A Single Conductance Pore for Chloride Ions Formed by Two Cystic Fibrosis Transmembrane Conductance Regulator Molecules

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent protein kinase (PKA)- and ATP-regulated chloride channel, whose gating process involves intra- or intermolecular interactions among the cytosolic domains of the CFTR protein. Tandem linkage of two CFTR molecules produ...

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Veröffentlicht in:	The Journal of biological chemistry 1999-03, Vol.274 (12), p.7627-7630
Hauptverfasser:	Zerhusen, B, Zhao, J, Xie, J, Davis, P B, Ma, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Cell Line Chloride Channels - metabolism Chlorides - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Dimerization Humans Ion Channel Gating Lipid Bilayers - metabolism Thrombin - pharmacology
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