The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin

Replication licensing factor (RLF) is an essential initiation factor that can prevent re-replication of DNA in a single cell cycle [1,2]. It is required for the initiation of DNA replication, binds to chromatin early in the cell cycle, is removed from chromatin as DNA replicates and is unable to re-...

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Veröffentlicht in:	Current biology 1999-02, Vol.9 (4), p.211-215
Hauptverfasser:	Tada, Shusuke, Chong, James P.J., Mahbubani, Hiro M., Blow, J.Julian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Cell Cycle Proteins - isolation & purification Cell Cycle Proteins - metabolism Cell Nucleus - physiology Chromatin - metabolism Chromosomal Proteins, Non-Histone - metabolism DNA Replication Female Male Ovum - physiology Saccharomyces cerevisiae Proteins Spermatozoa - physiology Transcription Factors - chemistry Transcription Factors - isolation & purification Transcription Factors - metabolism Xenopus Xenopus Proteins Zinc Fingers
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