Duplex Recognition by Oligonucleotides Containing 2‘-Deoxy-2‘-fluoro-d-arabinose and 2‘-Deoxy-2‘-fluoro-d-ribose. Intermolecular 2‘-OH−Phosphate Contacts versus Sugar Puckering in the Stabilization of Triple-Helical Complexes

To gain insight into the origins of the large binding affinity of RNA toward target duplexes, 2‘-deoxy-2‘-fluororibonucleic acid (2‘F-RNA) and 2‘-deoxy-2‘-fluoroarabinonucleic acid (2‘F-ANA) were tested for their ability to recognize duplex DNA, duplex RNA, and RNA−DNA hybrids. 2‘F-RNA, 2‘F-ANA, and...

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Veröffentlicht in:	Bioconjugate chemistry 1999-03, Vol.10 (2), p.299-305
Hauptverfasser:	Wilds, Christopher James, Damha, Masad José
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabinose - analogs & derivatives Base Sequence Deoxyribose - analogs & derivatives DNA - chemistry Drug Stability Models, Molecular Molecular Structure Nucleic Acid Conformation Nucleic Acid Hybridization Oligodeoxyribonucleotides - chemical synthesis Oligodeoxyribonucleotides - chemistry RNA - chemistry
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