Regioselective De Novo Synthesis of Cyanohydroxypyridines with a Concerted Cycloaddition Mechanism

An efficient cycloaddition reaction of 1-alkoxy-1-azadienes with α,α-dicyanoalkenes is described, which gives facile access to highly substituted 3-hydroxypyridines in very good yields and with complete regiocontrol and chemoselectivity. The reaction path was investigated in detail by quantum mechan...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-10, Vol.130 (40), p.13219-13221
Hauptverfasser:	Lu, Jin-Yong, Keith, John A, Shen, Wei-Zheng, Schürmann, Markus, Preut, Hans, Jacob, Timo, Arndt, Hans-Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Aza Compounds - chemistry Cyanides - chemistry Cyclization Models, Molecular Molecular Structure Pyridines - chemical synthesis Pyridines - chemistry
Online-Zugang:	Volltext
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