Correlation of MMP(1) and TIMP (1) expression with pituitary adenoma fibrosis
To explore the correlation of matrix metalloproteinase-1 (MMP(1)) and tissue inhibitor of metalloproteinase-1 (TIMP(1)) with pituitary adenoma fibrosis. Thirty-eight pituitary adenoma specimens were divided into fibrous group (6 patients) and non-fibrous group (32 patients). MMP(1) and TIMP(1) expre...
Gespeichert in:
| Veröffentlicht in: | Journal of neuro-oncology 2008-11, Vol.90 (2), p.151-156 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 156 |
|---|---|
| container_issue | 2 |
| container_start_page | 151 |
| container_title | Journal of neuro-oncology |
| container_volume | 90 |
| creator | Wang, Hui Li, Wen-Sheng Shi, De-Jin Ye, Zhuo-Peng Tai, Feng He, Hai-Yong Liang, Chao-Feng Gong, Jin Guo, Ying |
| description | To explore the correlation of matrix metalloproteinase-1 (MMP(1)) and tissue inhibitor of metalloproteinase-1 (TIMP(1)) with pituitary adenoma fibrosis.
Thirty-eight pituitary adenoma specimens were divided into fibrous group (6 patients) and non-fibrous group (32 patients). MMP(1) and TIMP(1) expression was detected by RT-PCR and immunohistochemistry. The collagen content was determined by Sirius scarlet staining.
In fibrous and non-fibrous group: (1) the collagen content was 20.95 +/- 8.42% and 7.98 +/- 5.18% respectively, and there was a statistical significance (P < 0.01). (2) The expression of MMP(1)mRNA was 0.47 +/- 0.40 and 0.59 +/- 0.54 respectively and its protein expression was 0.12 +/- 0.09 and 0.13 +/- 0.09 respectively, and there was no statistical significance (P > 0.05). Their expression was not related to collagen content (P > 0.05). (3) The expression of TIMP(1)mRNA was 1.61 +/- 1.09 and 0.79 +/- 0.59 respectively and its protein expression was 0.58 +/- 0.11 and 0.32 +/- 0.18 respectively, and there was a statistical significance (P < 0.01). Their expression was related to collagen content (P < 0.01).
The pathological features of pituitary adenoma fibrosis are excessive collagen deposition. High expression of TIMP(1) may be an important cause. |
| doi_str_mv | 10.1007/s11060-008-9647-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69629901</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69629901</sourcerecordid><originalsourceid>FETCH-LOGICAL-p544-d63cad0c636cc4d48764485cf4f65b09202faeeac82f22692cedf74f93f001cc3</originalsourceid><addsrcrecordid>eNo1jztPwzAYRT2AaCn8ABbkCcFg-Ow4djyiikelRnTowBa5fgijJA52IuDf0wqYrq50dHQvQhcUbimAvMuUggACUBEluCTqCM2BCklKxV9n6DTndwDgsqAnaEYrAZxLPkf1MqbkWj2G2OPocV1vrukN1r3F21W9wYfivobkcj4Qn2F8w0MYpzDq9I21dX3sNPZhl2IO-Qwde91md_6XC7R9fNgun8n65Wm1vF-ToeScWFEYbcGIQhjDLa-k4LwqjedelDtQDJjXzmlTMc-YUMw46yX3qvAA1Jhiga5-tUOKH5PLY9OFbFzb6t7FKTdCCaYU0D14-QdOu87ZZkih2-9u_v8XPz-CWi4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69629901</pqid></control><display><type>article</type><title>Correlation of MMP(1) and TIMP (1) expression with pituitary adenoma fibrosis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Wang, Hui ; Li, Wen-Sheng ; Shi, De-Jin ; Ye, Zhuo-Peng ; Tai, Feng ; He, Hai-Yong ; Liang, Chao-Feng ; Gong, Jin ; Guo, Ying</creator><creatorcontrib>Wang, Hui ; Li, Wen-Sheng ; Shi, De-Jin ; Ye, Zhuo-Peng ; Tai, Feng ; He, Hai-Yong ; Liang, Chao-Feng ; Gong, Jin ; Guo, Ying</creatorcontrib><description>To explore the correlation of matrix metalloproteinase-1 (MMP(1)) and tissue inhibitor of metalloproteinase-1 (TIMP(1)) with pituitary adenoma fibrosis.
Thirty-eight pituitary adenoma specimens were divided into fibrous group (6 patients) and non-fibrous group (32 patients). MMP(1) and TIMP(1) expression was detected by RT-PCR and immunohistochemistry. The collagen content was determined by Sirius scarlet staining.
