In vivo macrophage activity imaging in the central nervous system detected by magnetic resonance
Cell‐specific imaging has been proposed to increase the potential of magnetic resonance imaging (MRI) for tissue analysis. The hypothezis of the present work was that following intravenous injection of ultra‐small particle iron oxide, a contrast agent that accumulates in mononuclear phagocyte cells,...
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| Veröffentlicht in: | Magnetic resonance in medicine 1999-02, Vol.41 (2), p.329-333 |
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| container_title | Magnetic resonance in medicine |
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| creator | Dousset, Vincent Delalande, Christophe Ballarino, Lucrecia Quesson, Bruno Seilhan, Danielle Coussemacq, Monique Thiaudiére, Eric Brochet, Bruno Canioni, Paul Caillé, Jean-Marie |
| description | Cell‐specific imaging has been proposed to increase the potential of magnetic resonance imaging (MRI) for tissue analysis. The hypothezis of the present work was that following intravenous injection of ultra‐small particle iron oxide, a contrast agent that accumulates in mononuclear phagocyte cells, macrophages with iron burden would be detectable by MRI within the central nervous system at sites of inflammatory cellular activity. In experimental autoimmune encephalomyelitis in Lewis rats (in which intense macrophage activity results from both hematogenous macrophages and activated microglia), lesions have been seen by MRI as low signal intensities related to magnetic susceptibility effects induced by iron particles. Electron microscopy has revealed the presence of such particles within the cytoplasm of cells that had the morphological aspect of macrophages. Macrophage activity imaging might increase MRI capability with regard to the in vivo pathophysiological aspects of central nervous system (CNS) diseases and might help in therapeutic trials in the numerous CNS diseases in which macrophages are involved. Magn Reson Med 41:329–333, 1999. © 1999 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1522-2594(199902)41:2<329::AID-MRM17>3.0.CO;2-Z |
| format | Article |
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The hypothezis of the present work was that following intravenous injection of ultra‐small particle iron oxide, a contrast agent that accumulates in mononuclear phagocyte cells, macrophages with iron burden would be detectable by MRI within the central nervous system at sites of inflammatory cellular activity. In experimental autoimmune encephalomyelitis in Lewis rats (in which intense macrophage activity results from both hematogenous macrophages and activated microglia), lesions have been seen by MRI as low signal intensities related to magnetic susceptibility effects induced by iron particles. Electron microscopy has revealed the presence of such particles within the cytoplasm of cells that had the morphological aspect of macrophages. Macrophage activity imaging might increase MRI capability with regard to the in vivo pathophysiological aspects of central nervous system (CNS) diseases and might help in therapeutic trials in the numerous CNS diseases in which macrophages are involved. Magn Reson Med 41:329–333, 1999. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/(SICI)1522-2594(199902)41:2<329::AID-MRM17>3.0.CO;2-Z</identifier><identifier>PMID: 10080281</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>allergic ; Animals ; Biological and medical sciences ; Brain - pathology ; contrast agents ; Contrast Media - administration & dosage ; Dextrans ; encephalomyelitis ; Encephalomyelitis, Autoimmune, Experimental - pathology ; Female ; Ferrosoferric Oxide ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Iron ; macrophages ; Macrophages - pathology ; Magnetic Resonance Imaging ; magnetic resonance imaging (MRI) ; Magnetite Nanoparticles ; Medical sciences ; Nervous system ; Oxides ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rats ; Rats, Inbred Lew ; Spinal Cord - pathology</subject><ispartof>Magnetic resonance in medicine, 1999-02, Vol.41 (2), p.329-333</ispartof><rights>Copyright © 1999 Wiley‐Liss, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4977-3690ff9bb0e6ced73e9e25a85c7ef0bfbab93cbcd34d025602e9e7df7f3f2da13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291522-2594%28199902%2941%3A2%3C329%3A%3AAID-MRM17%3E3.0.CO%3B2-Z$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291522-2594%28199902%2941%3A2%3C329%3A%3AAID-MRM17%3E3.0.CO%3B2-Z$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1705246$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10080281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dousset, Vincent</creatorcontrib><creatorcontrib>Delalande, Christophe</creatorcontrib><creatorcontrib>Ballarino, Lucrecia</creatorcontrib><creatorcontrib>Quesson, Bruno</creatorcontrib><creatorcontrib>Seilhan, Danielle</creatorcontrib><creatorcontrib>Coussemacq, Monique</creatorcontrib><creatorcontrib>Thiaudiére, Eric</creatorcontrib><creatorcontrib>Brochet, Bruno</creatorcontrib><creatorcontrib>Canioni, Paul</creatorcontrib><creatorcontrib>Caillé, Jean-Marie</creatorcontrib><title>In vivo macrophage activity imaging in the central nervous system detected by magnetic resonance</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>Cell‐specific imaging has been proposed to increase the potential of magnetic resonance imaging (MRI) for tissue analysis. The hypothezis of the present work was that following intravenous injection of ultra‐small particle iron oxide, a contrast agent that accumulates in mononuclear phagocyte cells, macrophages with iron burden would be detectable by MRI within the central nervous system at sites of inflammatory cellular activity. In experimental autoimmune encephalomyelitis in Lewis rats (in which intense macrophage activity results from both hematogenous macrophages and activated microglia), lesions have been seen by MRI as low signal intensities related to magnetic susceptibility effects induced by iron particles. Electron microscopy has revealed the presence of such particles within the cytoplasm of cells that had the morphological aspect of macrophages. Macrophage activity imaging might increase MRI capability with regard to the in vivo pathophysiological aspects of central nervous system (CNS) diseases and might help in therapeutic trials in the numerous CNS diseases in which macrophages are involved. Magn Reson Med 41:329–333, 1999. © 1999 Wiley‐Liss, Inc.