In Vitro and in Vivo Vasodilatory Activity of barnidipine and Its Enantiomers

Barnidipine, (3'S)-1-benzyl-3-pyrrolidinyl methyl (4S)-2, 6-dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate, is a dihydropyridine calcium antagonist with asymmetric carbons at the dihydropyridine C-4 and the pyrrolidine C-3' positions. In this study, the vasodilatory act...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1999/02/15, Vol.22(2), pp.151-156
Hauptverfasser:	INAGAKI, Osamu, ASANO, Masaharu, TAKENAKA, Toichi
Format:	Artikel
Sprache:	eng
Schlagworte:	1, 4-dihydropyridine Animals Antihypertensive agents Aorta - drug effects Aorta - physiology Atrial Function barnidipine Biological and medical sciences Cardiovascular system Dogs enantiomer Female Guinea Pigs Heart Atria - drug effects In Vitro Techniques Male Medical sciences Muscle Contraction - drug effects Nifedipine - analogs & derivatives Nifedipine - chemistry Nifedipine - pharmacology Pharmacology. Drug treatments Regional Blood Flow - drug effects Stereoisomerism stereoselectivity Vasodilator Agents - chemistry Vasodilator Agents - pharmacology
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