Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension
Ratio of stroke volume (SV, M-mode echocardiography) to pulse pressure (PP) has been proposed as an estimate of total arterial compliance and has been shown to be related to body size, age, and heart rate in normal adults. SV/PP was estimated in 294 hypertensive patients (98 women) as a raw value by...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-03, Vol.33 (3), p.800-805 |
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| creator | de Simone, Giovanni Roman, Mary J Koren, Michael J Mensah, George A Ganau, Antonello Devereux, Richard B |
| description | Ratio of stroke volume (SV, M-mode echocardiography) to pulse pressure (PP) has been proposed as an estimate of total arterial compliance and has been shown to be related to body size, age, and heart rate in normal adults. SV/PP was estimated in 294 hypertensive patients (98 women) as a raw value by use of SV/body surface area (SVi) and by the ratio of SV/PP to the value predicted by a previously developed equation (%SV/PP). At baseline, the 50 patients who had cardiovascular events over the following 10 years exhibited higher PP and lower SV/PP, SVi/PP, and %SV/PP (all P |
| doi_str_mv | 10.1161/01.hyp.33.3.800 |
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SV/PP was estimated in 294 hypertensive patients (98 women) as a raw value by use of SV/body surface area (SVi) and by the ratio of SV/PP to the value predicted by a previously developed equation (%SV/PP). At baseline, the 50 patients who had cardiovascular events over the following 10 years exhibited higher PP and lower SV/PP, SVi/PP, and %SV/PP (all P<0.008) than patients without events. Crude risk of follow-up total and fatal cardiovascular events increased with increasing level of PP and decreasing SV/PP, SVi/PP, and %SV/PP (all P<0.002). In multivariate logistic regression models with continuous covariates, the risk of total cardiovascular events was independently related to increasing age (P<0.0001) and left ventricular (LV) mass index (P<0.003) and decreasing values of %SV/PP (P<0.006) but not to increasing systolic, pulse, or mean blood pressure or gender. Similar although less strong results were obtained with the use of SVi/PP (P<0.02), whereas SV/PP did not enter the model as an independent predictor. Risk of cardiovascular death was only predicted by age and LV mass index. The %SV/PP was also an independent predictor of total cardiovascular events in Cox proportional hazards analysis (exp[b]2.49, P<0.001) independent of age (exp[b]1.05, P<0.003) and LV mass index (exp[b]1.02, P<0.0003), whereas no effect was detected for height. Thus, in patients with arterial hypertension, a reduced ratio of M-mode echocardiographic SV/PP as a percentage of the value predicted by demographic variables is a predictor of cardiovascular morbid events independent of age and LV mass index. (Hypertension. 1999;33:800-805.)]]></description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.hyp.33.3.800</identifier><identifier>PMID: 10082490</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Age Factors ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Body Mass Index ; Cardiology. Vascular system ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - diagnosis ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Echocardiography ; Female ; Follow-Up Studies ; Humans ; Hypertension - complications ; Hypertension - physiopathology ; Hypertrophy, Left Ventricular - complications ; Hypertrophy, Left Ventricular - diagnosis ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Sex Factors ; Stroke Volume</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1999-03, Vol.33 (3), p.800-805</ispartof><rights>1999 American Heart Association, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. 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SV/PP was estimated in 294 hypertensive patients (98 women) as a raw value by use of SV/body surface area (SVi) and by the ratio of SV/PP to the value predicted by a previously developed equation (%SV/PP). At baseline, the 50 patients who had cardiovascular events over the following 10 years exhibited higher PP and lower SV/PP, SVi/PP, and %SV/PP (all P<0.008) than patients without events. Crude risk of follow-up total and fatal cardiovascular events increased with increasing level of PP and decreasing SV/PP, SVi/PP, and %SV/PP (all P<0.002). In multivariate logistic regression models with continuous covariates, the risk of total cardiovascular events was independently related to increasing age (P<0.0001) and left ventricular (LV) mass index (P<0.003) and decreasing values of %SV/PP (P<0.006) but not to increasing systolic, pulse, or mean blood pressure or gender. Similar although less strong results were obtained with the use of SVi/PP (P<0.02), whereas SV/PP did not enter the model as an independent predictor. Risk of cardiovascular death was only predicted by age and LV mass index. The %SV/PP was also an independent predictor of total cardiovascular events in Cox proportional hazards analysis (exp[b]2.49, P<0.001) independent of age (exp[b]1.05, P<0.003) and LV mass index (exp[b]1.02, P<0.0003), whereas no effect was detected for height. Thus, in patients with arterial hypertension, a reduced ratio of M-mode echocardiographic SV/PP as a percentage of the value predicted by demographic variables is a predictor of cardiovascular morbid events independent of age and LV mass index. (Hypertension. 