A Cluster of Transfusion-Associated Babesiosis Cases Traced to a Single Asymptomatic Donor
CONTEXT The risk of acquiring babesiosis by blood transfusion is largely unknown since in areas where it is endemic it is often an asymptomatic infection. OBJECTIVE To investigate and treat a cluster of blood transfusion–associated babesiosis cases. DESIGN Case series and epidemiologic investigation...
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| Veröffentlicht in: | JAMA : the journal of the American Medical Association 1999-03, Vol.281 (10), p.927-930 |
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| container_title | JAMA : the journal of the American Medical Association |
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| creator | Dobroszycki, Joanna Herwaldt, Barbara L Boctor, Fouad Miller, James R Linden, Jeanne Eberhard, Mark L Yoon, Jing Ja Ali, Nahed M Tanowitz, Herbert B Graham, Fitzroy Weiss, Louis M Wittner, Murray |
| description | CONTEXT The risk of acquiring babesiosis by blood transfusion
is largely unknown since in areas where it is endemic it is often an
asymptomatic infection. OBJECTIVE To investigate and treat a cluster of blood
transfusion–associated babesiosis cases. DESIGN Case series and epidemiologic investigation. SETTING Urban inner-city hospital. PATIENTS Six persons who received Babesia
microti–infected blood components from a donor. MAIN OUTCOME MEASURE Diagnosis and successful therapy of
babesiosis following transfusion. RESULTS Six individuals (1 adult, 1 child, and 4 neonates) were
exposed to products from a single blood donation by an asymptomatic
Babesia-infected donor. Three of the 6 exposed patients became
parasitemic. Polymerase chain reaction testing, animal inoculation
studies, and indirect immunofluorescent antibody testing were used to
confirm the presence of Babesia microti in the donor's blood
and to establish the presence of infection in 3 of the 6 recipients.
The 3 infected recipients and 1 additional recipient were treated
without incident. CONCLUSION Physicians should consider babesiosis in the
differential diagnosis of a febrile hemolytic disorder after blood
transfusion. Prompt diagnosis is important since babesiosis is
responsive to antibiotic therapy and, untreated, can be a fatal disease
in certain risk groups. |
| doi_str_mv | 10.1001/jama.281.10.927 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69625378</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>189030</ama_id><sourcerecordid>17237008</sourcerecordid><originalsourceid>FETCH-LOGICAL-a494t-251a6f31d9cbb701466b316671e77b72ff0a987b0cdb7619ded64c68d80de2bd3</originalsourceid><addsrcrecordid>eNqF0Utr3DAQAGARWrKbtOeSSxGh5OatRrL1OG62SRoI5ND00ovRy8GLbW099mH_fRSyZaGX6CJm9M3AjAj5AmwFjMH3re3timvI0cpwdUKWUAldiMroD2TJmNGFKnW5IGeIW5YPCHVKFrlW6dKwJfmzpptuximONDX0abQDNjO2aSjWiMm3doqBXlsXcw5bpBuLEV-dz_kpUUt_tcNzF-ka9_1uSr2dWk9_pCGNn8jHxnYYPx_uc_L79uZp87N4eLy736wfCluacip4BVY2AoLxzikGpZROgJQKolJO8aZh1mjlmA9OSTAhBll6qYNmIXIXxDm5euu7G9PfOeJU9y362HV2iGnGWhrJK6H0uxAUF4qxV3j5H9ymeRzyEDUHEMJwaTL6ekCz62Ood2Pb23Ff_9ttBt8OwKK3XZN361s8OgUcKp7ZxRvLX3l81LkBEy9t1I9Z</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211339269</pqid></control><display><type>article</type><title>A Cluster of Transfusion-Associated Babesiosis Cases Traced to a Single Asymptomatic Donor</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>Dobroszycki, Joanna ; Herwaldt, Barbara L ; Boctor, Fouad ; Miller, James R ; Linden, Jeanne ; Eberhard, Mark L ; Yoon, Jing Ja ; Ali, Nahed M ; Tanowitz, Herbert B ; Graham, Fitzroy ; Weiss, Louis M ; Wittner, Murray</creator><creatorcontrib>Dobroszycki, Joanna ; Herwaldt, Barbara L ; Boctor, Fouad ; Miller, James R ; Linden, Jeanne ; Eberhard, Mark L ; Yoon, Jing Ja ; Ali, Nahed M ; Tanowitz, Herbert B ; Graham, Fitzroy ; Weiss, Louis M ; Wittner, Murray</creatorcontrib><description>CONTEXT The risk of acquiring babesiosis by blood transfusion
is largely unknown since in areas where it is endemic it is often an
asymptomatic infection. OBJECTIVE To investigate and treat a cluster of blood
transfusion–associated babesiosis cases. DESIGN Case series and epidemiologic investigation. SETTING Urban inner-city hospital. PATIENTS Six persons who received Babesia
