Bovine Milk Glycome
Bovine milk oligosaccharides have several potentially important biological activities including the prevention of pathogen binding to the intestinal epithelial and as nutrients for beneficial bacteria. It has been suggested that milk oligosaccharides are an important source of complex carbohydrates...
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| Veröffentlicht in: | Journal of dairy science 2008-10, Vol.91 (10), p.3768-3778 |
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| creator | Tao, N. DePeters, E.J. Freeman, S. German, J.B. Grimm, R. Lebrilla, C.B. |
| description | Bovine milk oligosaccharides have several potentially important biological activities including the prevention of pathogen binding to the intestinal epithelial and as nutrients for beneficial bacteria. It has been suggested that milk oligosaccharides are an important source of complex carbohydrates as supplements for the food and the pharmaceutical industries. However, only a small number of structures of bovine milk oligosaccharides (bMO) are known. There have been no systematic studies on bMO. High-performance mass spectrometry and separation methods are used to evaluate bMO, and nearly 40 oligosaccharides are present in bovine milk. Bovine milk oligosaccharides are composed of shorter oligomeric chains than are those in human milk. They are significantly more anionic with nearly 70%, measured abundances, being sialylated. Additionally, bMO are built not only on the lactose core (as are nearly all human milk oligosaccharides), but also on lactose amines. Sialic acid residues include both N-acetyl and N-glycolylneuraminic acid, although the former is significantly more abundant. |
| doi_str_mv | 10.3168/jds.2008-1305 |
| format | Article |
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It has been suggested that milk oligosaccharides are an important source of complex carbohydrates as supplements for the food and the pharmaceutical industries. However, only a small number of structures of bovine milk oligosaccharides (bMO) are known. There have been no systematic studies on bMO. High-performance mass spectrometry and separation methods are used to evaluate bMO, and nearly 40 oligosaccharides are present in bovine milk. Bovine milk oligosaccharides are composed of shorter oligomeric chains than are those in human milk. They are significantly more anionic with nearly 70%, measured abundances, being sialylated. Additionally, bMO are built not only on the lactose core (as are nearly all human milk oligosaccharides), but also on lactose amines. Sialic acid residues include both N-acetyl and N-glycolylneuraminic acid, although the former is significantly more abundant.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.2008-1305</identifier><identifier>PMID: 18832198</identifier><identifier>CODEN: JDSCAE</identifier><language>eng</language><publisher>Savoy, IL: Elsevier Inc</publisher><subject>amines ; Animal productions ; Animals ; bioactive properties ; Biological and medical sciences ; bovine milk ; Cattle - physiology ; Chromatography, Liquid ; Female ; Food industries ; Fundamental and applied biological sciences. Psychology ; Glycomics ; high-performance liquid chromatography ; intestinal microorganisms ; lactose ; mass spectrometry ; milk ; Milk - chemistry ; milk analysis ; Milk and cheese industries. Ice creams ; milk composition ; oligosaccharide ; oligosaccharides ; Oligosaccharides - chemistry ; sialic acids ; Spectroscopy, Fourier Transform Infrared ; Terrestrial animal productions ; Vertebrates</subject><ispartof>Journal of dairy science, 2008-10, Vol.91 (10), p.3768-3778</ispartof><rights>2008 American Dairy Science Association</rights><rights>2008 INIST-CNRS</rights><rights>Copyright American Dairy Science Association Oct 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-bacd93661295e129f049f8b438e515c2986ca3985d6855ae306bb32df12b90eb3</citedby><cites>FETCH-LOGICAL-c491t-bacd93661295e129f049f8b438e515c2986ca3985d6855ae306bb32df12b90eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3168/jds.2008-1305$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20715130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18832198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tao, N.</creatorcontrib><creatorcontrib>DePeters, E.J.</creatorcontrib><creatorcontrib>Freeman, S.</creatorcontrib><creatorcontrib>German, J.B.</creatorcontrib><creatorcontrib>Grimm, R.</creatorcontrib><creatorcontrib>Lebrilla, C.B.</creatorcontrib><title>Bovine Milk Glycome</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>Bovine milk oligosaccharides have several potentially important biological activities including the prevention of pathogen binding to the intestinal epithelial and as nutrients for beneficial bacteria. It has been suggested that milk oligosaccharides are an important source of complex carbohydrates as supplements for the food and the pharmaceutical industries. However, only a small number of structures of bovine milk oligosaccharides (bMO) are known. There have been no systematic studies on bMO. High-performance mass spectrometry and separation methods are used to evaluate bMO, and nearly 40 oligosaccharides are present in bovine milk. Bovine milk oligosaccharides are composed of shorter oligomeric chains than are those in human milk. They are significantly more anionic with nearly 70%, measured abundances, being sialylated. Additionally, bMO are built not only on the lactose core (as are nearly all human milk oligosaccharides), but also on lactose amines. Sialic acid residues include both N-acetyl and N-glycolylneuraminic acid, although the former is significantly more abundant.