Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands

Research in the area of simutaneously targeting more than one G protein-coupled receptor (GPCR) has increased in recent times. By exploiting the cross talk between the beta2-adrenergic (beta2AR) and adenosine A1 receptors (A1AR) on adenylate cyclase activity, we synthesized a series of bivalent agon...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-10, Vol.51 (19), p.6128-6137
Hauptverfasser:	Karellas, Peter, McNaughton, Michael, Baker, Stephen P, Scammells, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A1 Receptor Agonists Adrenergic beta-2 Receptor Agonists Animals Binding Sites Carbamates - chemical synthesis Carbamates - chemistry Carbamates - pharmacology Cricetinae Crystallography, X-Ray Cyclic AMP - analysis Cyclic AMP - metabolism Dose-Response Relationship, Drug Formamides - chemical synthesis Formamides - chemistry Formamides - pharmacology Isoproterenol - pharmacology Ligands Models, Molecular Molecular Structure Stereoisomerism Structure-Activity Relationship Tumor Cells, Cultured
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