Bacterial diseases of the genital system ; Bacteriology ; Biological and medical sciences ; Chlamydia ; Chlamydia Infections - diagnosis ; Chlamydia Infections - drug therapy ; Chlamydia Infections - etiology ; Chlamydia trachomatis ; Chlamydia trachomatis - genetics ; Chlamydia trachomatis - immunology ; Chlamydia trachomatis - isolation & purification ; DNA, Bacterial - genetics ; DNA, Bacterial - isolation & purification ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic screening ; Genitalia ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Male ; Mass Screening ; Medical sciences ; Men ; Microbiology ; Pelvic inflammatory disease ; Sexually transmitted diseases ; USA</subject><ispartof>The Journal of infectious diseases, 1999-03, Vol.179 (Supplement-2), p.S380-S383</ispartof><rights>Copyright 1999 The Infectious Diseases Society of America</rights><rights>1999 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Mar 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-f6f54e7831b0702c827f5182274fbae7db9a06b92a0a3bb2afd223903d777c2a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30114306$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30114306$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1752696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10081511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stamm, Walter E.</creatorcontrib><title>Chlamydia trachomatis Infections: Progress and Problems</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Chlamydia trachomatis infections are the most common bacterial sexually transmitted disease in the United States. A substantial proportion of initial infections in both men and women are asymptomatic. Use of nucleic acid amplification-based diagnostic tests on first-void urine makes it possible to initiate community-based screening programs aimed at identifying asymptomatically infected men and women. Directly observed single-dose therapy with azithromycin is now available. Screening programs have been demonstrated to reduce the overall prevalence of chlamydial infection in the tested population and to reduce the incidence of subsequent pelvic inflammatory disease in previously screened women. The sequelae of chlamydial infections are likely due to immunopathologically mediated events in which both the chlamydial 60 kDa heat-shock protein and genetic predisposition of specific patients play a role. An improved understanding of immunologic events leading to upper genital tract scarring is needed to target specific interventions and facilitate development of a vaccine.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibodies</subject><subject>azithromycin</subject><subject>Azithromycin - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the genital system</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Chlamydia</subject><subject>Chlamydia Infections - diagnosis</subject><subject>Chlamydia Infections - drug therapy</subject><subject>Chlamydia Infections - etiology</subject><subject>Chlamydia trachomatis</subject><subject>Chlamydia trachomatis - genetics</subject><subject>Chlamydia trachomatis - immunology</subject><subject>Chlamydia trachomatis - isolation & purification</subject><subject>DNA, Bacterial - genetics</subject><subject>DNA, Bacterial - isolation & purification</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic screening</subject><subject>Genitalia</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Microbiology</subject><subject>Pelvic inflammatory disease</subject><subject>Sexually transmitted diseases</subject><subject>USA</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LHEEQxZuQEDeb5D9QFgm5TVLVPd01k5tsPhREPSiEXJqanm6dzXyY7lmI_727mUXFSy5VFO_HK94T4j3CJ4TCfNaoijx_IWaoFWXGoHopZgBSZliU5Z54k9IKAHJl6LXYQ4ACNeJM0PKm5e6ubngxRnY3Q8djkxYnffBubIY-fVlcxOE6-pQW3Nfbo2p9l96KV4Hb5N_t9lxcff92uTzOTs9_nCyPTjOnkcYsmKBzT4XCCgikKyQFjYWUlIeKPdVVyWCqUjKwqirJoZZSlaBqInKS1Vx8nHxv4_Bn7dNouyY537bc-2GdrCmNUmTMf0EkpZXZzLk4fAauhnXsNyHsv9dkND26uTikFH2wt7HpON5ZBLst3E6Fb8CDndu66nz9BJsa3gAfdgAnx22I3LsmPXKk5TbDXOxP2CqNQ3yQFSDmCrZ6NulNGv3fB53jb2tIkbbHP3_Z3HyFM9KlvVT3g1Ocww</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Stamm, Walter E.</creator><general>University Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Chlamydia trachomatis Infections: Progress and Problems</title><author>Stamm, Walter E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-f6f54e7831b0702c827f5182274fbae7db9a06b92a0a3bb2afd223903d777c2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibodies</topic><topic>azithromycin</topic><topic>Azithromycin - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the genital system</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Chlamydia</topic><topic>Chlamydia Infections - diagnosis</topic><topic>Chlamydia Infections - drug therapy</topic><topic>Chlamydia Infections - etiology</topic><topic>Chlamydia trachomatis</topic><topic>Chlamydia trachomatis - genetics</topic><topic>Chlamydia trachomatis - immunology</topic><topic>Chlamydia trachomatis - isolation & purification</topic><topic>DNA, Bacterial - genetics</topic><topic>DNA, Bacterial - isolation & purification</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic screening</topic><topic>Genitalia</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Microbiology</topic><topic>Pelvic inflammatory disease</topic><topic>Sexually transmitted diseases</topic><topic>USA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stamm, Walter E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stamm, Walter E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chlamydia trachomatis Infections: Progress and Problems</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>179</volume><issue>Supplement-2</issue><spage>S380</spage><epage>S383</epage><pages>S380-S383</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Chlamydia trachomatis infections are the most common bacterial sexually transmitted disease in the United States. A substantial proportion of initial infections in both men and women are asymptomatic. Use of nucleic acid amplification-based diagnostic tests on first-void urine makes it possible to initiate community-based screening programs aimed at identifying asymptomatically infected men and women. Directly observed single-dose therapy with azithromycin is now available. Screening programs have been demonstrated to reduce the overall prevalence of chlamydial infection in the tested population and to reduce the incidence of subsequent pelvic inflammatory disease in previously screened women. The sequelae of chlamydial infections are likely due to immunopathologically mediated events in which both the chlamydial 60 kDa heat-shock protein and genetic predisposition of specific patients play a role. An improved understanding of immunologic events leading to upper genital tract scarring is needed to target specific interventions and facilitate development of a vaccine.</abstract><cop>Chicago, IL</cop><pub>University Chicago Press</pub><pmid>10081511</pmid><doi>10.1086/513844</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1999-03, Vol.179 (Supplement-2), p.S380-S383 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69633766 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Anti-Bacterial Agents - therapeutic use Antibodies azithromycin Azithromycin - therapeutic use Bacterial diseases Bacterial diseases of the genital system Bacteriology Biological and medical sciences Chlamydia Chlamydia Infections - diagnosis Chlamydia Infections - drug therapy Chlamydia Infections - etiology Chlamydia trachomatis Chlamydia trachomatis - genetics Chlamydia trachomatis - immunology Chlamydia trachomatis - isolation & purification DNA, Bacterial - genetics DNA, Bacterial - isolation & purification Epidemiology Female Fundamental and applied biological sciences. Psychology Genetic screening Genitalia Human bacterial diseases Humans Infections Infectious diseases Male Mass Screening Medical sciences Men Microbiology Pelvic inflammatory disease Sexually transmitted diseases USA |
| title | Chlamydia trachomatis Infections: Progress and Problems |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T12%3A16%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chlamydia%20trachomatis%20Infections:%20Progress%20and%20Problems&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Stamm,%20Walter%20E.&rft.date=1999-03-01&rft.volume=179&rft.issue=Supplement-2&rft.spage=S380&rft.epage=S383&rft.pages=S380-S383&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/513844&rft_dat=%3Cjstor_proqu%3E30114306%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223907657&rft_id=info:pmid/10081511&rft_jstor_id=30114306&rfr_iscdi=true |