GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by 2 genes, GSK3A and GSK3B. GSK-3 is thought to be involved in tissue repair and fibrogenesis, but its role in these processes is currently unknown. To investigate the function of G...

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Veröffentlicht in:	The Journal of clinical investigation 2008-10, Vol.118 (10), p.3279-3290
Hauptverfasser:	Kapoor, Mohit, Liu, Shangxi, Shi-wen, Xu, Huh, Kun, McCann, Matthew, Denton, Christopher P, Woodgett, James R, Abraham, David J, Leask, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics beta Catenin - metabolism Cell Line Cicatrix - genetics Collagen - biosynthesis Endothelin A Receptor Antagonists Endothelin B Receptor Antagonists Endothelin-1 - genetics Endothelin-1 - metabolism Female Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - physiology Fibrosis - metabolism Gene Expression Regulation Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Male Mice Mice, Inbred C57BL Mice, Knockout Receptor, Endothelin A - metabolism Receptor, Endothelin B - metabolism Sequence Deletion Signal Transduction Sulfonamides - pharmacology Time Factors Wound Healing - drug effects Wound Healing - physiology
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