Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II: Model Studies

Ca transients measured in failing human ventricular myocytes exhibit reduced amplitude, slowed relaxation, and blunted frequency dependence. In the companion article (O'Rourke B, Kass DA, Tomaselli GF, Kaab S, Tunin R, Marban E. Mechanisms of altered excitation-contraction coupling in canine ta...

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Veröffentlicht in:	Circulation research 1999-03, Vol.84 (5), p.571-586
Hauptverfasser:	Winslow, Raimond L, Rice, Jeremy, Jafri, Saleet, Marban, Eduardo, O'Rourke, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Biological and medical sciences Calcium - metabolism Calcium Channels - physiology Calcium-Transporting ATPases - antagonists & inhibitors Calcium-Transporting ATPases - metabolism Cardiology. Vascular system Dinucleoside Phosphates - pharmacology Dogs Enzyme Inhibitors - pharmacology Heart Heart Failure - metabolism Heart Failure - physiopathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Ion Channel Gating Medical sciences Models, Cardiovascular Myocardial Contraction Myocardium - metabolism Myocardium - pathology Patch-Clamp Techniques Potassium Channels - physiology Sarcoplasmic Reticulum - metabolism Sodium - metabolism Sodium-Calcium Exchanger - metabolism
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