1999;33:800-805.)]]></description><subject>Age Factors</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - physiopathology</subject><subject>Hypertrophy, Left Ventricular - complications</subject><subject>Hypertrophy, Left Ventricular - diagnosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Stroke Volume</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0MGL1DAUBvAgijuunr1JEfHWzntJmjbHZVBHWHDYVdFTeNumTHYyzZi0LvPfm2UGFHNJXvjlI3yMvUaoEBUuAavt8VAJUYmqBXjCFlhzWcpaiadsAahlqRF_XLAXKd0DoJSyec4uEKDlUsOC3d5OMexs8T34eW-Xm9knW2yiTWmOtrihyYWCxr5YUexd-E2pmz3F4salXeHG4ipONjryxfp4sPk8JhfGl-zZQDnn1Xm_ZN8-fvi6WpfXXz59Xl1dl10N2JSaOt20RO0dCA4WtRraRnWkiQA59h2v2w40tVrLWvTK2qGRjeWCpCSlB3HJ3p9yDzH8mm2azN6lznpPow1zMkorISSvM3z7H7wPcxzz3wyHmusGlcpoeUJdDClFO5hDdHuKR4NgHss2gGb9c2OEMMLksvOLN-fY-W5v-3_8qd0M3p1B7o38EGnsXPrrGsm5kJnJE3sIPteZdn5-sNFsLflpayAvyVVbotY5M0_l41Uj_gBVZ5Yc</recordid><startdate>199903</startdate><enddate>199903</enddate><creator>de Simone, Giovanni</creator><creator>Roman, Mary J</creator><creator>Koren, Michael J</creator><creator>Mensah, George A</creator><creator>Ganau, Antonello</creator><creator>Devereux, Richard B</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199903</creationdate><title>Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension</title><author>de Simone, Giovanni ; Roman, Mary J ; Koren, Michael J ; Mensah, George A ; Ganau, Antonello ; Devereux, Richard B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5017-9ac978aa8b0320e196f876ca9aa0121dc258c09a899453d6eef747e23a44a69f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Age Factors</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - physiopathology</topic><topic>Hypertrophy, Left Ventricular - complications</topic><topic>Hypertrophy, Left Ventricular - diagnosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Stroke Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Simone, Giovanni</creatorcontrib><creatorcontrib>Roman, Mary J</creatorcontrib><creatorcontrib>Koren, Michael J</creatorcontrib><creatorcontrib>Mensah, George A</creatorcontrib><creatorcontrib>Ganau, Antonello</creatorcontrib><creatorcontrib>Devereux, Richard B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Simone, Giovanni</au><au>Roman, Mary J</au><au>Koren, Michael J</au><au>Mensah, George A</au><au>Ganau, Antonello</au><au>Devereux, Richard B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1999-03</date><risdate>1999</risdate><volume>33</volume><issue>3</issue><spage>800</spage><epage>805</epage><pages>800-805</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract><![CDATA[Ratio of stroke volume (SV, M-mode echocardiography) to pulse pressure (PP) has been proposed as an estimate of total arterial compliance and has been shown to be related to body size, age, and heart rate in normal adults. SV/PP was estimated in 294 hypertensive patients (98 women) as a raw value by use of SV/body surface area (SVi) and by the ratio of SV/PP to the value predicted by a previously developed equation (%SV/PP). At baseline, the 50 patients who had cardiovascular events over the following 10 years exhibited higher PP and lower SV/PP, SVi/PP, and %SV/PP (all P<0.008) than patients without events. Crude risk of follow-up total and fatal cardiovascular events increased with increasing level of PP and decreasing SV/PP, SVi/PP, and %SV/PP (all P<0.002). In multivariate logistic regression models with continuous covariates, the risk of total cardiovascular events was independently related to increasing age (P<0.0001) and left ventricular (LV) mass index (P<0.003) and decreasing values of %SV/PP (P<0.006) but not to increasing systolic, pulse, or mean blood pressure or gender. Similar although less strong results were obtained with the use of SVi/PP (P<0.02), whereas SV/PP did not enter the model as an independent predictor. Risk of cardiovascular death was only predicted by age and LV mass index. The %SV/PP was also an independent predictor of total cardiovascular events in Cox proportional hazards analysis (exp[b]2.49, P<0.001) independent of age (exp[b]1.05, P<0.003) and LV mass index (exp[b]1.02, P<0.0003), whereas no effect was detected for height. Thus, in patients with arterial hypertension, a reduced ratio of M-mode echocardiographic SV/PP as a percentage of the value predicted by demographic variables is a predictor of cardiovascular morbid events independent of age and LV mass index. (Hypertension. 1999;33:800-805.)]]></abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>10082490</pmid><doi>10.1161/01.hyp.33.3.800</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Body Mass Index Cardiology. Vascular system Cardiovascular Diseases - complications Cardiovascular Diseases - diagnosis Clinical manifestations. Epidemiology. Investigative techniques. Etiology Echocardiography Female Follow-Up Studies Humans Hypertension - complications Hypertension - physiopathology Hypertrophy, Left Ventricular - complications Hypertrophy, Left Ventricular - diagnosis Male Medical sciences Middle Aged Multivariate Analysis Risk Factors Sex Factors Stroke Volume |
| title | Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension |
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