Renin inhibition by substituted piperidines: A novel paradigm for the inhibition of monomeric aspartic proteinases?

The aspartic proteinase renin catalyses the first and rate-limiting step in the conversion of angiotensinogen to the hormone angiotensin II, and therefore plays an important physiological role in the regulation of blood pressure. Numerous potent peptidomimetic inhibitors of this important drug targe...

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Veröffentlicht in:	Chemistry & biology 1999-03, Vol.6 (3), p.127-131
Hauptverfasser:	Oefner, C, Binggeli, A, Breu, V, Bur, D, Clozel, J-P, D'Arcy, A, Dorn, A, Fischli, W, Grüninger, F, Güller, R, Hirth, G, Märki, HP, Mathews, S, Müller, M, Ridley, RG, Stadier, H, Vieira, E, Wilhelm, M, Winkler, FK, Wostl, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic Acid Endopeptidases - antagonists & inhibitors aspartic proteinase drug design Fluorescein Gene Library Glutathione - metabolism Histidine - metabolism Humans induced fit Piperidines - pharmacology Protein Biosynthesis Proteins - genetics ras Proteins - metabolism renin Renin - antagonists & inhibitors X-ray analysis
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