Protective effect of aprotinin on ischemia-reperfusion injury in rat ovary
Aim: We investigated the effects of aprotinin on reperfusion injury in a controlled experimental rat torsion–detorsion model. Methods: Thirty‐two female Sprague–Dawley rats were divided into four groups. Sham operation was performed in group I; in group II only ovarian torsion was performed. In gr...
Gespeichert in:
| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2008-10, Vol.34 (5), p.794-800 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 800 |
|---|---|
| container_issue | 5 |
| container_start_page | 794 |
| container_title | The journal of obstetrics and gynaecology research |
| container_volume | 34 |
| creator | Sahin, Figen Kir Cosar, Emine Koken, Gulengul Toy, Hatice Basarali, Kemal Buyukbas, Sadik |
| description | Aim: We investigated the effects of aprotinin on reperfusion injury in a controlled experimental rat torsion–detorsion model.
Methods: Thirty‐two female Sprague–Dawley rats were divided into four groups. Sham operation was performed in group I; in group II only ovarian torsion was performed. In group III, torsion–detorsion was performed, plus 3 mL/kg saline was injected i.v. 30 min before detorsion. In group IV, torsion–detorsion was performed, plus aprotinin (30 000 KIU/kg) was injected 30 min before detorsion. Rats in the torsion group were killed after 360° clockwise adnexial torsion for 3 h, and the ovaries were harvested. After 3 h of adnexial detorsion, the rats in the saline and aprotinin groups were killed and the adnexa were surgically removed.
Results: Ovarian tissue damage scores were significantly different among groups. Ovarian tissue and serum malondialdehyde levels in group III were significantly higher than those of groups I and IV (P 0.05).
Conclusions: Aprotinin attenuates ischemia–reperfusion injury in a rat adnexial torsion–detorsion model. |
| doi_str_mv | 10.1111/j.1447-0756.2008.00846.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69631207</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69631207</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4576-4fbb22371901bc8da1d35c84369f1c14dd36314cdc71b4c8634df1c5845dc4233</originalsourceid><addsrcrecordid>eNqNkMFOwzAMhiMEYmPwCqgnbi1JkyaZxAUmKIyJcRhC4hK1aSoytnYk7djeHpdNcCVSZMv-P9v6EQoIjgi8y3lEGBMhFgmPYoxlBJ_xaHOA-r-NQ8gpI6HEgvfQifdzjIkYEnmMekRKyijlfTR-dnVjdGPXJjBlCVlQl0G2gqqtbBXUVWC9fjdLm4XOrIwrW2-7YjVv3RZC4DJA1pnbnqKjMlt4c7aPA_Rydzsb3YeTafowup6EmiWCh6zM8zimggwxybUsMlLQREtG-bAkmrCioJwSpgstSM605JQV0EgkSwrNYkoH6GI3F478bI1v1BJONItFVpm69YoPgY-xAKHcCbWrvXemVCtnl3CpIlh1Pqq56uxSnV2q81H9-Kg2gJ7vd7T50hR_4N44EFztBF92Ybb_HqzG0xQSwMMdbn1jNr945j4UF1Qk6vUpVW9pTMd49qhu6Dd_k5A2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69631207</pqid></control><display><type>article</type><title>Protective effect of aprotinin on ischemia-reperfusion injury in rat ovary</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Sahin, Figen Kir ; Cosar, Emine ; Koken, Gulengul ; Toy, Hatice ; Basarali, Kemal ; Buyukbas, Sadik</creator><creatorcontrib>Sahin, Figen Kir ; Cosar, Emine ; Koken, Gulengul ; Toy, Hatice ; Basarali, Kemal ; Buyukbas, Sadik</creatorcontrib><description>Aim: We investigated the effects of aprotinin on reperfusion injury in a controlled experimental rat torsion–detorsion model.
Methods: Thirty‐two female Sprague–Dawley rats were divided into four groups. Sham operation was performed in group I; in group II only ovarian torsion was performed. In group III, torsion–detorsion was performed, plus 3 mL/kg saline was injected i.v. 30 min before detorsion. In group IV, torsion–detorsion was performed, plus aprotinin (30 000 KIU/kg) was injected 30 min before detorsion. Rats in the torsion group were killed after 360° clockwise adnexial torsion for 3 h, and the ovaries were harvested. After 3 h of adnexial detorsion, the rats in the saline and aprotinin groups were killed and the adnexa were surgically removed.
