Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12

Direct intratumoral (i.t.) injection of adenoviruses (Ads) expressing specific immunostimulatory cytokines represents an attractive strategy for the clinical implementation of cytokine gene therapy of cancer. Interleukin-12 (IL-12) is a heterodimeric cytokine produced by antigen-presenting cells and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer gene therapy 1999-01, Vol.6 (1), p.45-53
Hauptverfasser:	Gambotto, A, Tüting, T, McVey, D L, Kovesdi, I, Tahara, H, Lotze, M T, Robbins, P D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - therapy Adenoviridae - genetics Adenovirus Adenoviruses AIDS/HIV Animals Antigen-presenting cells Biological activity CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cytokines Cytomegalovirus Cytotoxicity Enzyme-Linked Immunosorbent Assay Female Fibrosarcoma - immunology Fibrosarcoma - therapy Gene therapy Genetic Vectors Immunity Immunostimulation Immunotherapy Injection Injections, Intralesional Interferon-gamma - blood Interferon-gamma - pharmacology Interleukin 12 Interleukin-12 - genetics Interleukin-12 - pharmacology Interleukin-12 - therapeutic use Lymphocytes T Mice Mice, Inbred C57BL Recombinant Proteins - pharmacology Serum levels Spleen Splenocytes T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Time Factors Transcription Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!