Convergent synthesis, chiral HPLC, and vitamin D receptor affinity of analogs of 1,25-dihydroxycholecalciferol

A series of analogs of 1,25‐dihydroxycholecalciferol was obtained with an additional chiral center at the terminus of the aliphatic side chain (C‐25). The analogs were obtained from (+)‐(R)‐ and (−)‐(S)‐2‐methylglycidols, by opening of the oxirane ring with the carbanions derived from vitamin D C23a...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 1999, Vol.11 (3), p.249-255
Hauptverfasser:	Odrzywolska, Małgorzata, Chodyński, Michał, Halkes, Sebastian J., Van De Velde, Jan-Paul, Fitak, Hanna, Kutner, Andrzej
Format:	Artikel
Sprache:	eng
Schlagworte:	(+)-(R)-2-methylglycidol (−)-(S)-2-methylglycidol Animals Calcitriol - analogs & derivatives Calcitriol - chemical synthesis Calcitriol - metabolism Cattle chiral stationary phase HPLC Chromatography, High Pressure Liquid convergent synthesis Protein Binding Radioligand Assay Receptors, Calcitriol - metabolism Stereoisomerism vitamin D synthons
Online-Zugang:	Volltext
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