In fibrous and non-fibrous group: (1) the collagen content was 20.95 +/- 8.42% and 7.98 +/- 5.18% respectively, and there was a statistical significance (P < 0.01). (2) The expression of MMP(1)mRNA was 0.47 +/- 0.40 and 0.59 +/- 0.54 respectively and its protein expression was 0.12 +/- 0.09 and 0.13 +/- 0.09 respectively, and there was no statistical significance (P > 0.05). Their expression was not related to collagen content (P > 0.05). (3) The expression of TIMP(1)mRNA was 1.61 +/- 1.09 and 0.79 +/- 0.59 respectively and its protein expression was 0.58 +/- 0.11 and 0.32 +/- 0.18 respectively, and there was a statistical significance (P < 0.01). Their expression was related to collagen content (P < 0.01).
The pathological features of pituitary adenoma fibrosis are excessive collagen deposition. High expression of TIMP(1) may be an important cause.</description><identifier>ISSN: 0167-594X</identifier><identifier>DOI: 10.1007/s11060-008-9647-9</identifier><identifier>PMID: 18604474</identifier><language>eng</language><publisher>United States</publisher><subject>Adenoma - metabolism ; Adenoma - pathology ; Adult ; Aged ; Collagen - metabolism ; Female ; Fibrosis ; Gene Expression ; Humans ; Male ; Matrix Metalloproteinase 1 - genetics ; Matrix Metalloproteinase 1 - metabolism ; Middle Aged ; Pituitary Neoplasms - metabolism ; Pituitary Neoplasms - pathology ; Retrospective Studies ; RNA, Messenger - metabolism ; Tissue Inhibitor of Metalloproteinase-1 - genetics ; Tissue Inhibitor of Metalloproteinase-1 - metabolism ; Young Adult</subject><ispartof>Journal of neuro-oncology, 2008-11, Vol.90 (2), p.151-156</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18604474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Li, Wen-Sheng</creatorcontrib><creatorcontrib>Shi, De-Jin</creatorcontrib><creatorcontrib>Ye, Zhuo-Peng</creatorcontrib><creatorcontrib>Tai, Feng</creatorcontrib><creatorcontrib>He, Hai-Yong</creatorcontrib><creatorcontrib>Liang, Chao-Feng</creatorcontrib><creatorcontrib>Gong, Jin</creatorcontrib><creatorcontrib>Guo, Ying</creatorcontrib><title>Correlation of MMP(1) and TIMP (1) expression with pituitary adenoma fibrosis</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><description>To explore the correlation of matrix metalloproteinase-1 (MMP(1)) and tissue inhibitor of metalloproteinase-1 (TIMP(1)) with pituitary adenoma fibrosis.
Thirty-eight pituitary adenoma specimens were divided into fibrous group (6 patients) and non-fibrous group (32 patients). MMP(1) and TIMP(1) expression was detected by RT-PCR and immunohistochemistry. The collagen content was determined by Sirius scarlet staining.
In fibrous and non-fibrous group: (1) the collagen content was 20.95 +/- 8.42% and 7.98 +/- 5.18% respectively, and there was a statistical significance (P < 0.01). (2) The expression of MMP(1)mRNA was 0.47 +/- 0.40 and 0.59 +/- 0.54 respectively and its protein expression was 0.12 +/- 0.09 and 0.13 +/- 0.09 respectively, and there was no statistical significance (P > 0.05). Their expression was not related to collagen content (P > 0.05). (3) The expression of TIMP(1)mRNA was 1.61 +/- 1.09 and 0.79 +/- 0.59 respectively and its protein expression was 0.58 +/- 0.11 and 0.32 +/- 0.18 respectively, and there was a statistical significance (P < 0.01). Their expression was related to collagen content (P < 0.01).
The pathological features of pituitary adenoma fibrosis are excessive collagen deposition. High expression of TIMP(1) may be an important cause.</description><subject>Adenoma - metabolism</subject><subject>Adenoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Collagen - metabolism</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase 1 - genetics</subject><subject>Matrix Metalloproteinase 1 - metabolism</subject><subject>Middle Aged</subject><subject>Pituitary Neoplasms - metabolism</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Retrospective Studies</subject><subject>RNA, Messenger - metabolism</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - genetics</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - metabolism</subject><subject>Young Adult</subject><issn>0167-594X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1jztPwzAYRT2AaCn8ABbkCcFg-Ow4djyiikelRnTowBa5fgijJA52IuDf0wqYrq50dHQvQhcUbimAvMuUggACUBEluCTqCM2BCklKxV9n6DTndwDgsqAnaEYrAZxLPkf1MqbkWj2G2OPocV1vrukN1r3F21W9wYfivobkcj4Qn2F8w0MYpzDq9I21dX3sNPZhl2IO-Qwde91md_6XC7R9fNgun8n65Wm1vF-ToeScWFEYbcGIQhjDLa-k4LwqjedelDtQDJjXzmlTMc-YUMw46yX3qvAA1Jhiga5-tUOKH5PLY9OFbFzb6t7FKTdCCaYU0D14-QdOu87ZZkih2-9u_v8XPz-CWi4</recordid><startdate>200811</startdate><enddate>200811</enddate><creator>Wang, Hui</creator><creator>Li, Wen-Sheng</creator><creator>Shi, De-Jin</creator><creator>Ye, Zhuo-Peng</creator><creator>Tai, Feng</creator><creator>He, Hai-Yong</creator><creator>Liang, Chao-Feng</creator><creator>Gong, Jin</creator><creator>Guo, Ying</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200811</creationdate><title>Correlation