Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling

We had previously shown that both locally produced endocannabinoids and exocannabinoids, via cannabinoid receptor-1 (CB1), are powerful inhibitors of human hair growth. To further investigate the role of the cannabinoid system in pilosebaceous unit biology, we have explored in the current study whet...

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Veröffentlicht in:	The FASEB journal 2008-10, Vol.22 (10), p.3685-3695
Hauptverfasser:	Dobrosi, Nóra, Tóth, Balázs I, Nagy, Georgina, Dózsa, Anikó, Géczy, Tamás, Nagy, László, Zouboulis, Christos C, Paus, Ralf, Kovács, László, Bíró, Tamás
Format:	Artikel
Sprache:	eng
Schlagworte:	acne vulgaris Apoptosis Cannabinoid Receptor Modulators - metabolism cannabinoid receptor subtypes Cell Line Endocannabinoids Epithelium - metabolism gene expression Gene Expression Regulation human sebaceous gland‐derived SZ95 sebocytes Humans Lipogenesis - genetics Mitogen-Activated Protein Kinases - metabolism peroxisome proliferator‐activated receptor Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - genetics Receptor, Cannabinoid, CB2 - metabolism RNA Interference Sebaceous Glands - cytology Sebaceous Glands - metabolism Signal Transduction
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