Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis

The use of type I interferons (IFNs) in cancer therapy has been limited by ineffective dosing and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2-expressing monocytes (TEMs) to deliver IFN-α to tumors. By transplanting hematopoietic progenitors transduced with...

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Veröffentlicht in:	Cancer cell 2008-10, Vol.14 (4), p.299-311
Hauptverfasser:	De Palma, Michele, Mazzieri, Roberta, Politi, Letterio S., Pucci, Ferdinando, Zonari, Erika, Sitia, Giovanni, Mazzoleni, Stefania, Moi, Davide, Venneri, Mary Anna, Indraccolo, Stefano, Falini, Andrea, Guidotti, Luca G., Galli, Rossella, Naldini, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Proliferation CELLCYCLE Cells, Cultured Female Genetic Therapy - methods Glioma - genetics Glioma - immunology Glioma - metabolism Glioma - pathology Glioma - therapy Hematopoiesis Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - metabolism Humans Immunity, Innate Interferon-alpha - genetics Interferon-alpha - metabolism Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - prevention & control Mice Mice, Nude Mice, Transgenic Monocytes - metabolism Monocytes - transplantation Neoplasm Metastasis Neovascularization, Pathologic - immunology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - prevention & control Promoter Regions, Genetic Receptor, TIE-2 - genetics Receptor, TIE-2 - metabolism Recombinant Fusion Proteins - metabolism Time Factors Transduction, Genetic Wound Healing
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