Gene Signature of Stromal Cells which Support Dendritic Cell Development

Spleen stromal cells are critical determinants of dendritic cell (DC) development in spleen. The spleen stromal line, namely STX3, supports DC differentiation in vitro from overlaid bone marrow cells while the lymph node stromal line, namely 2RL22, does not. Here we have characterised the hematopoie...

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Veröffentlicht in:	Stem cells and development 2008-10, Vol.17 (5), p.917-928
Hauptverfasser:	Despars, Geneviève, Periasamy, Pravin, Tan, Jonathan, Abbey, Janice, O'Neill, Terence J., O'Neill, Helen C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Bone Marrow Cells - cytology Cell Differentiation Cell Line Cell Lineage Coculture Techniques Dendritic cells Dendritic Cells - cytology Dendritic Cells - metabolism Endothelial Cells - cytology Endothelial Cells - metabolism Fibroblasts - metabolism Gene Expression Profiling Genetic aspects Hematopoiesis Integrins - genetics Integrins - metabolism Mice Mice, Inbred C57BL Myeloid Cells - cytology ORIGINAL RESEARCH REPORTS Physiological aspects Properties Spleen - cytology Stem cells Stromal Cells - metabolism
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