Results: Ovarian tissue damage scores were significantly different among groups. Ovarian tissue and serum malondialdehyde levels in group III were significantly higher than those of groups I and IV (P < 0.05). The serum levels of superoxide dismutase in group III were significantly lower than those of groups I and IV (P = 0.01). Tissue and serum xanthine oxidase, nitric oxide, and tissue superoxide dismutase levels were comparable among groups (P > 0.05).
Conclusions: Aprotinin attenuates ischemia–reperfusion injury in a rat adnexial torsion–detorsion model.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/j.1447-0756.2008.00846.x</identifier><identifier>PMID: 18834336</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Animals ; aprotinin ; Aprotinin - pharmacology ; Female ; Hemostatics - pharmacology ; Histocytochemistry ; ischemia-reperfusion injury ; ovary ; Ovary - blood supply ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury - blood ; Reperfusion Injury - prevention & control ; torsion</subject><ispartof>The journal of obstetrics and gynaecology research, 2008-10, Vol.34 (5), p.794-800</ispartof><rights>2008 The Authors. Journal compilation © 2008 Japan Society of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4576-4fbb22371901bc8da1d35c84369f1c14dd36314cdc71b4c8634df1c5845dc4233</citedby><cites>FETCH-LOGICAL-c4576-4fbb22371901bc8da1d35c84369f1c14dd36314cdc71b4c8634df1c5845dc4233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1447-0756.2008.00846.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1447-0756.2008.00846.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18834336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, Figen Kir</creatorcontrib><creatorcontrib>Cosar, Emine</creatorcontrib><creatorcontrib>Koken, Gulengul</creatorcontrib><creatorcontrib>Toy, Hatice</creatorcontrib><creatorcontrib>Basarali, Kemal</creatorcontrib><creatorcontrib>Buyukbas, Sadik</creatorcontrib><title>Protective effect of aprotinin on ischemia-reperfusion injury in rat ovary</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim: We investigated the effects of aprotinin on reperfusion injury in a controlled experimental rat torsion–detorsion model.
Methods: Thirty‐two female Sprague–Dawley rats were divided into four groups. Sham operation was performed in group I; in group II only ovarian torsion was performed. In group III, torsion–detorsion was performed, plus 3 mL/kg saline was injected i.v. 30 min before detorsion. In group IV, torsion–detorsion was performed, plus aprotinin (30 000 KIU/kg) was injected 30 min before detorsion. Rats in the torsion group were killed after 360° clockwise adnexial torsion for 3 h, and the ovaries were harvested. After 3 h of adnexial detorsion, the rats in the saline and aprotinin groups were killed and the adnexa were surgically removed.
Results: Ovarian tissue damage scores were significantly different among groups. Ovarian tissue and serum malondialdehyde levels in group III were significantly higher than those of groups I and IV (P < 0.05). The serum levels of superoxide dismutase in group III were significantly lower than those of groups I and IV (P = 0.01). Tissue and serum xanthine oxidase, nitric oxide, and tissue superoxide dismutase levels were comparable among groups (P > 0.05).
Conclusions: Aprotinin attenuates ischemia–reperfusion injury in a rat adnexial torsion–detorsion model.</description><subject>Animals</subject><subject>aprotinin</subject><subject>Aprotinin - pharmacology</subject><subject>Female</subject><subject>Hemostatics - pharmacology</subject><subject>Histocytochemistry</subject><subject>ischemia-reperfusion injury</subject><subject>ovary</subject><subject>Ovary - blood supply</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reperfusion Injury - blood</subject><subject>Reperfusion Injury - prevention & control</subject><subject>torsion</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFOwzAMhiMEYmPwCqgnbi1JkyaZxAUmKIyJcRhC4hK1aSoytnYk7djeHpdNcCVSZMv-P9v6EQoIjgi8y3lEGBMhFgmPYoxlBJ_xaHOA-r-NQ8gpI6HEgvfQifdzjIkYEnmMekRKyijlfTR-dnVjdGPXJjBlCVlQl0G2gqqtbBXUVWC9fjdLm4XOrIwrW2-7YjVv3RZC4DJA1pnbnqKjMlt4c7aPA_Rydzsb3YeTafowup6EmiWCh6zM8zimggwxybUsMlLQREtG-bAkmrCioJwSpgstSM605JQV0EgkSwrNYkoH6GI3F478bI1v1BJONItFVpm69YoPgY-xAKHcCbWrvXemVCtnl3CpIlh1Pqq56uxSnV2q81H9-Kg2gJ7vd7T50hR_4N44EFztBF92Ybb_HqzG0xQSwMMdbn1jNr945j4UF1Qk6vUpVW9pTMd49qhu6Dd_k5A2</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Sahin, Figen