Tolerance without Clonal Expansion: Self-Antigen-Expressing B Cells Program Self-Reactive T Cells for Future Deletion
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecul...
Gespeichert in:
| Veröffentlicht in: | The Journal of immunology (1950) 2008-10, Vol.181 (8), p.5748-5759 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5759 |
|---|---|
| container_issue | 8 |
| container_start_page | 5748 |
| container_title | The Journal of immunology (1950) |
| container_volume | 181 |
| creator | Frommer, Friederike Heinen, Tobias J. A. J Wunderlich, F. Thomas Yogev, Nir Buch, Thorsten Roers, Axel Bettelli, Estelle Muller, Werner Anderton, Stephen M Waisman, Ari |
| description | B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecules such as PD-1, CTLA-4, B and T lymphocyte attenuator, and CD5. Following interaction with B cells, T cells were not induced to proliferate, in a process that was dependent on their expression of PD-1 and CTLA-4, but not CD5. In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells. |
| doi_str_mv | 10.4049/jimmunol.181.8.5748 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69627556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69627556</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-71a6d5ce0b24cba7af1daff1381932df97006ec359d39a073dfd1de489621843</originalsourceid><addsrcrecordid>eNpNkE1P3DAQhi3UCpaPX4CEfGpP2dpxYjvc6JaPSkitYO-WNxnvGjn2YidN-fcY7SI4jTTzzKuZB6FzSuYVqZofT7bvRx_cnEo6l_NaVPIAzWhdk4Jzwr-gGSFlWVDBxRE6TumJEMJJWR2iIyolKwWrZmhcBgdR-xbwZIdNGAe8cMFrh6__b7VPNvhL_AjOFFd-sGvwRe5HSMn6Nf6JF-Bcwn9jWEfd77gH0O1g_wFe7qcmRHwzDmME_AscDDnyFH012iU429cTtLy5Xi7uivs_t78XV_dFyyQZCkE17-oWyKqs2pUW2tBOG0OZpA0rO9OI_BG0rG461mgiWGc62kElG15SWbET9G0Xu43heYQ0qN6mNh-lPYQxKZ45Udc8g2wHtjGkFMGobbS9ji-KEvUmW73LVlm2kupNdt662MePqx66j5293Qx83wEbu95MNoJKvXYu41RN0_Qp6hVYW4we</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69627556</pqid></control><display><type>article</type><title>Tolerance without Clonal Expansion: Self-Antigen-Expressing B Cells Program Self-Reactive T Cells for Future Deletion</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Frommer, Friederike ; Heinen, Tobias J. A. J ; Wunderlich, F. Thomas ; Yogev, Nir ; Buch, Thorsten ; Roers, Axel ; Bettelli, Estelle ; Muller, Werner ; Anderton, Stephen M ; Waisman, Ari</creator><creatorcontrib>Frommer, Friederike ; Heinen, Tobias J. A. J ; Wunderlich, F. Thomas ; Yogev, Nir ; Buch, Thorsten ; Roers, Axel ; Bettelli, Estelle ; Muller, Werner ; Anderton, Stephen M ; Waisman, Ari</creatorcontrib><description>B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecules such as PD-1, CTLA-4, B and T lymphocyte attenuator, and CD5. Following interaction with B cells, T cells were not induced to proliferate, in a process that was dependent on their expression of PD-1 and CTLA-4, but not CD5. In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.181.8.5748</identifier><identifier>PMID: 18832734</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Animals ; Antigens, CD - biosynthesis ; Antigens, CD - genetics ; Antigens, CD - immunology ; Antigens, Differentiation - biosynthesis ; Antigens, Differentiation - genetics ; Antigens, Differentiation - immunology ; Autoantigens - biosynthesis ; Autoantigens - immunology ; Autoimmunity - physiology ; B-Lymphocytes - immunology ; B-Lymphocytes - metabolism ; CD5 Antigens - biosynthesis ; CD5 Antigens - genetics ; CD5 Antigens - immunology ; Cell Proliferation ; Clonal Deletion - physiology ; CTLA-4 Antigen ; Gene Expression Regulation - immunology ; Homeostasis - immunology ; Mice ; Mice, Transgenic ; Programmed Cell Death 1 Receptor ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism</subject><ispartof>The Journal of immunology (1950), 2008-10, Vol.181 (8), p.5748-5759</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-71a6d5ce0b24cba7af1daff1381932df97006ec359d39a073dfd1de489621843</citedby><cites>FETCH-LOGICAL-c380t-71a6d5ce0b24cba7af1daff1381932df97006ec359d39a073dfd1de489621843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18832734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frommer, Friederike</creatorcontrib><creatorcontrib>Heinen, Tobias J. A. J</creatorcontrib><creatorcontrib>Wunderlich, F. Thomas</creatorcontrib><creatorcontrib>Yogev, Nir</creatorcontrib><creatorcontrib>Buch, Thorsten</creatorcontrib><creatorcontrib>Roers, Axel</creatorcontrib><creatorcontrib>Bettelli, Estelle</creatorcontrib><creatorcontrib>Muller, Werner</creatorcontrib><creatorcontrib>Anderton, Stephen M</creatorcontrib><creatorcontrib>Waisman, Ari</creatorcontrib><title>Tolerance without Clonal Expansion: Self-Antigen-Expressing B Cells Program Self-Reactive T Cells for Future Deletion</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecules such as PD-1, CTLA-4, B and T lymphocyte attenuator, and CD5. Following interaction with B cells, T cells were not induced to proliferate, in a process that was dependent on their expression of PD-1 and CTLA-4, but not CD5. In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells.</description><subject>Animals</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, Differentiation - biosynthesis</subject><subject>Antigens, Differentiation - genetics</subject><subject>Antigens, Differentiation - immunology</subject><subject>Autoantigens - biosynthesis</subject><subject>Autoantigens - immunology</subject><subject>Autoimmunity - physiology</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - metabolism</subject><subject>CD5 Antigens - biosynthesis</subject><subject>CD5 Antigens - genetics</subject><subject>CD5 Antigens - immunology</subject><subject>Cell Proliferation</subject><subject>Clonal Deletion - physiology</subject><subject>CTLA-4 Antigen</subject><subject>Gene Expression Regulation - immunology</subject><subject>Homeostasis - immunology</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Programmed Cell Death 1 Receptor</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1P3DAQhi3UCpaPX4CEfGpP2dpxYjvc6JaPSkitYO-WNxnvGjn2YidN-fcY7SI4jTTzzKuZB6FzSuYVqZofT7bvRx_cnEo6l_NaVPIAzWhdk4Jzwr-gGSFlWVDBxRE6TumJEMJJWR2iIyolKwWrZmhcBgdR-xbwZIdNGAe8cMFrh6__b7VPNvhL_AjOFFd-sGvwRe5HSMn6Nf6JF-Bcwn9jWEfd77gH0O1g_wFe7qcmRHwzDmME_AscDDnyFH012iU429cTtLy5Xi7uivs_t78XV_dFyyQZCkE17-oWyKqs2pUW2tBOG0OZpA0rO9OI_BG0rG461mgiWGc62kElG15SWbET9G0Xu43heYQ0qN6mNh-lPYQxKZ45Udc8g2wHtjGkFMGobbS9ji-KEvUmW73LVlm2kupNdt662MePqx66j5293Qx83wEbu95MNoJKvXYu41RN0_Qp6hVYW4we</recordid><startdate>20081015</startdate><enddate>20081015</enddate><creator>Frommer, Friederike</creator><creator>Heinen, Tobias J. A. J</creator><creator>Wunderlich, F. Thomas</creator><creator>Yogev, Nir</creator><creator>Buch, Thorsten</creator><creator>Roers, Axel</creator><creator>Bettelli, Estelle</creator><creator>Muller, Werner</creator><creator>Anderton, Stephen M</creator><creator>Waisman, Ari</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081015</creationdate><title>Tolerance without Clonal Expansion: Self-Antigen-Expressing B Cells Program Self-Reactive T Cells for Future Deletion</title><author>Frommer, Friederike ; Heinen, Tobias J. A. J ; Wunderlich, F. Thomas ; Yogev, Nir ; Buch, Thorsten ; Roers, Axel ; Bettelli, Estelle ; Muller, Werner ; Anderton, Stephen M ; Waisman, Ari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-71a6d5ce0b24cba7af1daff1381932df97006ec359d39a073dfd1de489621843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, Differentiation - biosynthesis</topic><topic>Antigens, Differentiation - genetics</topic><topic>Antigens, Differentiation - immunology</topic><topic>Autoantigens - biosynthesis</topic><topic>Autoantigens - immunology</topic><topic>Autoimmunity - physiology</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - metabolism</topic><topic>CD5 Antigens - biosynthesis</topic><topic>CD5 Antigens - genetics</topic><topic>CD5 Antigens - immunology</topic><topic>Cell Proliferation</topic><topic>Clonal Deletion - physiology</topic><topic>CTLA-4 Antigen</topic><topic>Gene Expression Regulation - immunology</topic><topic>Homeostasis - immunology</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Programmed Cell Death 1 Receptor</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frommer, Friederike</creatorcontrib><creatorcontrib>Heinen, Tobias J. A. J</creatorcontrib><creatorcontrib>Wunderlich, F. Thomas</creatorcontrib><creatorcontrib>Yogev, Nir</creatorcontrib><creatorcontrib>Buch, Thorsten</creatorcontrib><creatorcontrib>Roers, Axel</creatorcontrib><creatorcontrib>Bettelli, Estelle</creatorcontrib><creatorcontrib>Muller, Werner</creatorcontrib><creatorcontrib>Anderton, Stephen M</creatorcontrib><creatorcontrib>Waisman, Ari</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frommer, Friederike</au><au>Heinen, Tobias J. A. J</au><au>Wunderlich, F. Thomas</au><au>Yogev, Nir</au><au>Buch, Thorsten</au><au>Roers, Axel</au><au>Bettelli, Estelle</au><au>Muller, Werner</au><au>Anderton, Stephen M</au><au>Waisman, Ari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tolerance without Clonal Expansion: Self-Antigen-Expressing B Cells Program Self-Reactive T Cells for Future Deletion</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2008-10-15</date><risdate>2008</risdate><volume>181</volume><issue>8</issue><spage>5748</spage><epage>5759</epage><pages>5748-5759</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecules such as PD-1, CTLA-4, B and T lymphocyte attenuator, and CD5. Following interaction with B cells, T cells were not induced to proliferate, in a process that was dependent on their expression of PD-1 and CTLA-4, but not CD5. In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>18832734</pmid><doi>10.4049/jimmunol.181.8.5748</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 2008-10, Vol.181 (8), p.5748-5759 |
| issn | 0022-1767 1550-6606 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69627556 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antigens, CD - biosynthesis Antigens, CD - genetics Antigens, CD - immunology Antigens, Differentiation - biosynthesis Antigens, Differentiation - genetics Antigens, Differentiation - immunology Autoantigens - biosynthesis Autoantigens - immunology Autoimmunity - physiology B-Lymphocytes - immunology B-Lymphocytes - metabolism CD5 Antigens - biosynthesis CD5 Antigens - genetics CD5 Antigens - immunology Cell Proliferation Clonal Deletion - physiology CTLA-4 Antigen Gene Expression Regulation - immunology Homeostasis - immunology Mice Mice, Transgenic Programmed Cell Death 1 Receptor T-Lymphocytes - immunology T-Lymphocytes - metabolism |
| title | Tolerance without Clonal Expansion: Self-Antigen-Expressing B Cells Program Self-Reactive T Cells for Future Deletion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A24%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tolerance%20without%20Clonal%20Expansion:%20Self-Antigen-Expressing%20B%20Cells%20Program%20Self-Reactive%20T%20Cells%20for%20Future%20Deletion&rft.jtitle=The%20Journal%20of%20immunology%20(1950)&rft.au=Frommer,%20Friederike&rft.date=2008-10-15&rft.volume=181&rft.issue=8&rft.spage=5748&rft.epage=5759&rft.pages=5748-5759&rft.issn=0022-1767&rft.eissn=1550-6606&rft_id=info:doi/10.4049/jimmunol.181.8.5748&rft_dat=%3Cproquest_cross%3E69627556%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69627556&rft_id=info:pmid/18832734&rfr_iscdi=true |