A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

Epithelial to mesenchymal transition occurs during embryologic development to allow tissue remodeling and is proposed to be a key step in the metastasis of epithelial-derived tumors. The miR-200 family of microRNAs plays a major role in specifying the epithelial phenotype by preventing expression of...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-10, Vol.68 (19), p.7846-7854
Hauptverfasser:	BRACKEN, Cameron P, GREGORY, Philip A, KOLESNIKOFF, Natasha, BERT, Andrew G, JUN WANG, SHANNON, M. Frances, GOODALL, Gregory J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cells, Cultured Dogs E-Box Elements - physiology Epithelial Cells - physiology Feedback, Physiological - genetics Feedback, Physiological - physiology Gene Expression Regulation Homeodomain Proteins - physiology Humans Medical sciences Mesoderm - physiology Mice MicroRNAs - genetics MicroRNAs - physiology Models, Biological Multigene Family - physiology Nerve Tissue Proteins - physiology Pharmacology. Drug treatments Promoter Regions, Genetic RNA, Messenger - metabolism RNA-Binding Proteins - physiology Transcription Factors - physiology Tumors Zinc Finger E-box-Binding Homeobox 1
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