microti–infected blood components from a donor. MAIN OUTCOME MEASURE Diagnosis and successful therapy of
babesiosis following transfusion. RESULTS Six individuals (1 adult, 1 child, and 4 neonates) were
exposed to products from a single blood donation by an asymptomatic
Babesia-infected donor. Three of the 6 exposed patients became
parasitemic. Polymerase chain reaction testing, animal inoculation
studies, and indirect immunofluorescent antibody testing were used to
confirm the presence of Babesia microti in the donor's blood
and to establish the presence of infection in 3 of the 6 recipients.
The 3 infected recipients and 1 additional recipient were treated
without incident. CONCLUSION Physicians should consider babesiosis in the
differential diagnosis of a febrile hemolytic disorder after blood
transfusion. Prompt diagnosis is important since babesiosis is
responsive to antibiotic therapy and, untreated, can be a fatal disease
in certain risk groups.</description><identifier>ISSN: 0098-7484</identifier><identifier>EISSN: 1538-3598</identifier><identifier>DOI: 10.1001/jama.281.10.927</identifier><identifier>PMID: 10078490</identifier><identifier>CODEN: JAMAAP</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Babesia - isolation & purification ; Babesia microti ; Babesiosis - diagnosis ; Babesiosis - epidemiology ; Babesiosis - transmission ; Biological and medical sciences ; Blood Donors ; Blood transfusions ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Child ; Cluster Analysis ; Contact Tracing ; Disease ; Humans ; Infant, Newborn ; Medical sciences ; Parasitemia - diagnosis ; Parasitemia - transmission ; Transfusion Reaction ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>JAMA : the journal of the American Medical Association, 1999-03, Vol.281 (10), p.927-930</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Medical Association Mar 10, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a494t-251a6f31d9cbb701466b316671e77b72ff0a987b0cdb7619ded64c68d80de2bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jama/articlepdf/10.1001/jama.281.10.927$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.281.10.927$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,776,780,3327,27901,27902,76232,76235</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1712152$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10078490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dobroszycki, Joanna</creatorcontrib><creatorcontrib>Herwaldt, Barbara L</creatorcontrib><creatorcontrib>Boctor, Fouad</creatorcontrib><creatorcontrib>Miller, James R</creatorcontrib><creatorcontrib>Linden, Jeanne</creatorcontrib><creatorcontrib>Eberhard, Mark L</creatorcontrib><creatorcontrib>Yoon, Jing Ja</creatorcontrib><creatorcontrib>Ali, Nahed M</creatorcontrib><creatorcontrib>Tanowitz, Herbert B</creatorcontrib><creatorcontrib>Graham, Fitzroy</creatorcontrib><creatorcontrib>Weiss, Louis M</creatorcontrib><creatorcontrib>Wittner, Murray</creatorcontrib><title>A Cluster of Transfusion-Associated Babesiosis Cases Traced to a Single Asymptomatic Donor</title><title>JAMA : the journal of the American Medical Association</title><addtitle>JAMA</addtitle><description>CONTEXT The risk of acquiring babesiosis by blood transfusion
is largely unknown since in areas where it is endemic it is often an
asymptomatic infection. OBJECTIVE To investigate and treat a cluster of blood
transfusion–associated babesiosis cases. DESIGN Case series and epidemiologic investigation. SETTING Urban inner-city hospital. PATIENTS Six persons who received Babesia
microti–infected blood components from a donor. MAIN OUTCOME MEASURE Diagnosis and successful therapy of
babesiosis following transfusion. RESULTS Six individuals (1 adult, 1 child, and 4 neonates) were
exposed to products from a single blood donation by an asymptomatic
Babesia-infected donor. Three of the 6 exposed patients became
parasitemic. Polymerase chain reaction testing, animal inoculation
studies, and indirect immunofluorescent antibody testing were used to
confirm the presence of Babesia microti in the donor's blood
and to establish the presence of infection in 3 of the 6 recipients.