</description><subject>allergic</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>contrast agents</subject><subject>Contrast Media - administration & dosage</subject><subject>Dextrans</subject><subject>encephalomyelitis</subject><subject>Encephalomyelitis, Autoimmune, Experimental - pathology</subject><subject>Female</subject><subject>Ferrosoferric Oxide</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iron</subject><subject>macrophages</subject><subject>Macrophages - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>magnetic resonance imaging (MRI)</subject><subject>Magnetite Nanoparticles</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Oxides</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Spinal Cord - pathology</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1v0zAUhiMEYt3gLyBfILRdpPgjievyIU0FRqR21RgMqTcHxznpDEnaxWkh_x6XVAUJJK4sHb1-_J7HQfCK0SGjlD8_vU4n6RmLOQ95rKJTppSi_CxiY_5ScDUen6dvwtmHGZOvxZAOJ_MXPFzcCwaHG_eDAZURDQVT0VFw7NxXSqlSMnoYHPkXRpSP2CD4ktZka7crUmnTrNa3eolEm9ZubdsRW-mlrZfE1qS9RWKwbhtdkhqb7WrjiOtcixXJsUXTYk6yzlOWNbbWkAbdqta1wUfBg0KXDh_vz5Pg07u3Hyfvw-n8Ip2cT0MTKSlDkShaFCrLKCYGcylQIY_1KDYSC5oVmc6UMJnJRZRTHieU-4DMC1mIgueaiZPgWc9dN6u7DboWKusMlqWu0ZeFRCVcjOKROBTw-zrXYAHrxi_adMAo7NQD7NTDTiTsREKvHiIGHLx6AK8efqkHARQmcz9feO6TfYFNVmH-B7V37QNP9wHtjC6Lxuux7ndO0phHiY_d9LHvtsTur3L_6favav3Ag8MebP23_TiAdfMNEilkDJ8vL2B2dXV9czldgBI_AfK3vWg</recordid><startdate>199902</startdate><enddate>199902</enddate><creator>Dousset, Vincent</creator><creator>Delalande, Christophe</creator><creator>Ballarino, Lucrecia</creator><creator>Quesson, Bruno</creator><creator>Seilhan, Danielle</creator><creator>Coussemacq, Monique</creator><creator>Thiaudiére, Eric</creator><creator>Brochet, Bruno</creator><creator>Canioni, Paul</creator><creator>Caillé, Jean-Marie</creator><general>John Wiley & Sons, Inc</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199902</creationdate><title>In vivo macrophage activity imaging in the central nervous system detected by magnetic resonance</title><author>Dousset, Vincent ; Delalande, Christophe ; Ballarino, Lucrecia ; Quesson, Bruno ; Seilhan, Danielle ; Coussemacq, Monique ; Thiaudiére, Eric ; Brochet, Bruno ; Canioni, Paul ; Caillé, Jean-Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4977-3690ff9bb0e6ced73e9e25a85c7ef0bfbab93cbcd34d025602e9e7df7f3f2da13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>allergic</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>contrast agents</topic><topic>Contrast Media - administration & dosage</topic><topic>Dextrans</topic><topic>encephalomyelitis</topic><topic>Encephalomyelitis, Autoimmune, Experimental - pathology</topic><topic>Female</topic><topic>Ferrosoferric Oxide</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iron</topic><topic>macrophages</topic><topic>Macrophages - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>magnetic resonance imaging (MRI)</topic><topic>Magnetite Nanoparticles</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Oxides</topic><topic>Radiodiagnosis. 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Reson. Med</addtitle><date>1999-02</date><risdate>1999</risdate><volume>41</volume><issue>2</issue><spage>329</spage><epage>333</epage><pages>329-333</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>Cell‐specific imaging has been proposed to increase the potential of magnetic resonance imaging (MRI) for tissue analysis. The hypothezis of the present work was that following intravenous injection of ultra‐small particle iron oxide, a contrast agent that accumulates in mononuclear phagocyte cells, macrophages with iron burden would be detectable by MRI within the central nervous system at sites of inflammatory cellular activity. In experimental autoimmune encephalomyelitis in Lewis rats (in which intense macrophage activity results from both hematogenous macrophages and activated microglia), lesions have been seen by MRI as low signal intensities related to magnetic susceptibility effects induced by iron particles. Electron microscopy has revealed the presence of such particles within the cytoplasm of cells that had the morphological aspect of macrophages. Macrophage activity imaging might increase MRI capability with regard to the in vivo pathophysiological aspects of central nervous system (CNS) diseases and might help in therapeutic trials in the numerous CNS diseases in which macrophages are involved. Magn Reson Med 41:329–333, 1999. © 1999 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10080281</pmid><doi>10.1002/(SICI)1522-2594(199902)41:2<329::AID-MRM17>3.0.CO;2-Z</doi><tpages>5</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 1999-02, Vol.41 (2), p.329-333 |
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| source | MEDLINE; Wiley Free Content; Wiley Online Library All Journals |
| subjects | allergic Animals Biological and medical sciences Brain - pathology contrast agents Contrast Media - administration & dosage Dextrans encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - pathology Female Ferrosoferric Oxide Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Iron macrophages Macrophages - pathology Magnetic Resonance Imaging magnetic resonance imaging (MRI) Magnetite Nanoparticles Medical sciences Nervous system Oxides Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Inbred Lew Spinal Cord - pathology |
| title | In vivo macrophage activity imaging in the central nervous system detected by magnetic resonance |
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