Delivery of adenoviral vectors to the prostate for gene therapy

Prostate cancer has become the most frequently occurring cancer and the second leading cause of cancer deaths in men. One novel approach to combat prostate cancer is gene therapy. A replication-deficient recombinant adenoviral vector (AdRSVlacZ) expressing bacterial beta-galactosidase (beta-gal) (la...

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Veröffentlicht in:	Cancer gene therapy 1999-01, Vol.6 (1), p.64-72
Hauptverfasser:	Lu, Y, Carraher, J, Zhang, Y, Armstrong, J, Lerner, J, Rogers, W P, Steiner, M S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Animals beta-Galactosidase - administration & dosage beta-Galactosidase - metabolism Blotting, Southern Colorimetry Dogs Enzymatic activity Expression vectors Galactosides - metabolism Gene therapy Genetic Therapy - methods Genetic Vectors - administration & dosage Indoles - metabolism Injection Intravenous administration LacZ gene Male Polymerase chain reaction Prostate - metabolism Prostate cancer Prostatic Neoplasms - therapy Rous sarcoma virus Tissue Distribution Vectors (Biology) β-Galactosidase
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