</description><subject>amines</subject><subject>Animal productions</subject><subject>Animals</subject><subject>bioactive properties</subject><subject>Biological and medical sciences</subject><subject>bovine milk</subject><subject>Cattle - physiology</subject><subject>Chromatography, Liquid</subject><subject>Female</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycomics</subject><subject>high-performance liquid chromatography</subject><subject>intestinal microorganisms</subject><subject>lactose</subject><subject>mass spectrometry</subject><subject>milk</subject><subject>Milk - chemistry</subject><subject>milk analysis</subject><subject>Milk and cheese industries. Ice creams</subject><subject>milk composition</subject><subject>oligosaccharide</subject><subject>oligosaccharides</subject><subject>Oligosaccharides - chemistry</subject><subject>sialic acids</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Terrestrial animal productions</subject><subject>Vertebrates</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LJDEQQMOirOPsnhavKoLuqTWVdNLJUcUvmGUP6jmk09WasT80mVH896btQUHwkhB4vFQ9QraAHnKQ6mhexUNGqcqAU_GDTEAwkXHQao1MKGUso5yyDbIZ4zw9gVHxk2yAUpwlZkL-nPTPvsPdf7552L1oXl3f4i-yXtsm4u_VPSW352c3p5fZ7P_F1enxLHO5hkVWWldpLiUwLTAdNc11rcqcKxQgHNNKOsu1EpVUQljkVJYlZ1UNrNQUSz4lB6P3MfRPS4wL0_rosGlsh_0yGqkly3NQCdz7As77ZejSbAa0UKzIC5GgbIRc6GMMWJvH4FsbXg1QM6QyKZUZUpkhVeK3V9Jl2WL1Sa_aJGB_BdjobFMH2zkfPzhGCxDJlLi_I3fv7-5ffEATW9s0SQvDlxreByjkYNwZydr2xt6FZLu9ZjRJQORFroehipHA1P3ZYzDReewcVsnrFqbq_TfrvAEzDpZe</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Tao, N.</creator><creator>DePeters, E.J.</creator><creator>Freeman, S.</creator><creator>German, J.B.</creator><creator>Grimm, R.</creator><creator>Lebrilla, C.B.</creator><general>Elsevier Inc</general><general>American Dairy Science Association</general><general>Am Dairy Sci Assoc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Bovine Milk Glycome</title><author>Tao, N. ; DePeters, E.J. ; Freeman, S. ; German, J.B. ; Grimm, R. ; Lebrilla, C.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-bacd93661295e129f049f8b438e515c2986ca3985d6855ae306bb32df12b90eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>amines</topic><topic>Animal productions</topic><topic>Animals</topic><topic>bioactive properties</topic><topic>Biological and medical sciences</topic><topic>bovine milk</topic><topic>Cattle - physiology</topic><topic>Chromatography, Liquid</topic><topic>Female</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycomics</topic><topic>high-performance liquid chromatography</topic><topic>intestinal microorganisms</topic><topic>lactose</topic><topic>mass spectrometry</topic><topic>milk</topic><topic>Milk - chemistry</topic><topic>milk analysis</topic><topic>Milk and cheese industries. Ice creams</topic><topic>milk composition</topic><topic>oligosaccharide</topic><topic>oligosaccharides</topic><topic>Oligosaccharides - chemistry</topic><topic>sialic acids</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Terrestrial animal productions</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tao, N.</creatorcontrib><creatorcontrib>DePeters, E.J.</creatorcontrib><creatorcontrib>Freeman, S.</creatorcontrib><creatorcontrib>German, J.B.</creatorcontrib><creatorcontrib>Grimm, R.</creatorcontrib><creatorcontrib>Lebrilla, C.B.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tao, N.</au><au>DePeters, E.J.</au><au>Freeman, S.</au><au>German, J.B.</au><au>Grimm, R.</au><au>Lebrilla, C.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bovine Milk Glycome</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>91</volume><issue>10</issue><spage>3768</spage><epage>3778</epage><pages>3768-3778</pages><issn>0022-0302</issn><eissn>1525-3198</eissn><coden>JDSCAE</coden><abstract>Bovine milk oligosaccharides have several potentially important biological activities including the prevention of pathogen binding to the intestinal epithelial and as nutrients for beneficial bacteria. It has been suggested that milk oligosaccharides are an important source of complex carbohydrates as supplements for the food and the pharmaceutical industries. However, only a small number of structures of bovine milk oligosaccharides (bMO) are known. There have been no systematic studies on bMO. High-performance mass spectrometry and separation methods are used to evaluate bMO, and nearly 40 oligosaccharides are present in bovine milk. Bovine milk oligosaccharides are composed of shorter oligomeric chains than are those in human milk. They are significantly more anionic with nearly 70%, measured abundances, being sialylated. Additionally, bMO are built not only on the lactose core (as are nearly all human milk oligosaccharides), but also on lactose amines. Sialic acid residues include both N-acetyl and N-glycolylneuraminic acid, although the former is significantly more abundant.</abstract><cop>Savoy, IL</cop><pub>Elsevier Inc</pub><pmid>18832198</pmid><doi>10.3168/jds.2008-1305</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | amines Animal productions Animals bioactive properties Biological and medical sciences bovine milk Cattle - physiology Chromatography, Liquid Female Food industries Fundamental and applied biological sciences. Psychology Glycomics high-performance liquid chromatography intestinal microorganisms lactose mass spectrometry milk Milk - chemistry milk analysis Milk and cheese industries. Ice creams milk composition oligosaccharide oligosaccharides Oligosaccharides - chemistry sialic acids Spectroscopy, Fourier Transform Infrared Terrestrial animal productions Vertebrates |
| title | Bovine Milk Glycome |
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