Role of the Phosphoinositide 3-Kinase-Akt-Mammalian Target of the Rapamycin Signaling Pathway in Long-Term Potentiation and Trace Fear Conditioning Memory in Rat Medial Prefrontal Cortex

Phosphatidylinositol 3-kinase (PI3K) and its downstream targets, including Akt (also known as protein kinase B, PKB), mammalian target of rapamycin (mTOR), the 70-kDa ribosomal S6 kinase (p70S6k), and the eukaryotic initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1), may play important roles in...

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Veröffentlicht in:	Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2008-10, Vol.15 (10), p.762-776
Hauptverfasser:	Sui, Li, Wang, Jing, Li, Bao-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavioral psychophysiology Biochemistry Biological and medical sciences Blotting, Western Brain Hemisphere Functions Conditioning Conditioning, Classical - physiology Drug Use Electrophysiology Enzyme Inhibitors - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fear Fear - drug effects Fear - physiology Fundamental and applied biological sciences. Psychology Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Memory Memory - drug effects Memory - physiology Phosphatidylinositol 3-Kinases - drug effects Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Protein Kinases - drug effects Protein Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Recognition (Psychology) Signal Transduction - drug effects Signal Transduction - physiology Stimulation Synaptic Transmission - drug effects Synaptic Transmission - physiology TOR Serine-Threonine Kinases
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