Identification of TAXREB107 as an erythropoietin early response gene
The protooncogenes c-myc and c-myb are erythropoietin (Epo)-regulated early response genes. They appear to play distinct roles in the growth- and differentiation-inducing signals of the hormone. Using a subtractive hybridization strategy, we have identified the murine homolog of the TAX response ele...
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| Veröffentlicht in: | AIDS research and human retroviruses 1999-03, Vol.15 (4), p.375-379 |
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| container_title | AIDS research and human retroviruses |
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| creator | RIXIN LI MADDEN, H SYTKOWSKI, A. J |
| description | The protooncogenes c-myc and c-myb are erythropoietin (Epo)-regulated early response genes. They appear to play distinct roles in the growth- and differentiation-inducing signals of the hormone. Using a subtractive hybridization strategy, we have identified the murine homolog of the TAX response element-binding protein TAXREB107 as an Epo early response gene in Rauscher murine erythroleukemia cells. This was confirmed by Northern blot analyses, which showed a fourfold increase in TAXREB107 mRNA after 1 hr of erythropoietin treatment. After 3 hr the transcript had decreased to approximately twofold above control levels. Inhibition of this induction with antisense oligodeoxynucleotides increased Epo-induced hemoglobinization 2.5-fold. The results implicate TAXREB107 in erythropoiesis and support the hypothesis that the TAXREB proteins have functions outside the context of HTLV-I infection. |
| doi_str_mv | 10.1089/088922299311349 |
| format | Article |
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The results implicate TAXREB107 in erythropoiesis and support the hypothesis that the TAXREB proteins have functions outside the context of HTLV-I infection.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/088922299311349</identifier><identifier>PMID: 10082121</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS/HIV ; Animals ; Biological and medical sciences ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; DNA-Binding Proteins - genetics ; Erythropoietin - metabolism ; Erythropoietin - pharmacology ; Fundamental and applied biological sciences. 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The results implicate TAXREB107 in erythropoiesis and support the hypothesis that the TAXREB proteins have functions outside the context of HTLV-I infection.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Erythropoietin - metabolism</subject><subject>Erythropoietin - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human T-lymphotropic virus 1</subject><subject>Humans</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Tumor Cells, Cultured</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9LwzAUB_AgipvTszfpQbzVvfxomhznnDoYCDLBW0nTF610zUy6w_57OzZQvHjKC-_zHrwvIZcUbikoPQalNGNMa04pF_qIDGlfpkpAdkyGu266aw_IWYyfANDj7JQMKIBilNEhuZ9X2Ha1q63pat8m3iXLydvL7I5CnpiYmDbBsO0-gl_7Gru6_5rQbJOAce3biMk7tnhOTpxpIl4c3hF5fZgtp0_p4vlxPp0sUssz3qUCXFlVpc2gykpLmdJCcCfzUmGueM5lyUG4EsEoQKggd04oSXUmKVUWGR-Rm_3edfBfG4xdsaqjxaYxLfpNLKSWTFGl_4U0Z1wwJns43kMbfIwBXbEO9cqEbUGh2CVc_Em4n7g6rN6UK6x--X2kPbg-ABOtaVwwra3jj8ulEv25322CgIQ</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>RIXIN LI</creator><creator>MADDEN, H</creator><creator>SYTKOWSKI, A. 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Psychology</topic><topic>Human T-lymphotropic virus 1</topic><topic>Humans</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIXIN LI</creatorcontrib><creatorcontrib>MADDEN, H</creatorcontrib><creatorcontrib>SYTKOWSKI, A. 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This was confirmed by Northern blot analyses, which showed a fourfold increase in TAXREB107 mRNA after 1 hr of erythropoietin treatment. After 3 hr the transcript had decreased to approximately twofold above control levels. Inhibition of this induction with antisense oligodeoxynucleotides increased Epo-induced hemoglobinization 2.5-fold. The results implicate TAXREB107 in erythropoiesis and support the hypothesis that the TAXREB proteins have functions outside the context of HTLV-I infection.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>10082121</pmid><doi>10.1089/088922299311349</doi><tpages>5</tpages></addata></record> |
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| ispartof | AIDS research and human retroviruses, 1999-03, Vol.15 (4), p.375-379 |
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| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology DNA-Binding Proteins - genetics Erythropoietin - metabolism Erythropoietin - pharmacology Fundamental and applied biological sciences. Psychology Human T-lymphotropic virus 1 Humans Mice Molecular and cellular biology Tumor Cells, Cultured |
| title | Identification of TAXREB107 as an erythropoietin early response gene |
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