Kir</creator><creator>Cosar, Emine</creator><creator>Koken, Gulengul</creator><creator>Toy, Hatice</creator><creator>Basarali, Kemal</creator><creator>Buyukbas, Sadik</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>Protective effect of aprotinin on ischemia-reperfusion injury in rat ovary</title><author>Sahin, Figen Kir ; Cosar, Emine ; Koken, Gulengul ; Toy, Hatice ; Basarali, Kemal ; Buyukbas, Sadik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4576-4fbb22371901bc8da1d35c84369f1c14dd36314cdc71b4c8634df1c5845dc4233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>aprotinin</topic><topic>Aprotinin - pharmacology</topic><topic>Female</topic><topic>Hemostatics - pharmacology</topic><topic>Histocytochemistry</topic><topic>ischemia-reperfusion injury</topic><topic>ovary</topic><topic>Ovary - blood supply</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reperfusion Injury - blood</topic><topic>Reperfusion Injury - prevention & control</topic><topic>torsion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, Figen Kir</creatorcontrib><creatorcontrib>Cosar, Emine</creatorcontrib><creatorcontrib>Koken, Gulengul</creatorcontrib><creatorcontrib>Toy, Hatice</creatorcontrib><creatorcontrib>Basarali, Kemal</creatorcontrib><creatorcontrib>Buyukbas, Sadik</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahin, Figen Kir</au><au>Cosar, Emine</au><au>Koken, Gulengul</au><au>Toy, Hatice</au><au>Basarali, Kemal</au><au>Buyukbas, Sadik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of aprotinin on ischemia-reperfusion injury in rat ovary</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2008-10</date><risdate>2008</risdate><volume>34</volume><issue>5</issue><spage>794</spage><epage>800</epage><pages>794-800</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim: We investigated the effects of aprotinin on reperfusion injury in a controlled experimental rat torsion–detorsion model.
Methods: Thirty‐two female Sprague–Dawley rats were divided into four groups. Sham operation was performed in group I; in group II only ovarian torsion was performed. In group III, torsion–detorsion was performed, plus 3 mL/kg saline was injected i.v. 30 min before detorsion. In group IV, torsion–detorsion was performed, plus aprotinin (30 000 KIU/kg) was injected 30 min before detorsion. Rats in the torsion group were killed after 360° clockwise adnexial torsion for 3 h, and the ovaries were harvested. After 3 h of adnexial detorsion, the rats in the saline and aprotinin groups were killed and the adnexa were surgically removed.
Results: Ovarian tissue damage scores were significantly different among groups. Ovarian tissue and serum malondialdehyde levels in group III were significantly higher than those of groups I and IV (P < 0.05). The serum levels of superoxide dismutase in group III were significantly lower than those of groups I and IV (P = 0.01). Tissue and serum xanthine oxidase, nitric oxide, and tissue superoxide dismutase levels were comparable among groups (P > 0.05).
Conclusions: Aprotinin attenuates ischemia–reperfusion injury in a rat adnexial torsion–detorsion model.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>18834336</pmid><doi>10.1111/j.1447-0756.2008.00846.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1341-8076 |
| ispartof | The journal of obstetrics and gynaecology research, 2008-10, Vol.34 (5), p.794-800 |
| issn | 1341-8076 1447-0756 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69631207 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals aprotinin Aprotinin - pharmacology Female Hemostatics - pharmacology Histocytochemistry ischemia-reperfusion injury ovary Ovary - blood supply Rats Rats, Sprague-Dawley Reperfusion Injury - blood Reperfusion Injury - prevention & control torsion |
| title | Protective effect of aprotinin on ischemia-reperfusion injury in rat ovary |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T00%3A59%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effect%20of%20aprotinin%20on%20ischemia-reperfusion%20injury%20in%20rat%20ovary&rft.jtitle=The%20journal%20of%20obstetrics%20and%20gynaecology%20research&rft.au=Sahin,%20Figen%20Kir&rft.date=2008-10&rft.volume=34&rft.issue=5&rft.spage=794&rft.epage=800&rft.pages=794-800&rft.issn=1341-8076&rft.eissn=1447-0756&rft_id=info:doi/10.1111/j.1447-0756.2008.00846.x&rft_dat=%3Cproquest_cross%3E69631207%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69631207&rft_id=info:pmid/18834336&rfr_iscdi=true |