of MMP(1) and TIMP (1) expression with pituitary adenoma fibrosis</title><author>Wang, Hui ; Li, Wen-Sheng ; Shi, De-Jin ; Ye, Zhuo-Peng ; Tai, Feng ; He, Hai-Yong ; Liang, Chao-Feng ; Gong, Jin ; Guo, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p544-d63cad0c636cc4d48764485cf4f65b09202faeeac82f22692cedf74f93f001cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenoma - metabolism</topic><topic>Adenoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Collagen - metabolism</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinase 1 - genetics</topic><topic>Matrix Metalloproteinase 1 - metabolism</topic><topic>Middle Aged</topic><topic>Pituitary Neoplasms - metabolism</topic><topic>Pituitary Neoplasms - pathology</topic><topic>Retrospective Studies</topic><topic>RNA, Messenger - metabolism</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - genetics</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Li, Wen-Sheng</creatorcontrib><creatorcontrib>Shi, De-Jin</creatorcontrib><creatorcontrib>Ye, Zhuo-Peng</creatorcontrib><creatorcontrib>Tai, Feng</creatorcontrib><creatorcontrib>He, Hai-Yong</creatorcontrib><creatorcontrib>Liang, Chao-Feng</creatorcontrib><creatorcontrib>Gong, Jin</creatorcontrib><creatorcontrib>Guo, Ying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Hui</au><au>Li, Wen-Sheng</au><au>Shi, De-Jin</au><au>Ye, Zhuo-Peng</au><au>Tai, Feng</au><au>He, Hai-Yong</au><au>Liang, Chao-Feng</au><au>Gong, Jin</au><au>Guo, Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of MMP(1) and TIMP (1) expression with pituitary adenoma fibrosis</atitle><jtitle>Journal of neuro-oncology</jtitle><addtitle>J Neurooncol</addtitle><date>2008-11</date><risdate>2008</risdate><volume>90</volume><issue>2</issue><spage>151</spage><epage>156</epage><pages>151-156</pages><issn>0167-594X</issn><abstract>To explore the correlation of matrix metalloproteinase-1 (MMP(1)) and tissue inhibitor of metalloproteinase-1 (TIMP(1)) with pituitary adenoma fibrosis.
Thirty-eight pituitary adenoma specimens were divided into fibrous group (6 patients) and non-fibrous group (32 patients). MMP(1) and TIMP(1) expression was detected by RT-PCR and immunohistochemistry. The collagen content was determined by Sirius scarlet staining.
In fibrous and non-fibrous group: (1) the collagen content was 20.95 +/- 8.42% and 7.98 +/- 5.18% respectively, and there was a statistical significance (P < 0.01). (2) The expression of MMP(1)mRNA was 0.47 +/- 0.40 and 0.59 +/- 0.54 respectively and its protein expression was 0.12 +/- 0.09 and 0.13 +/- 0.09 respectively, and there was no statistical significance (P > 0.05). Their expression was not related to collagen content (P > 0.05). (3) The expression of TIMP(1)mRNA was 1.61 +/- 1.09 and 0.79 +/- 0.59 respectively and its protein expression was 0.58 +/- 0.11 and 0.32 +/- 0.18 respectively, and there was a statistical significance (P < 0.01). Their expression was related to collagen content (P < 0.01).
The pathological features of pituitary adenoma fibrosis are excessive collagen deposition. High expression of TIMP(1) may be an important cause.</abstract><cop>United States</cop><pmid>18604474</pmid><doi>10.1007/s11060-008-9647-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-594X |
| ispartof | Journal of neuro-oncology, 2008-11, Vol.90 (2), p.151-156 |
| issn | 0167-594X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69629901 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adenoma - metabolism Adenoma - pathology Adult Aged Collagen - metabolism Female Fibrosis Gene Expression Humans Male Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Middle Aged Pituitary Neoplasms - metabolism Pituitary Neoplasms - pathology Retrospective Studies RNA, Messenger - metabolism Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - metabolism Young Adult |
| title | Correlation of MMP(1) and TIMP (1) expression with pituitary adenoma fibrosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T22%3A54%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20of%20MMP(1)%20and%20TIMP%20(1)%20expression%20with%20pituitary%20adenoma%20fibrosis&rft.jtitle=Journal%20of%20neuro-oncology&rft.au=Wang,%20Hui&rft.date=2008-11&rft.volume=90&rft.issue=2&rft.spage=151&rft.epage=156&rft.pages=151-156&rft.issn=0167-594X&rft_id=info:doi/10.1007/s11060-008-9647-9&rft_dat=%3Cproquest_pubme%3E69629901%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69629901&rft_id=info:pmid/18604474&rfr_iscdi=true |