Neuroprotective Effects of Caspase-3 Inhibition on Functional Recovery and Tissue Sparing After Acute Spinal Cord Injury

We used gene microarrays and found that caspase-related death genes were upregulated. We tested caspase inhibition and evaluated its effect on the spinal cord after traumatic injury. The logical extension of previous studies was to determine whether downstream CASP genes might also be involved and w...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2008-10, Vol.33 (21), p.2269-2277
Hauptverfasser:	CITRON, Bruce A, ARNOLD, Paul M, HAYNES, Neal G, AMEENUDDIN, Syed, FAROOQUE, Mohammed, SANTACRUZ, Karen, FESTOFF, Barry W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Biological and medical sciences Caspase 3 - metabolism Caspase Inhibitors Cerebrospinal fluid. Meninges. Spinal cord Enzyme Activation - drug effects Female Injuries of the nervous system and the skull. Diseases due to physical agents Medical sciences Motor Neurons - drug effects Motor Neurons - enzymology Motor Neurons - pathology Nervous system (semeiology, syndromes) Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Rats Rats, Sprague-Dawley Recovery of Function - drug effects Recovery of Function - physiology Spinal Cord Injuries - drug therapy Spinal Cord Injuries - enzymology Spinal Cord Injuries - pathology Traumas. Diseases due to physical agents
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