Involvement of cPLA2 Inhibition in Dexamethasone-Induced Thymocyte Apoptosis

Various molecular mechanisms have been suggested to be involved in dexamethasone induced thymocyte apoptosis. In this study we show that pharmacological inhibition of cytoplasmic PLA2 in mouse thymocytes for 18 h with arachidonyl trifluoromethyl ketone (AACOCF3) (10 μM) and palmitoyl trifluoromethyl...

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Veröffentlicht in:	International journal of immunopathology and pharmacology 2008-07, Vol.21 (3), p.539-551
Hauptverfasser:	Cinque, B., Fanini, D., Di Marzio, L., Palumbo, P., La Torre, C., Donato, V., Velardi, E., Bruscoli, S., Riccardi, C., Cifone, M.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Arachidonic Acid - secretion Arachidonic Acids - pharmacology Caspase 3 - metabolism Ceramides - metabolism Cytoplasm - enzymology Dexamethasone - pharmacology Male Mice Mice, Inbred C3H Mifepristone - pharmacology Phosphoinositide Phospholipase C - metabolism Phospholipase A2 Inhibitors Phospholipases A2 - physiology T-Lymphocytes - drug effects
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