The 3 infected recipients and 1 additional recipient were treated
without incident. CONCLUSION Physicians should consider babesiosis in the
differential diagnosis of a febrile hemolytic disorder after blood
transfusion. Prompt diagnosis is important since babesiosis is
responsive to antibiotic therapy and, untreated, can be a fatal disease
in certain risk groups.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Babesia - isolation & purification</subject><subject>Babesia microti</subject><subject>Babesiosis - diagnosis</subject><subject>Babesiosis - epidemiology</subject><subject>Babesiosis - transmission</subject><subject>Biological and medical sciences</subject><subject>Blood Donors</subject><subject>Blood transfusions</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Child</subject><subject>Cluster Analysis</subject><subject>Contact Tracing</subject><subject>Disease</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Parasitemia - diagnosis</subject><subject>Parasitemia - transmission</subject><subject>Transfusion Reaction</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0098-7484</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Utr3DAQAGARWrKbtOeSSxGh5OatRrL1OG62SRoI5ND00ovRy8GLbW099mH_fRSyZaGX6CJm9M3AjAj5AmwFjMH3re3timvI0cpwdUKWUAldiMroD2TJmNGFKnW5IGeIW5YPCHVKFrlW6dKwJfmzpptuximONDX0abQDNjO2aSjWiMm3doqBXlsXcw5bpBuLEV-dz_kpUUt_tcNzF-ka9_1uSr2dWk9_pCGNn8jHxnYYPx_uc_L79uZp87N4eLy736wfCluacip4BVY2AoLxzikGpZROgJQKolJO8aZh1mjlmA9OSTAhBll6qYNmIXIXxDm5euu7G9PfOeJU9y362HV2iGnGWhrJK6H0uxAUF4qxV3j5H9ymeRzyEDUHEMJwaTL6ekCz62Ood2Pb23Ff_9ttBt8OwKK3XZN361s8OgUcKp7ZxRvLX3l81LkBEy9t1I9Z</recordid><startdate>19990310</startdate><enddate>19990310</enddate><creator>Dobroszycki, Joanna</creator><creator>Herwaldt, Barbara L</creator><creator>Boctor, Fouad</creator><creator>Miller, James R</creator><creator>Linden, Jeanne</creator><creator>Eberhard, Mark L</creator><creator>Yoon, Jing Ja</creator><creator>Ali, Nahed M</creator><creator>Tanowitz, Herbert B</creator><creator>Graham, Fitzroy</creator><creator>Weiss, Louis M</creator><creator>Wittner, Murray</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19990310</creationdate><title>A Cluster of Transfusion-Associated Babesiosis Cases Traced to a Single Asymptomatic Donor</title><author>Dobroszycki, Joanna ; Herwaldt, Barbara L ; Boctor, Fouad ; Miller, James R ; Linden, Jeanne ; Eberhard, Mark L ; Yoon, Jing Ja ; Ali, Nahed M ; Tanowitz, Herbert B ; Graham, Fitzroy ; Weiss, Louis M ; Wittner, Murray</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a494t-251a6f31d9cbb701466b316671e77b72ff0a987b0cdb7619ded64c68d80de2bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Babesia - isolation & purification</topic><topic>Babesia microti</topic><topic>Babesiosis - diagnosis</topic><topic>Babesiosis - epidemiology</topic><topic>Babesiosis - transmission</topic><topic>Biological and medical sciences</topic><topic>Blood Donors</topic><topic>Blood transfusions</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Child</topic><topic>Cluster Analysis</topic><topic>Contact Tracing</topic><topic>Disease</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Parasitemia - diagnosis</topic><topic>Parasitemia - transmission</topic><topic>Transfusion Reaction</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dobroszycki, Joanna</creatorcontrib><creatorcontrib>Herwaldt, Barbara L</creatorcontrib><creatorcontrib>Boctor, Fouad</creatorcontrib><creatorcontrib>Miller, James R</creatorcontrib><creatorcontrib>Linden, Jeanne</creatorcontrib><creatorcontrib>Eberhard, Mark