Substrate Specificity and Stereoselectivity of Rat Brain Microsomal Anandamide Amidohydrolase

Anandamide amidohydrolase (AAH) catalyzes the hydrolysis of arachidonylethanolamide (anandamide), an endogenous cannabinoid receptor ligand. To delineate the structural requirements of AAH substrates, rat brain microsomal AAH hydrolysis of a series of anandamide congeners was studied using two rever...

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Veröffentlicht in:	Journal of medicinal chemistry 1999-03, Vol.42 (5), p.896-902
Hauptverfasser:	Lang, Wensheng, Qin, Ce, Lin, Sonyuan, Khanolkar, Atmaram D, Goutopoulos, Andreas, Fan, Pusheng, Abouzid, Khaled, Meng, Zhaoxing, Biegel, Diane, Makriyannis, Alexandros
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Animals Arachidonic Acids - metabolism Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain - enzymology Brain - ultrastructure Cannabinoids - chemistry Cannabinoids - metabolism Endocannabinoids Hydrolysis Kinetics Ligands Medical sciences Microsomes - enzymology Pharmacology. Drug treatments Polyunsaturated Alkamides Rats Receptors, Cannabinoid Receptors, Drug - agonists Receptors, Drug - metabolism Stereoisomerism Substrate Specificity
Online-Zugang:	Volltext
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