Tolerance without Clonal Expansion: Self-Antigen-Expressing B Cells Program Self-Reactive T Cells for Future Deletion

B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecul...

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Veröffentlicht in:The Journal of immunology (1950) 2008-10, Vol.181 (8), p.5748-5759
Hauptverfasser: Frommer, Friederike, Heinen, Tobias J. A. J, Wunderlich, F. Thomas, Yogev, Nir, Buch, Thorsten, Roers, Axel, Bettelli, Estelle, Muller, Werner, Anderton, Stephen M, Waisman, Ari
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