L</creatorcontrib><creatorcontrib>Yoon, Jing Ja</creatorcontrib><creatorcontrib>Ali, Nahed M</creatorcontrib><creatorcontrib>Tanowitz, Herbert B</creatorcontrib><creatorcontrib>Graham, Fitzroy</creatorcontrib><creatorcontrib>Weiss, Louis M</creatorcontrib><creatorcontrib>Wittner, Murray</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>JAMA : the journal of the American Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dobroszycki, Joanna</au><au>Herwaldt, Barbara L</au><au>Boctor, Fouad</au><au>Miller, James R</au><au>Linden, Jeanne</au><au>Eberhard, Mark L</au><au>Yoon, Jing Ja</au><au>Ali, Nahed M</au><au>Tanowitz, Herbert B</au><au>Graham, Fitzroy</au><au>Weiss, Louis M</au><au>Wittner, Murray</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Cluster of Transfusion-Associated Babesiosis Cases Traced to a Single Asymptomatic Donor</atitle><jtitle>JAMA : the journal of the American Medical Association</jtitle><addtitle>JAMA</addtitle><date>1999-03-10</date><risdate>1999</risdate><volume>281</volume><issue>10</issue><spage>927</spage><epage>930</epage><pages>927-930</pages><issn>0098-7484</issn><eissn>1538-3598</eissn><coden>JAMAAP</coden><abstract>CONTEXT The risk of acquiring babesiosis by blood transfusion
is largely unknown since in areas where it is endemic it is often an
asymptomatic infection. OBJECTIVE To investigate and treat a cluster of blood
transfusion–associated babesiosis cases. DESIGN Case series and epidemiologic investigation. SETTING Urban inner-city hospital. PATIENTS Six persons who received Babesia
microti–infected blood components from a donor. MAIN OUTCOME MEASURE Diagnosis and successful therapy of
babesiosis following transfusion. RESULTS Six individuals (1 adult, 1 child, and 4 neonates) were
exposed to products from a single blood donation by an asymptomatic
Babesia-infected donor. Three of the 6 exposed patients became
parasitemic. Polymerase chain reaction testing, animal inoculation
studies, and indirect immunofluorescent antibody testing were used to
confirm the presence of Babesia microti in the donor's blood
and to establish the presence of infection in 3 of the 6 recipients.
The 3 infected recipients and 1 additional recipient were treated
without incident. CONCLUSION Physicians should consider babesiosis in the
differential diagnosis of a febrile hemolytic disorder after blood
transfusion. Prompt diagnosis is important since babesiosis is
responsive to antibiotic therapy and, untreated, can be a fatal disease
in certain risk groups.</abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>10078490</pmid><doi>10.1001/jama.281.10.927</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | JAMA : the journal of the American Medical Association, 1999-03, Vol.281 (10), p.927-930 |
| issn | 0098-7484 1538-3598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69625378 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Babesia - isolation & purification Babesia microti Babesiosis - diagnosis Babesiosis - epidemiology Babesiosis - transmission Biological and medical sciences Blood Donors Blood transfusions Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Child Cluster Analysis Contact Tracing Disease Humans Infant, Newborn Medical sciences Parasitemia - diagnosis Parasitemia - transmission Transfusion Reaction Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | A Cluster of Transfusion-Associated Babesiosis Cases Traced to a Single Asymptomatic Donor |
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