Immune-mediated dormancy: an equilibrium with cancer
This brief review discusses the role of the immune system in tumor development, covering a history of cancer immunity and a summary of the concept of cancer immunoediting, including its three phases: elimination, equilibrium, and escape. The latter half of this review then focuses specifically on th...
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| Veröffentlicht in: | Journal of leukocyte biology 2008-10, Vol.84 (4), p.988-993 |
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| container_issue | 4 |
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| container_title | Journal of leukocyte biology |
| container_volume | 84 |
| creator | Teng, Michele W. L. Swann, Jeremy B. Koebel, Catherine M. Schreiber, Robert D. Smyth, Mark J. |
| description | This brief review discusses the role of the immune system in tumor development, covering a history of cancer immunity and a summary of the concept of cancer immunoediting, including its three phases: elimination, equilibrium, and escape. The latter half of this review then focuses specifically on the equilibrium phase, making note of previous work, suggesting that immunity might maintain cancer in a dormant state, and concluding with a description of a tractable mouse model unequivocally demonstrating that immunity can indeed hold preformed cancer in check. These findings form a framework for future studies aimed at validating immune‐mediated cancer dormancy in humans with the hopes of devising new, immunotherapeutic strategies to treat established cancer. |
| doi_str_mv | 10.1189/jlb.1107774 |
| format | Article |
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These findings form a framework for future studies aimed at validating immune‐mediated cancer dormancy in humans with the hopes of devising new, immunotherapeutic strategies to treat established cancer.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>elimination</subject><subject>escape</subject><subject>Humans</subject><subject>Immune System</subject><subject>immunoediting</subject><subject>Interferon-gamma - immunology</subject><subject>Interleukin-12 - immunology</subject><subject>Mice</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - pathology</subject><subject>Neovascularization, Pathologic - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumor Escape - immunology</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtPwzAQhy0EoqUwsaMssKDAOXb8YIOKR1ElFpgtJ3Goqzxau1HU_x5HqcQG8nCW7rvfnT6ELjHcYSzk_brKwgc45_QITbEkIiaMk2M0BU5xnFKACTrzfg0AJGFwiiZYpDglCZ8iuqjrrjFxbQqrd6aIitbVusn3D5FuIrPtbGUzZ7s66u1uFeWhZdw5Oil15c3Foc7Q18vz5_wtXn68LuaPyzinTIiYFwInLC1YyjKArMh5KQuhISOsSAiTNLwyNbgsqSaa4SxNaV5ikWsgUoMgM3Qz5m5cu-2M36na-txUlW5M23nFJMOCJfhfMAHJOSRD4u0I5q713plSbZyttdsrDGqwqYJNdbAZ6KtDbJcFQb_sQV8AYAR6W5n9X1nqffkEUgwXXI8jK_u96q0zyte6qsKGRPV9L6iiauB-AEviimI</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Teng, Michele W. 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| identifier | ISSN: 0741-5400 |
| ispartof | Journal of leukocyte biology, 2008-10, Vol.84 (4), p.988-993 |
| issn | 0741-5400 1938-3673 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Disease Models, Animal elimination escape Humans Immune System immunoediting Interferon-gamma - immunology Interleukin-12 - immunology Mice Neoplasms - immunology Neoplasms - pathology Neovascularization, Pathologic - immunology T-Lymphocytes - immunology Tumor Escape - immunology |
| title | Immune-mediated dormancy: an equilibrium with cancer |
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